phenmetrazine

Trade name: preludin

Small moleculeapproved

Phenmetrazine is an anti-obesity drug, which was discovered by Boehringer-Ingelheim in 1952 and approved by FDA under the name Preludin. Later on the drug was withdrawn from the market due to the reported cases of abuse. According to some studies, misuse of phenmetrazine turned many young addicts to crime. It is suggested that the drug exerts its effect by inhibiting the monoamine transport. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Jun 1, 1956
Boehringer Ingelheim — First NDA Organization
Jun 1, 1956
Boehringer Ingelheim — NDA Organization

Indications

Approved for

Obesity

Mechanism of action

Dopamine transporterINHIBITOR
SLC6A3 inhibitor
- Sodium-dependent dopamine transporter (SLC6A3) ↗
Norepinephrine transporterINHIBITOR
SLC6A2 inhibitor
- Sodium-dependent noradrenaline transporter (SLC6A2) ↗

Approval history

approved—

Chemistry & pharmacology

Loading structure…

SMILES

CC1NCCOC1c1ccccc1

Mol. weight: 177.25 g/mol
Lipinski Ro5: Pass
Rule of 3: Yes
Chirality: Racemic Mixture
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Discontinued

Oral

Yes

Parenteral

Topical

Sources

Also known as

2-phenyl-3-methylmorpholine
2-phenyl-3-methylmorpholine
3-methyl-2-phenylmorpholine
3-methyl-2-phenyltetrahydro-2h-1,4-oxazine
fenmetrazin
fenmetrazin
fenmetrazina
fenmetrazina
fenmetrazina
fenmetrazine
oxazimedrine
phenmetraline hcl
phenmetraline hcl
phenmetrazin
phenmetrazin
phenmetrazin
phenmetrazine
phenmetrazine
phenmetrazine
phenmetrazine
phenmetrazine
phenmetrazine
phenmetrazine
phenmetrazine
phenmetrazine chloride
phenmetrazine chloride
phenmetrazine hcl
phenmetrazine hcl
phenmetrazine hcl
phenmetrazine hydrochloride
phenmetrazine hydrochloride
phenmetrazine hydrochloride
phenmetrazine hydrochloride
phenmetrazine teoclate
phenmetrazine teoclate
phenmetrazine teoclate
phenmetrazine teoclate
phenmetrazine teoclate
phenmetrazine teoclate
phenmetrazinum
phenmetrazinum
preludin
preludin
preludin

Organizations

Marketing (1)

Organization	Org type	Relationship	Date
Boehringer Ingelheim	For profit	NDA	Jun 1, 1956