← Mechanisms of action
SLC6A2
SINGLE PROTEINHomo sapiens
Preferred name: Norepinephrine transporter ChEMBL ↗
Linked proteins
Drugs acting on this target (63)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| amitriptylinoxide | Antagonist | experimental | Small molecule | SC6A2 antagonist |
| doxepin (sinequan) | Antagonist | approved | Small molecule | SLC6A2 antagonist |
| rauwolfia alkaloids | Antagonist | approved | Small molecule | SC6A2 antagonist |
| amitifadine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| amitriptyline (elavil) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| amoxapine (asendin) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| ampreloxetine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| ansofaxine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| ar-13324 | Inhibitor | experimental | Small molecule | SC6A2 inhibitor |
| atomoxetine (strattera) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| bupropion (wellbutrin) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| desipramine (pertofrane) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| desvenlafaxine (pristiq) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| dexmethylphenidate (focalin) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| dibenzepin hydrochloride | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| diethylpropion hydrochloride (tenuate) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| dosulepin (Prothiaden) | Inhibitor | experimental | Small molecule | Norepinephrine transporter inhibitor |
| duloxetine (Cymbalta) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| edivoxetine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| esreboxetine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| faxeladol | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| gsk372475 | Inhibitor | experimental | Small molecule | SC6A2 inhibitor |
| imipramine (tofranil) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| isocaramidine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| levomilnacipran (fetzima) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| maprotiline (ludiomil) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| methylphenidate (ritalin) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| methylreboxetine | Inhibitor | experimental | Small molecule | SC6A2 inhibitor |
| milnacipran (savella) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| nefazodone (serzone) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| nortriptyline (aventyl) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| orphenadrine hydrochloride (disipal) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| phendimetrazine (plegine) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| phenmetrazine (preludin) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| protriptyline (vivactil) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| radafaxine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| reboxetine (Edronax) | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| sep-228432 | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| serdexmethylphenidate (AZSTARYS) | Inhibitor | approved | Small molecule | Norepinephrine transporter inhibitor |
| solriamfetol (Sunosi) | Inhibitor | approved | Small molecule | SC6A2 inhibitor |
| tac-302 | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| tapentadol (nucynta) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| tas-303 | Inhibitor | experimental | Small molecule | SC6A2 inhibitor |
| tedatioxetine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| trimipramine (surmontil) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| tyramine | Inhibitor | experimental | Small molecule | SLC6A2 inhibitor |
| venlafaxine (effexor) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| venlaxafine (Effexor) | Inhibitor | approved | Small molecule | SLC6A2 inhibitor |
| viloxazine (Qelbree) | Inhibitor | approved | Small molecule | Norepinephrine transporter inhibitor |
| xtl-2125 | Inhibitor | experimental | Small molecule | SC6A2 inhibitor |
| 3,4-Methylenedioxymethamphetamine | Releasing agent | experimental | Small molecule | Sodium-dependent noradrenaline transporter releasing agent |
| amphetamine (Adderall) | Releasing agent | approved | Small molecule | SLC6A2 releasing agent |
| benzphetamine (didrex) | Releasing agent | approved | Small molecule | SLC6A2 releasing agent |
| dextroamphetamine (Dexedrine) | Releasing agent | approved | Small molecule | SLC6A2 releasing agent |
| lisdexamfetamine (vyvanse) | Releasing agent | approved | Small molecule | SLC6A2 releasing agent |
| phentermine (wyamine) | Releasing agent | approved | Small molecule | SLC6A2 releasing agent |
| phenylpropanolamine (Propadrine) | Releasing agent | withdrawn | Small molecule | SLC6A2 releasing agent |
| pseudoephedrine (Benylin) | Releasing agent | approved | Small molecule | SLC6A2 releasing agent |
| bethanidine (tenathan) | Substrate | approved | Small molecule | SLC6A2 substrate |
| bretylium (Bretylol) | Substrate | approved | Small molecule | SLC6A2 substrate |
| guanadrel (hylorel) | Substrate | approved | Small molecule | SLC6A2 substrate |
| guanethidine (ismelin) | Substrate | approved | Small molecule | SLC6A2 substrate |
| iobenguane sulfate i-131 (iobenguane sulfate i-131) | Substrate | approved | Small molecule | Norepinephrine transporter substrate |