benzphetamine

Trade name: didrex

Small moleculeapproved

Approved

Oct 26, 1960

Benzphetamine, sold under the brand name Didrex among others, is an amphetamine-type stimulant and appetite suppressant used short-term for weight loss along with a doctor-approved, reduced-calorie diet, exercise, and behavioral program. It is prescribed for obesity to people who have been unable to lose weight through exercise and dieting alone. It is a prodrug of dextromethamphetamine and dextroamphetamine. — Wikipedia

Clinical trial activity

0 trials · 0 clinical orgs · 15 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1960s

Oct 26, 1960
Upjohn — Earliest FDA Approval
Oct 26, 1960
Pharmacia & Upjohn — NDA Secondary Org
Oct 26, 1960
Pfizer — Marketing Organization
Oct 26, 1960
Upjohn — NDA Organization
Oct 26, 1960
Pfizer — NDA Secondary Org

2000s

Apr 17, 2006
TWi Biotechnology, Inc. — Marketing Organization
Apr 17, 2006
ScinoPharm Taiwan — Marketing Organization
Mar 30, 2007
Tedor Pharm — Marketing Organization
Apr 25, 2007
Specgx Llc — Marketing Organization
Oct 29, 2007
Epic Pharma Llc — Marketing Organization
Nov 18, 2008
Impax Laboratories — Marketing Organization

2010s

Jul 20, 2010
Kvk Tech Inc — Marketing Organization
Sep 15, 2010
Mikart — Marketing Organization
Sep 15, 2010
Chartwell Pharmaceuticals — Marketing Organization
Sep 15, 2010
ANDA Repository — Marketing Organization
Jan 27, 2012
Emcure — Marketing Organization
Jan 27, 2012
Avet Lifesciences — Marketing Organization

Indications

Approved for

Obesity (approved 2006)

Mechanism of action

Synaptic vesicular amine transporterINHIBITOR
SLC18A2 inhibitor
- Synaptic vesicular amine transporter (SLC18A2) ↗
Norepinephrine transporterRELEASING AGENT
SLC6A2 releasing agent
- Sodium-dependent noradrenaline transporter (SLC6A2) ↗

Approval history

approvedOct 26, 1960

Chemistry & pharmacology

Loading structure…

SMILES

C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1

Mol. weight: 239.36 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Prescription Only

Oral

Yes

Parenteral

Topical

Sources

Also known as

(alphas)-n,alpha-dimethylphenethylamine
(alphas)-n,alpha-dimethylphenethylamine
benzaphetamine
benzaphetamine
benzfetamina
benzfetamina
benzfetamine
benzfetamine
benzfetamine
benzfetaminum
benzfetaminum
benzphetamine
benzphetamine
benzphetamine
benzphetamine
benzphetamine
benzphetamine
benzphetamine
benzphetamine
(+)-benzphetamine
(+)-benzphetamine
(+)-benzphetamine
benzphetamine chloride
benzphetamine chloride
benzphetamine hcl
benzphetamine hcl
benzphetamine hcl
benzphetamine hydrochloride
benzphetamine hydrochloride
benzphetamine hydrochloride
benzphetamine hydrochloride
benzylamphetamine
benzylamphetamine
benzylamphetamine
benzylamphetamine, (-)-isomer
benzylamphetamine, (+)-isomer
desmethylbenzphetamine
didrex
didrex
didrex
d-n-methyl-n-benzyl-beta-phenylisopropylamine
d-n-methyl-n-benzyl-beta-phenylisopropylamine
d-n-methyl-n-benzyl-β-phenylisopropylamine
d-n-methyl-n-benzyl-β-phenylisopropylamine
(+)-n,alpha-dimethyl-n-(phenylmethyl)-benzeneethanamine
(+)-n,alpha-dimethyl-n-(phenylmethyl)-benzeneethanamine
n-benzylamphetamine
(+)-n-benzyl-n,alpha-dimethylphenethylamine
(+)-n-benzyl-n,alpha-dimethylphenethylamine
(+)-n-benzyl-n,α-dimethylphenethylamine
(+)-n-benzyl-n,α-dimethylphenethylamine
n-methyl-1-phenyl-n-(phenylmethyl)propan-2-amine
n-methyl-1-phenyl-n-(phenylmethyl)propan-2-amine
(+)-n,α-dimethyl-n-(phenylmethyl)-benzeneethanamine
(+)-n,α-dimethyl-n-(phenylmethyl)-benzeneethanamine
(s)-benzphetamine
(s)-benzphetamine
(s)-benzphetamine
(s)-(+)-benzphetamine
(s)-(+)-benzphetamine
(s)-(+)-n-benzyl-n,alpha-dimethylphenethylamine
(s)-(+)-n-benzyl-n,alpha-dimethylphenethylamine
(s)-(+)-n-benzyl-n,α-dimethylphenethylamine
(s)-(+)-n-benzyl-n,α-dimethylphenethylamine

Organizations

Marketing (16)

Organization	Org type	Relationship	Date
ANDA Repository	For profit	MKTG	Sep 15, 2010
Avet Lifesciences	For profit	MKTG	Jan 27, 2012
Chartwell Pharmaceuticals	For profit	MKTG	Sep 15, 2010
Emcure	For profit	MKTG	Jan 27, 2012
Epic Pharma Llc	For profit	MKTG	Oct 29, 2007
Impax Laboratories	For profit	MKTG	Nov 18, 2008
Kvk Tech Inc	For profit	MKTG	Jul 20, 2010
Mikart	For profit	MKTG	Sep 15, 2010
Pfizer	For profit	MKTG	Oct 26, 1960
Pfizer	For profit	NDA2	Oct 26, 1960
Pharmacia & Upjohn	For profit	NDA2	Oct 26, 1960
ScinoPharm Taiwan	For profit	MKTG	Apr 17, 2006
Specgx Llc	For profit	MKTG	Apr 25, 2007
TWi Biotechnology, Inc.	For profit	MKTG	Apr 17, 2006
Tedor Pharm	For profit	MKTG	Mar 30, 2007
Upjohn	For profit	NDA	Oct 26, 1960