oxiglutatione
Approved
Jul 24, 2008
Oxiglutathione is the oxidized disulfide form of glutathione (GSH) with potential protective activity. Glutathione disulfide (GSSG) is reduced by glutathione reductase to GSH. GSSG and GSH together play important roles in numerous redox reactions, such as those involved in the detoxification of harmful substances and free radicals, and in reactions preventing oxidative damage in erythrocytes. Upon ocular administration in irrigation solution, glutathione disulfide may exert a beneficial effect on the intracellular redox state of glutathione, thereby protecting the integrity and barrier function of the corneal endothelial cells. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Timeline
Indications
Approved for
Mechanism of action
- Glutathione reductaseSUBSTRATE
GSR substrate
Combination products
Approval history
- approvedJul 24, 2008
Chemistry & pharmacology
SMILES
[H+].[H+].[Na+].[Na+].N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C([O-])=O)C(=O)NCC([O-])=O)C(=O)NCC([O-])=O)C([O-])=O- Mol. weight
- 656.595 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaGlutathione disulfide ↗
- NCATSGY131TX61G ↗
- ChEMBLCHEMBL1372 ↗
Also known as
- nov002
- nov 002
- nov-002
- nov-002
- nov-002
- nov-002
- oxidized glutathione
- oxidized glutathione
- oxiglutatione
- oxiglutatione
- oxiglutatione
- oxiglutatione
- oxiglutatione
- oxiglutatione
- oxiglutatione