edivoxetine

Small moleculeexperimental

Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and was under development by Eli Lilly for attention-deficit disorder (ADD) and as an antidepressant treatment. It was in phase III clinical trials in 2012 for major depressive disorder, but failed to get approval. — Wikipedia

Clinical trial activity

27 trials · 1 clinical orgs · 0 marketing orgs

Phase 1
16
Phase 2
8
Phase 3
9
Phase 4
0

Earliest trial started Dec 1, 2006 (NCT00420004)

Timeline

2000s

  1. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2010

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2010

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc(F)cc1C[C@@](O)(C1CCOCC1)[C@@H]1CNCCO1
Mol. weight
339.41 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • alpha-((5-fluoro-2-methoxyphenyl)methyl)-alpha-(tetrahydro-2h-pyran-4-yl)-2-morpholinemethanol
  • edivoxetine
  • edivoxetine
  • edivoxetine
  • edivoxetine
  • ly2216684
  • ly2216684
  • ly2216684
  • ly 2216684
  • ly-2216684
  • ly-2216684
  • ly-2216684

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT00965419Phase 2/Phase 3 (Phase 3)Aug 1, 2014Eli Lilly
NCT01460381Phase 1Oct 1, 2011Eli Lilly
NCT01460407Phase 1Oct 1, 2011Eli Lilly
NCT01370499Phase 3Aug 1, 2011Eli Lilly
NCT01389752Phase 1Jul 1, 2011Eli Lilly
NCT01389765Phase 1Jul 1, 2011Eli Lilly
NCT01380691Phase 1Jun 1, 2011Eli Lilly
NCT01373931Phase 1Jun 1, 2011Eli Lilly
NCT01299272Phase 3May 1, 2011Eli Lilly
NCT01185340Phase 3Mar 1, 2011Eli Lilly
NCT01187407Phase 3Mar 1, 2011Eli Lilly
NCT01263106Phase 1Dec 1, 2010Eli Lilly
NCT01263093Phase 1Dec 1, 2010Eli Lilly
NCT01263119Phase 1Dec 1, 2010Eli Lilly
NCT01263197Phase 1Dec 1, 2010Eli Lilly
NCT01263223Phase 1Dec 1, 2010Eli Lilly
NCT01266590Phase 1Dec 1, 2010Eli Lilly
NCT01275144Phase 1Dec 1, 2010Eli Lilly
NCT01250873Phase 1Nov 1, 2010Eli Lilly
NCT01173601Phase 3Nov 1, 2010Eli Lilly
Showing 20 of 27 trials
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Organizations

Research & Development (1)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Eli LillyFor profit272732006
1 organizations
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