bethanidine
Trade name: tenathan
Small moleculeapproved
Approved
May 29, 1981
Bethanidine is a post-ganglionic adrenergic neurone-blocking agent which exerts a marked postural hypotensive effect. The precise mechanism whereby bethanidine causes blockade of adrenergic neurones is unknown. An initial sympathomimetic effect has been demonstrated in man and animals, possibly due to release of catecholamines. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
Indications
Approved for
Mechanism of action
- Norepinephrine transporterSUBSTRATE
SLC6A2 substrate
accumulates and displaces NE
Approval history
- approvedMay 29, 1981
Chemistry & pharmacology
Loading structure…
SMILES
CNC(NC)=NCC1=CC=CC=C1- Mol. weight
- 177.2462 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBethanidine ↗
- NCATSW8S3YM7AUU ↗
- ChEMBLCHEMBL2110368 ↗
- ChEMBLCHEMBL2104771 ↗
- ChEMBLCHEMBL1201260 ↗
- ChEMBLCHEMBL1095607 ↗
Also known as
- bendogen
- bendogen
- betanidina
- betanidina
- betanidine
- betanidine
- betanidine
- betanidine
- betanidine
- betanidine sulfate
- betanidine sulfate
- betanidinum
- betanidinum
- bethanidine
- bethanidine
- bethanidine
- bethanidine
- bethanidine
- bethanidine
- bethanidine
- bethanidine sulfate
- bethanidine sulfate
- bethanidine sulfate
- bethanidine sulfate
- bw-467-c-60
- bw-467-c-60
- esbatal
- esbatal
- esbatal
- esbatal
- esbatal
- esbatal
- n,n'-dimethyl-n''-(phenylmethyl)-guanidine
- n,n'-dimethyl-n''-(phenylmethyl)-guanidine
- tenathan
- tenathan
- tenathan
Organizations
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| AH Robins | For profit | NDA | May 29, 1981 |