mdx447
Clinical trial activity
2 trials · 4 clinical orgs · 0 marketing orgs
Earliest trial started Mar 1, 1997 (NCT00005813)
Timeline
1990s
- Jan 1, 1997
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- High affinity immunoglobulin gamma Fc receptor ICROSS-LINKING AGENT
High affinity immunoglobulin gamma Fc receptor I cross-linking agent
Binds to the EGFR and to the high-affinity immunoglobulin G (IgG) receptor CD64 both separately and simultaneously. Mediates antibody-dependent cell-mediated cytotoxicity (ADCC) with lysis of EGFR overexpressing cell lines.
- Epidermal growth factor receptor erbB1CROSS-LINKING AGENT
Epidermal growth factor receptor erbB1 cross-linking agent
Binds to the EGFR and to the high-affinity immunoglobulin G (IgG) receptor CD64 both separately and simultaneously. Mediates antibody-dependent cell-mediated cytotoxicity (ADCC) with lysis of EGFR overexpressing cell lines.
FCGR1A inhibitor
EGFR inhibitor
FCGR1A other
Binds to the EGFR and to the high-affinity immunoglobulin G (IgG) receptor CD64 both separately and simultaneously. Mediates antibody-dependent cell-mediated cytotoxicity (ADCC) with lysis of EGFR overexpressing cell lines.
EGFR other
Binds to the EGFR and to the high-affinity immunoglobulin G (IgG) receptor CD64 both separately and simultaneously. Mediates antibody-dependent cell-mediated cytotoxicity (ADCC) with lysis of EGFR overexpressing cell lines.
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- Yes
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2109391 ↗
Also known as
- emd-82633
- mdx447
- mdx-447
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06378684 | Phase 1 | Sep 10, 2023 | JW Pharmaceutical, Yonsei University |
| NCT00005813 | Phase 1 | Mar 1, 1997 | Dartmouth University, National Cancer Institute (NCI) |
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Dartmouth University | Academic/Hospital | 1 | 1 | 1 | 1997 |
| JW Pharmaceutical | For profit | 1 | 1 | 1 | 2023 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 1997 |
| Yonsei University | Academic/Hospital | 1 | 0 | 1 | 2023 |