CDEK
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panitumumab

Trade name: vectibix

mAbapproved

Approved

Sep 27, 2006

Panitumumab, sold under the brand name Vectibix, is a fully human monoclonal antibody specific to the epidermal growth factor receptor. — Wikipedia

Clinical trial activity

240 trials · 235 clinical orgs · 1 marketing orgs

Phase 1
51
Phase 2
207
Phase 3
28
Phase 4
2

Earliest trial started Apr 1, 2000 (NCT00004879)

Timeline

2000s

  1. Jan 1, 2000

    Earliest Phase 1 Sponsor(trial)

  2. Feb 1, 2001

    Amgen — IND Organization

  3. Feb 1, 2001

    Amgen — IND Organization

  4. Jan 1, 2002

    Amgen — Earliest Phase 2 Sponsor(trial)

  5. Jan 1, 2004

    Amgen — Earliest Phase 3 Sponsor(trial)

  6. Sep 27, 2006

    Amgen — Earliest FDA Approval

  7. Sep 27, 2006

    Amgen — Marketing Organization

  8. Sep 27, 2006

    Amgen — NDA Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedAcceleratedSep 27, 2006

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only
Multi-specific
No

Oral

No

Parenteral

Yes

Topical

No

Black box warning

Sources

Also known as

  • abx-egf
  • abx-egf
  • abx-egf
  • abx-egf
  • abx-egf mab
  • abx-egf monoclonal antibody
  • amg 954
  • e7.6.3
  • immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer
  • l01xc08
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab
  • panitumumab antibody, human
  • vectibix
  • vectibix
  • vectibix
  • vectibix
  • vectibix

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06998940Phase 3Jan 6, 2026National Cancer Institute (NCI), SWOG Cancer Research Network
NCT07172919Phase 2Oct 20, 2025Amgen
NCT07124884Phase 2Aug 31, 2025Arbeitsgemeinschaft fur Internistische Onkologie (AIO), Federation Francophone de Cancerologie Digestive, Northwest Oncology Cooperative Group, Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
NCT07094113Phase 1Jul 31, 2025Amgen
NCT07094204Phase 1Jul 25, 2025Astellas
NCT06819228Early Phase 1 (Phase 1)Apr 17, 2025Vanderbilt University
NCT06820463Phase 2Mar 26, 2025AbbVie
NCT06967155Phase 2Mar 1, 2025Blokhin's Russian Cancer Research Center, Clinuvel Pharmaceuticals Limited, Government of Russia, The Loginov MCSC MHD
NCT06978400Phase 2Mar 1, 2025Blokhin's Russian Cancer Research Center, Clinuvel Pharmaceuticals Limited, Government of Russia, The Loginov MCSC MHD
NCT06714357Phase 2Dec 20, 2024Fondazione Giovanni Pascale
NCT06490536Phase 3Oct 22, 2024IFOM, Universidad Autonoma de Barcelona
NCT06245356Phase 2Oct 20, 2024Servier, UNICANCER
NCT06268015Phase 2Oct 1, 2024Agenus Inc., Duke University, Gateway for Cancer Research
NCT06252649Phase 3Jul 17, 2024Amgen
NCT06509126Phase 3Jun 12, 2024Fondazione Giovanni Pascale
NCT06194877Phase 1Apr 18, 2024MapKure, LLC
NCT06332079Phase 2Mar 13, 2024Gruppo Oncologico del Nord-Ovest, University of Pisa
NCT05901545Phase 1Dec 31, 2023American Cancer Society, Inc., Vanderbilt University
NCT05863195Phase 3Dec 19, 2023ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
NCT05945875Phase 1Nov 30, 2023National Cancer Institute (NCI), Vanderbilt University
Showing 20 of 240 trials
Page 1 / 12

Organizations

Research & Development (235)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AmgenFor profit1004142002
National Cancer Institute (NCI)Government26632000
Stanford UniversityAcademic/Hospital101022015
Duke UniversityAcademic/Hospital7722007
Gruppo Oncologico del Nord-OvestAcademic/Hospital7622010
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)Academic/Hospital7622007
NovartisFor profit6022007
Region SyddanmarkAcademic/Hospital6612008
University of Texas at HoustonAcademic/Hospital6612010
AIO-Studien-gGmbHFor profit5522009
ClinAssess GmbHFor profit5012011
Grupo Espanol Multidisciplinario del Cancer DigestivoAcademic/Hospital5512010
TakedaFor profit5422008
UNICANCERAcademic/Hospital5522010
University of BarcelonaAcademic/Hospital5122009
Vanderbilt UniversityAcademic/Hospital5522017
WiSP GmbHFor profit5412010
Clinica Universidad de NavarraAcademic/Hospital4022010
Cornell UniversityAcademic/Hospital4422011
Federation Francophone de Cancerologie DigestiveAcademic/Hospital4422012
235 organizations
Page 1 / 12

Marketing (3)

OrganizationOrg typeRelationshipDate
AmgenFor profitMKTGSep 27, 2006
AmgenFor profitNDASep 27, 2006
AmgenFor profitINDFeb 1, 2001