tarloxotinib
Small moleculeexperimental
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2012 (NCT01631279)
Timeline
Indications
Mechanism of action
- Epidermal growth factor receptorINHIBITOR
Epidermal growth factor receptor inhibitor
HER2 most relevant for the indication NSCLC
Active against exon 20 mutated targets. HER2 most relevant for the indication NSCLC
EGFR inhibitor
ERBB2 inhibitor
ERBB4 inhibitor
- HERGINHIBITOR
KCNH2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cn1cnc([N+](=O)[O-])c1C[N+](C)(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(Cl)c(Br)c3)ncnc2cn1- Mol. weight
- 601.87 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL4297662 ↗
- ChEMBLCHEMBL4297661 ↗
Also known as
- pr610
- pr610
- tarloxotinib
- tarloxotinib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05313009 | Phase 1/Phase 2 (Phase 2) | Mar 7, 2022 | Medical University of South Carolina, Rain Therapeutics Inc. |
| NCT03805841 | Phase 2 | Mar 13, 2019 | Georgetown University, Rain Therapeutics Inc. |
| NCT02449681 | Phase 2 | Aug 1, 2015 | Georgetown University, Peter MacCallum Cancer Centre, Threshold Pharmaceuticals |
| NCT02454842 | Phase 2 | Jun 1, 2015 | Georgetown University, Threshold Pharmaceuticals |
| NCT01631279 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2012 | Proacta, Incorporated |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Georgetown University | Academic/Hospital | 3 | 0 | 1 | 2015 |
| Rain Therapeutics Inc. | For profit | 2 | 1 | 1 | 2019 |
| Threshold Pharmaceuticals | For profit | 2 | 2 | 1 | 2015 |
| Medical University of South Carolina | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Peter MacCallum Cancer Centre | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Proacta, Incorporated | For profit | 1 | 1 | 1 | 2012 |
6 organizations
Page 1 / 1