← Mechanisms of action
Glutamate [NMDA] receptor
PROTEIN COMPLEX GROUPHomo sapiens
Linked proteins
- Glutamate receptor ionotropic, NMDA 1 (GRIN1) ↗
- Glutamate receptor ionotropic, NMDA 2A (GRIN2A) ↗
- Glutamate receptor ionotropic, NMDA 2B (GRIN2B) ↗
- Glutamate receptor ionotropic, NMDA 2D (GRIN2D) ↗
- Glutamate receptor ionotropic, NMDA 3B (GRIN3B) ↗
- Glutamate receptor ionotropic, NMDA 2C (GRIN2C) ↗
- Glutamate receptor ionotropic, NMDA 3A (GRIN3A) ↗
Drugs acting on this target (18)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| acamprosate (campral) | Antagonist | approved | Small molecule | Glutamate [NMDA] receptor antagonist |
| amantadine (symmetrel) | Antagonist | approved | Small molecule | Glutamate [NMDA] receptor antagonist |
| azd8108 | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| felbamate (Felbatol) | Antagonist | approved | Small molecule | Glutamate [NMDA] receptor antagonist |
| gw 468816 | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| indantadol | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| l-4-cl-kyn | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| neramexane mesylate | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| orphenadrine hydrochloride (disipal) | Antagonist | approved | Small molecule | Glutamate [NMDA] receptor antagonist |
| perzinfotel | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| ralfinamide | Antagonist | experimental | Small molecule | Glutamate [NMDA] receptor antagonist |
| lanicemine | Blocker | experimental | Small molecule | Glutamate [NMDA] receptor blocker |
| esketamine (spravato) | Negative allosteric modulator | approved | Small molecule | Glutamate [NMDA] receptor negative allosteric modulator |
| ketamine (ketalar) | Negative allosteric modulator | approved | Small molecule | Glutamate [NMDA] receptor negative allosteric modulator |
| memantine (namenda) | Negative allosteric modulator | approved | Small molecule | Glutamate [NMDA] receptor negative allosteric modulator |
| nrx-1074 | Partial agonist | experimental | Small molecule | Glutamate [NMDA] receptor partial agonist |
| rapastinel | Partial agonist | experimental | Small molecule | Glutamate [NMDA] receptor partial agonist |
| neboglamine | Positive allosteric modulator | experimental | Small molecule | Glutamate [NMDA] receptor positive allosteric modulator |