Adrenal Hyperplasia, Congenital
A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
Drugs by status
Approved for this indication (9)
Phase 4 trials (2)
Phase 3 trials (1)
Phase 2 trials (8)
Phase 1 trials (2)
Other trials (2)
Organizations
Organization Involved with Phase 4 Indications (2)
Organization Involved with Phase 3 Indications (3)
Organization Involved with Phase 2 Indications (12)
- Millendo Therapeutics, Inc.
- National Center for Research Resources (NCRR)
- Harvard University
- University of Michigan
- University of Bergen
- University of California, San Diego
- Feinstein Institute for Medical Research
- University of Minnesota
- Helse Bergen
- Spruce Biosciences
- Children's Hospital Los Angeles
- The University of Texas, Dallas
Organization Involved with Phase 1 Indications (3)
Organization Involved with Other Experimental Indications (2)