zalutumumab
mAbexperimental
Zalutumumab is a fully human IgG1 monoclonal antibody (mAb) directed towards the epidermal growth factor receptor (EGFR). It is a product developed by Genmab in Utrecht, the Netherlands. Specifically, zalutumumab is designed for the treatment of squamous cell carcinoma of the head and neck (SCCHN), a type of cancer. — Wikipedia
Clinical trial activity
10 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
10
Phase 3
2
Phase 4
0
Earliest trial started Dec 1, 2003 (NCT00093041)
Timeline
Indications
Mechanism of action
- Epidermal growth factor receptor erbB1ANTAGONIST
EGFR antagonist
Effectively blocks EGF-R signaling, and can potently induce Ab-dependent cell-mediated cytotoxicity (ADCC).
EGFR inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaZalutumumab ↗
- ChEMBLCHEMBL2107861 ↗
Also known as
- 2f8
- 2f8
- humax-egfr
- humax-egfr, 2f8
- zalutumumab
- zalutumumab
- zalutumumab
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01449357 | Phase 2 | Sep 29, 2011 | Genmab, University of South Florida |
| NCT01054625 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2010 | Genmab, Université catholique de Louvain |
| NCT00707655 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2008 | Genmab |
| NCT00677924 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2008 | Genmab |
| NCT00542308 | Phase 2 | Jan 1, 2008 | Genmab |
| NCT00496652 | Phase 3 | Nov 1, 2007 | Danish Head and Neck Cancer Group |
| NCT00460551 | Phase 2 | Apr 1, 2007 | Genmab |
| NCT00401401 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2006 | Genmab, Université catholique de Louvain |
| NCT00382031 | Phase 3 | Nov 1, 2006 | Genmab |
| NCT00093041 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2003 | Genmab |
Showing 10 of 10 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Genmab | For profit | 9 | 9 | 2 | 2003 |
| Université catholique de Louvain | Academic/Hospital | 2 | 0 | 1 | 2006 |
| Danish Head and Neck Cancer Group | Academic/Hospital | 1 | 1 | 1 | 2007 |
| University of South Florida | Academic/Hospital | 1 | 0 | 1 | 2011 |
4 organizations
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