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sodium citrate

Small moleculeapproved

Approved

Oct 3, 1980

Trisodium citrate is a chemical compound with the molecular formula Na3C6H5O7. It is sometimes referred to simply as "sodium citrate", though sodium citrate can refer to any of the three sodium salts of citric acid. It possesses a saline, mildly tart taste, and is a mild base. — Wikipedia

Clinical trial activity

41 trials · 51 clinical orgs · 5 marketing orgs

Phase 1
9
Phase 2
10
Phase 3
6
Phase 4
10

Earliest trial started Mar 1, 2003 (NCT00286273)

Timeline

1980s

  1. Oct 3, 1980

    B. Braun — Earliest FDA Approval

  2. Oct 3, 1980

    Evidence of US Marketing

  3. Oct 3, 1980

    B. Braun — NDA Secondary Org

  4. Oct 3, 1980

    B. Braun — NDA Organization

1990s

  1. Dec 10, 1997

    Alcon — NDA Secondary Org

  2. Dec 10, 1997

    Nestle — NDA Secondary Org

2000s

  1. Jan 1, 2006

    Earliest Phase 3 Sponsor(trial)

  2. Sep 27, 2006

    Akorn, Inc. — Marketing Organization

  3. Sep 27, 2006

    Epic Pharma Llc — Marketing Organization

  4. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

  5. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Feb 3, 2010

    B. Braun — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedOct 3, 1980
  • approvedOct 3, 1980

Chemistry & pharmacology

Loading structure…

SMILES

O=P([O-])([O-])O.[K+].[K+]
Mol. weight
174.17 g/mol
Chirality
Achiral Molecule
Inorganic
Yes
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • alka seltzer
  • alka seltzer
  • anhydrous sodium citrate
  • anticoagulant sodium citrate
  • canesten oasis
  • citra ph
  • cymalon
  • cymalon
  • cystemme
  • cystocalm
  • cystoleve
  • disodium citrate
  • disodium citrate
  • e331
  • e331
  • hydrous sodium citrate
  • isolyte
  • isolyte
  • isolyte e
  • micolette
  • micralax
  • potassium-sodium citrate
  • relaxit
  • sod cit
  • sodium citrate
  • sodium citrate
  • sodium citrate
  • sodium citrate
  • sodium citrate
  • sodium citrate
  • sodium citrate
  • sodium citrate
  • sodium citrate anhydrous
  • sodium citrate anhydrous
  • sodium citrate, anhydrous
  • sodium citrate, anhydrous
  • sodium citrate, anhydrous
  • sodium citrate dihydrate
  • sodium citrate dihydrate
  • trisodium citrate
  • trisodium citrate
  • trisodium citrate
  • trisodium citrate anhydrous
  • trisodium citrate anhydrous
  • trisodium citrate, anhydrous
  • trisodium citrate, anhydrous
  • trisodium citrate dihydrate
  • trisodium citrate dihydrate
  • trisodium citrate dihydrate
  • urisal
  • urisal
  • zuragen

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06994312N/AJul 1, 2025Jinlin University
NCT06538584Phase 1/Phase 2 (Phase 2)Sep 9, 2024University of Chicago
NCT06204432Phase 2Dec 1, 2023University of North Carolina at Chapel Hill
NCT05188339Phase 2/Phase 3 (Phase 3)Jul 20, 2022Chang Gung University
NCT04756427Phase 4Jan 31, 2022Johns Hopkins University
NCT05191290Phase 4Jan 21, 2022University of Ljubljana
NCT05154968Phase 1Nov 1, 2021Eli Lilly
NCT05067270Phase 1Oct 22, 2021Eli Lilly
NCT04802785Phase 2/Phase 3 (Phase 3)Jun 30, 2021lurye Clinic
NCT04792424N/AApr 1, 2021Chulalongkorn University
NCT04447781Phase 1/Phase 2 (Phase 2)Jul 15, 2020Coalition for Epidemic Preparedness Innovations, Inovio Pharmaceuticals, International Vaccine Institute, Seoul National University
NCT04139525N/ANov 1, 2019University of Ljubljana
NCT04284657Phase 2Jan 30, 2019University of Southern California
NCT03791190N/ASep 6, 2018People's Liberation Army of China
NCT06646328Phase 4Jun 9, 2018Hospital General Universitario de Castellón, Hospital Universitario de La Plana, University of Valencia
NCT03683563N/AApr 11, 2018University of Ljubljana
NCT03419923N/AOct 1, 2017Shantou University
NCT03281928N/AOct 1, 2017University of Chicago
NCT02905981Phase 2Oct 1, 2016Rockwell Medical Inc
NCT02767128Phase 1Apr 1, 2016Rockwell Medical Inc
Showing 20 of 41 trials
Page 1 / 3

Organizations

Research & Development (51)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Eyegate Pharmaceuticals, Inc.For profit4422008
University of LjubljanaAcademic/Hospital3322018
Chulalongkorn UniversityAcademic/Hospital2122005
Eli LillyFor profit2212021
Rockwell Medical IncFor profit2222016
University of ChicagoAcademic/Hospital2222017
Andover Eye AssociatesAcademic/Hospital1012010
Ash Access TechnologyFor profit1112006
BayerFor profit1112010
Catholic University of PelotasAcademic/Hospital1112012
Center For Excellence In Eye CareAcademic/Hospital1012012
Chang Gung UniversityAcademic/Hospital1112022
Chiangmai UniversityAcademic/Hospital1012005
Coalition for Epidemic Preparedness InnovationsAcademic/Hospital1012020
Erasmus University RotterdamAcademic/Hospital1112009
Fundação de Amparo à Pesquisa do Estado de São PauloAcademic/Hospital1012013
GlaxoSmithKlineFor profit1112016
Hazleton Eye SpecialistsAcademic/Hospital1012007
Hospital General Universitario de CastellónAcademic/Hospital1012018
Hospital Universitario de La PlanaAcademic/Hospital1012018
51 organizations
Page 1 / 3

Marketing (7)

OrganizationOrg typeRelationshipDate
Akorn, Inc.For profitMKTGSep 27, 2006
AlconFor profitNDA2Dec 10, 1997
B. BraunFor profitNDA2Oct 3, 1980
B. BraunFor profitMKTGFeb 3, 2010
B. BraunFor profitNDAOct 3, 1980
Epic Pharma LlcFor profitMKTGSep 27, 2006
NestleFor profitNDA2Dec 10, 1997