stem cells
Cell therapyexperimental
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type. — Wikipedia
Clinical trial activity
204 trials · 142 clinical orgs · 0 marketing orgs
Phase 1
81
Phase 2
130
Phase 3
27
Phase 4
6
Earliest trial started Apr 1, 1993 (NCT00199069)
Timeline
Indications
Approved for
Studied for
- Acute Febrile Encephalopathy · Phase 2
- Adenocarcinoma, Clear Cell · Phase 1
- Adrenoleukodystrophy · Phase 2/Phase 3
- Allografts · Phase 1/Phase 2
- Alopecia · Phase 2
- alpha-Mannosidosis · Phase 2
- Amyotrophic Lateral Sclerosis · Phase 2
- Anemia, Aplastic · Phase 2/Phase 3
- Anemia, Diamond-Blackfan · Phase 2/Phase 3
- Anemia, Sickle Cell · Phase 3
- Arterial Occlusive Diseases · Phase 2
- Arthritis, Rheumatoid · Phase 1/Phase 2
- Aspartylglucosaminuria · Phase 2
- Astrocytoma · Early Phase 1
- Autism Spectrum Disorder · Phase 1/Phase 2
- Autistic Disorder · Phase 1/Phase 2
- Azoospermia · Phase 1/Phase 2
- Bone Marrow Cells · Phase 1/Phase 2
- Bone Marrow Transplantation · Phase 3
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Bulbar Palsy, Progressive · Phase 1/Phase 2
- Carcinoma, Renal Cell · Phase 2
- Cardiomyopathy, Dilated · Phase 2/Phase 3
- Cerebral Palsy · Phase 1/Phase 2
- Chagas Cardiomyopathy · Phase 3
- Chediak-Higashi Syndrome · Phase 2/Phase 3
- Choriocarcinoma · Phase 3
- Corneal Diseases · Phase 1
- Coronary Artery Disease · Phase 1
- Coronary Disease · Phase 1/Phase 2
- Crohn Disease · Phase 1/Phase 2
- Deficiency Diseases · Phase 2
- Diabetes Mellitus · Phase 2/Phase 3
- Dyskeratosis Congenita · Phase 2/Phase 3
- Endodermal Sinus Tumor · Phase 3
- Ependymoma · Early Phase 1
- Fanconi Anemia · Phase 1/Phase 2
- Fucosidosis · Phase 2/Phase 3
- Gangliosidosis, GM1 · Phase 2/Phase 3
- Gaucher Disease · Phase 2/Phase 3
- Genetic Diseases, Inborn · Phase 2
- Germinoma · Phase 3
- Glioma · Early Phase 1
- Graft vs Host Disease · Phase 2
- Granulomatous Disease, Chronic · Phase 2
- Hair · Phase 2/Phase 3
- Heart Failure · Phase 2/Phase 3
- Hematologic Diseases · Phase 2/Phase 3
- Hematologic Neoplasms · Phase 2
- Hematopoietic Stem Cells · Phase 1
- Hematopoietic Stem Cell Transplantation · Phase 2
- Hemoglobinopathies · Phase 2
- Hemoglobinuria, Paroxysmal · Phase 3
- Histiocytosis, Langerhans-Cell · Phase 2/Phase 3
- Hodgkin Disease · Phase 2
- Immune System Diseases · Phase 2/Phase 3
- Immunoglobulin Light-chain Amyloidosis · Phase 3
- Immunologic Deficiency Syndromes · Phase 2
- Infertility, Male · Phase 1/Phase 2
- Intellectual Disability · Phase 1
- Intestinal Neoplasms · Phase 1
- Kidney Neoplasms · Phase 2
- Leg Ulcer · Phase 1/Phase 2
- Leukemia · Phase 3
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 4
- Leukemia, Lymphoid · Phase 2
- Leukemia, Megakaryoblastic, Acute · Phase 1/Phase 2
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 2
- Leukemia, Myeloid, Acute · Phase 4
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative · Phase 3
- Leukemia, Myeloid, Chronic-Phase · Phase 1/Phase 2
- Leukemia, Myelomonocytic, Chronic · Phase 1/Phase 2
- Leukemia, Myelomonocytic, Juvenile · Phase 3
- Leukemia, Plasma Cell · Phase 2
- Leukemia, Prolymphocytic, T-Cell · Phase 1/Phase 2
- Leukodystrophy, Globoid Cell · Phase 2/Phase 3
- Leukodystrophy, Metachromatic · Phase 2/Phase 3
- Liver Cirrhosis · Phase 1/Phase 2
- Liver Neoplasms · Phase 1
- Lymphohistiocytosis, Hemophagocytic · Phase 3
- Lymphoma · Phase 2
- Lymphoma, B-Cell · Phase 1
- Lymphoma, B-Cell, Marginal Zone · Phase 1
- Lymphoma, Follicular · Phase 1
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Mantle-Cell · Phase 3
- Lymphoma, Non-Hodgkin · Phase 3
- Lymphoma, T-Cell · Phase 2
- Lymphoma, T-Cell, Cutaneous · Phase 1/Phase 2
- Lymphoma, T-Cell, Peripheral · Phase 1/Phase 2
- Lymphoproliferative Disorders · Phase 2/Phase 3
- Mannosidase Deficiency Diseases · Phase 2
- Melanoma · Phase 1
- Mesenchymal Stem Cell Transplantation · Phase 2
- Metabolic Diseases · Phase 2
- Motor Neuron Disease · Phase 1/Phase 2
- Mucopolysaccharidoses · Phase 2/Phase 3
- Mucopolysaccharidosis I · Phase 2
- Mucopolysaccharidosis II · Phase 2
- Mucopolysaccharidosis VI · Phase 2
- Mucopolysaccharidosis VII · Phase 2
- Mucositis · Phase 1/Phase 2
- Multiple Myeloma · Phase 4
- Muscular Atrophy, Spinal · Phase 1/Phase 2
- Muscular Dystrophies · Phase 1/Phase 2
- Muscular Dystrophies, Limb-Girdle · Phase 1
- Muscular Dystrophy, Duchenne · Phase 1/Phase 2
- Mutation · Phase 2
- Myelodysplastic-Myeloproliferative Diseases · Phase 2
- Myelodysplastic Syndromes · Phase 3
- Myeloproliferative Disorders · Phase 2
- Myocardial Infarction · Phase 3
- Myocardial Ischemia · Phase 1/Phase 2
- Neoplasms · Phase 3
- Neoplasms, Germ Cell and Embryonal · Phase 3
- Neoplasms, Plasma Cell · Phase 2
- Neuroblastoma · Phase 2/Phase 3
- Neuronal Ceroid-Lipofuscinoses · Phase 2/Phase 3
- Neutropenia · Phase 2/Phase 3
- Niemann-Pick Diseases · Phase 2/Phase 3
- Niemann-Pick Disease, Type B · Phase 2
- Niemann-Pick Disease, Type C · Phase 2
- Oligodendroglioma · Early Phase 1
- Optic Atrophy · Phase 1/Phase 2
- Optic Nerve Diseases · Phase 1/Phase 2
- Optic Nerve Glioma · Early Phase 1
- Osteoarthritis · Phase 1/Phase 2
- Osteoarthritis, Knee · Phase 2
- Osteopetrosis · Phase 2/Phase 3
- Ovarian Diseases · Phase 1
- Ovarian Neoplasms · Phase 2
- Pain · Phase 1/Phase 2
- Paraproteinemias · Phase 1/Phase 2
- Peripheral Arterial Disease · Phase 1/Phase 2
- Peripheral Blood Stem Cell Transplantation · Phase 1/Phase 2
- Peroxisomal Disorders · Phase 2
- Plasmacytoma · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 2
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 3
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1/Phase 2
- Preleukemia · Phase 1/Phase 2
- Pressure Ulcer · Phase 1
- Primary Immunodeficiency Diseases · Phase 1/Phase 2
- Primary Myelofibrosis · Phase 1
- Primary Ovarian Insufficiency · Phase 1/Phase 2
- Pulmonary Disease, Chronic Obstructive · Phase 1
- Pulpitis · Phase 3
- Refsum Disease, Infantile · Phase 2
- Retinoblastoma · Phase 1
- Rhabdoid Tumor · Phase 1
- Rhabdomyosarcoma · Phase 1
- Sandhoff Disease · Phase 2/Phase 3
- Sarcoma · Phase 1
- Sarcoma, Ewing · Phase 1
- Sarcoma, Myeloid · Phase 2
- Scleroderma, Systemic · Phase 2
- Seminoma · Phase 3
- Severe Combined Immunodeficiency · Phase 1
- Shwachman-Diamond Syndrome · Phase 2/Phase 3
- Sphingolipidoses · Phase 2
- Sphingomyelins · Phase 2
- ST Elevation Myocardial Infarction · Phase 2
- Stem Cell Transplantation · Phase 2
- Stomatitis · Phase 1/Phase 2
- Stroke · Phase 1/Phase 2
- Supranuclear Palsy, Progressive · Phase 1/Phase 2
- Tay-Sachs Disease · Phase 2/Phase 3
- Temporomandibular Joint Disorders · Phase 1/Phase 2
- Teratoma · Phase 3
- Testicular Neoplasms · Phase 2
- Thalassemia · Phase 2/Phase 3
- Transplantation · Phase 3
- Urological Manifestations · Phase 1
- Urologic Diseases · Phase 2/Phase 3
- Waldenstrom Macroglobulinemia · Phase 2/Phase 3
- Wilms Tumor · Phase 1
- Wiskott-Aldrich Syndrome · Phase 1/Phase 2
- Wolman Disease · Phase 2/Phase 3
- Wound Healing · Phase 1
- Wounds and Injuries · Phase 1
- Xerostomia · Phase 2
- X-Linked Combined Immunodeficiency Diseases · Phase 2
- Zellweger Syndrome · Phase 2
Mechanism of action
- Unspecified targetTissue restoration
tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaStem cell ↗
Also known as
- stem cell
- stem cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07005687 | N/A | Dec 1, 2025 | Shahid Beheshti University of Medical Sciences |
| NCT06986070 | Phase 1 | Jun 30, 2025 | SMSbiotech |
| NCT06947746 | N/A | May 1, 2025 | Second Military Medical University |
| NCT06326203 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2024 | Conselho Nacional de Desenvolvimento Científico e Tecnológico, Sao Paulo State University |
| NCT06391307 | N/A | May 11, 2024 | Esenyurt State Hospital, Necmi Kadıoğlu Hospital |
| NCT05210452 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2022 | Belarusian State Medical University, National Academy of Sciences of Belarus |
| NCT05305833 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2021 | Erciyes University |
| NCT04706312 | Phase 1 | Apr 30, 2021 | Nanjing Medical University |
| NCT04776538 | Phase 2 | Feb 9, 2021 | Aarhus University, University of Copenhagen |
| NCT04653077 | N/A | Dec 2, 2020 | Aljazeera Hospital, AMR KHALIL ORTHOPEDIC SURGERY CENTER |
| NCT04972890 | Phase 2/Phase 3 (Phase 3) | Oct 27, 2020 | University of Indonesia |
| NCT04393415 | N/A | May 20, 2020 | Aljazeera Hospital |
| NCT03308006 | Phase 2 | Dec 20, 2018 | King Faisal University |
| NCT03145402 | Phase 1/Phase 2 (Phase 2) | Sep 20, 2017 | Tabriz Medical University, University of Tabriz |
| NCT03295292 | Phase 1 | Aug 1, 2017 | L. V. Prasad Eye Institute |
| NCT02961816 | Phase 2 | Jun 1, 2017 | University of Texas at Houston |
| NCT02960646 | Phase 1 | Jan 18, 2017 | University of Texas at Houston |
| NCT02976441 | Early Phase 1 (Phase 1) | Jan 1, 2017 | Washington University in St. Louis |
| NCT03078621 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2016 | Stem Cells Arabia |
| NCT02865421 | Phase 2 | Sep 1, 2016 | King Edward Medical University |
Showing 20 of 204 trials
Page 1 / 11
Organizations
Research & Development (142)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Texas at Houston | Academic/Hospital | 48 | 48 | 3 | 1998 |
| University of Minnesota | Academic/Hospital | 21 | 21 | 4 | 1995 |
| Baylor University | Academic/Hospital | 14 | 12 | 4 | 2000 |
| St. Jude Children's Hospital | Academic/Hospital | 10 | 10 | 4 | 1997 |
| National Cancer Institute (NCI) | Government | 9 | 2 | 3 | 2000 |
| Washington University in St. Louis | Academic/Hospital | 9 | 9 | 2 | 2004 |
| Methodist Cancer Center, Houston, Texas | Academic/Hospital | 8 | 0 | 2 | 2000 |
| Neurogen Brain and Spine Institute | Academic/Hospital | 8 | 8 | 2 | 2008 |
| Harvard University | Academic/Hospital | 7 | 5 | 2 | 2002 |
| J. W. Goethe University | Academic/Hospital | 7 | 7 | 3 | 1993 |
| Celgene | For profit | 6 | 0 | 1 | 2008 |
| University of Chicago | Academic/Hospital | 6 | 5 | 3 | 2001 |
| Boston University | Academic/Hospital | 5 | 5 | 3 | 2001 |
| Stem Cells Arabia | Academic/Hospital | 5 | 5 | 1 | 2013 |
| Al Azhar University | Academic/Hospital | 4 | 3 | 1 | 2012 |
| Cairo University | Academic/Hospital | 4 | 0 | 1 | 2012 |
| Chaitanya Hospital | Academic/Hospital | 3 | 3 | 1 | 2014 |
| Cornell University | Academic/Hospital | 3 | 2 | 2 | 2008 |
| Duke University | Academic/Hospital | 3 | 2 | 2 | 2008 |
| Genzyme | For profit | 3 | 0 | 2 | 2006 |
142 organizations
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