venlaxafine
Trade name: Effexor
Approved
Jun 1, 1993
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. Studies have shown that venlafaxine improves post-traumatic stress disorder (PTSD) as a recommended first-line treatment. It may also be used for chronic neuropathic pain. It is taken orally. It is also available as the salt venlafaxine besylate in an extended-release formulation. — Wikipedia
Clinical trial activity
6 trials · 8 clinical orgs · 1 marketing orgs
Earliest trial started Jan 1, 2002 (NCT01352572)
Timeline
Indications
Mechanism of action
- Serotonin transporterINHIBITOR
SLC6A4 inhibitor
- Unspecified targetINHIBITOR
Inhibitor
- Norepinephrine transporterINHIBITOR
SLC6A2 inhibitor
- Unspecified targetOTHER
Unknown
Approval history
- approvedJun 1, 1993
Chemistry & pharmacology
SMILES
COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1.O=S(=O)(O)c1ccccc1- Mol. weight
- 435.59 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaVenlafaxine ↗
- ChEMBLCHEMBL5095051 ↗
Also known as
- venlaxafine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03538691 | Phase 3 | Jul 13, 2018 | Otsuka |
| NCT03434041 | Phase 3 | May 25, 2018 | Johnson and Johnson |
| NCT01557712 | Phase 3 | Mar 1, 2012 | University of Grenoble |
| NCT00974155 | Phase 4 | Sep 1, 2009 | German Federal Ministry of Education and Research, Johannes Gutenburg University |
| NCT00612807 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2006 | Duke University, National Institutes of Health (NIH) |
| NCT01352572 | N/A | Jan 1, 2002 | Sungkyunkwan University |
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Duke University | Academic/Hospital | 1 | 1 | 1 | 2006 |
| German Federal Ministry of Education and Research | Government | 1 | 0 | 1 | 2009 |
| Johannes Gutenburg University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Johnson and Johnson | For profit | 1 | 1 | 1 | 2018 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2006 |
| Otsuka | For profit | 1 | 1 | 1 | 2018 |
| Sungkyunkwan University | Academic/Hospital | 1 | 1 | 1 | 2002 |
| University of Grenoble | Academic/Hospital | 1 | 1 | 1 | 2012 |