cudc-101
Small moleculeexperimental
Clinical trial activity
4 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2008 (NCT00728793)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
EGFR inhibitor
Inhibits class I (HDAC1 HDAC2 HDAC3 HDAC8) and II (HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10) HDACs
ERBB2 inhibitor
Inhibits class I (HDAC1 HDAC2 HDAC3 HDAC8) and II (HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10) HDACs
- Histone deacetylaseINHIBITOR
Histone deacetylase inhibitor
Inhibits class I (HDAC1 HDAC2 HDAC3 HDAC8) and II (HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDAC10) HDACs
- Histone deacetylase 1 (HDAC1) ↗
- Histone deacetylase 3 (HDAC3) ↗
- Histone deacetylase 6 (HDAC6) ↗
- Histone deacetylase 2 (HDAC2) ↗
- Histone deacetylase 5 (HDAC5) ↗
- Histone deacetylase 7 (HDAC7) ↗
- Histone deacetylase 8 (HDAC8) ↗
- Histone deacetylase 11 (HDAC11) ↗
- Histone deacetylase 4 (HDAC4) ↗
- Histone deacetylase 9 (HDAC9) ↗
- Histone deacetylase 10 (HDAC10) ↗
- Histone deacetylase 8
- Histone deacetylase 10
- Histone deacetylase 2
- Histone deacetylase 3
- Histone deacetylase 4
- Histone deacetylase 6
- Histone deacetylase 9
- Histone deacetylase 11
- Histone deacetylase 5
- Histone deacetylase 7
- Histone deacetylase 1
- Histone deacetylase (HDAC1 and HDAC2)
- Histone deacetylase 1/3/5/8
- Histone deacetylase 1/2/3/6
- Histone deacetylase 1/2/3
- Histone deacetylase 1/8
- Histone deacetylase 1/6
- Class 1 histone deacetylase
- Histone deacetylase 6/3
Chemistry & pharmacology
Loading structure…
SMILES
C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCC(=O)NO)cc23)c1- Mol. weight
- 434.5 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL598797 ↗
Also known as
- 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-n-hydroxyheptanamide
- cudc101
- cudc 101
- cudc-101
- cudc-101
- cudc-101
- cudc-101
- cudc-101
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01702285 | Phase 1 | Sep 1, 2012 | Curis |
| NCT01384799 | Phase 1 | Nov 1, 2011 | Curis |
| NCT01171924 | Phase 1 | Jul 1, 2010 | Curis |
| NCT00728793 | Phase 1 | Aug 1, 2008 | Curis, South Texas Accelerated Research Therapeutics |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Curis | For profit | 4 | 4 | 1 | 2008 |
| South Texas Accelerated Research Therapeutics | For profit | 1 | 0 | 1 | 2008 |
2 organizations
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