CDEK by Data4ThePeople
Sign in Sign up
← All drugs Report issue

reboxetine

Trade name: Edronax

Small moleculeexperimental

Reboxetine, sold under the brand name Edronax among others, is a selective norepinephrine reuptake inhibitor (sNRI) medication marketed as an antidepressant by Pfizer for use in the treatment of major depressive disorder, although it has also been used off-label for panic disorder and attention deficit hyperactivity disorder (ADHD). It is approved for use in many countries worldwide, but is not approved for use in the United States. — Wikipedia

Clinical trial activity

26 trials · 31 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
13
Phase 3
6
Phase 4
4

Earliest trial started Jun 1, 2004 (NCT00636246)

Timeline

2000s

  1. Jan 1, 2004

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2012

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Norepinephrine transporterINHIBITOR

    SLC6A2 inhibitor

    It acts by binding to the norepinephrine transporter and blocking reuptake of extracellular norepinephrine (noradrenaline) back into the terminals. A meta-analysis showed that reboxetine (marketed by Pfizer in Europe, but not in the U.S. ) lacks efficacy.

    High selectivity for NET over SERT/DAT. Low affinity for monoamine/histamine/ACh receptors

Chemistry & pharmacology

Loading structure…

SMILES

CCOc1ccccc1OC(c1ccccc1)C1CNCCO1
Mol. weight
313.4 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Delivery
Oral

Oral

Yes

Parenteral

No

Topical

No

Sources

Also known as

  • 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate
  • edronax
  • edronax
  • edronax
  • norebox
  • reboxetine
  • reboxetine
  • reboxetine
  • reboxetine
  • reboxetine
  • reboxetine
  • reboxetine
  • reboxetine
  • reboxetine mesilate
  • reboxetine mesilate
  • reboxetine mesilate
  • reboxetine mesilate
  • reboxetine mesilate
  • reboxetine mesylate
  • reboxetine mesylate
  • reboxitine
  • vestra

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05978505Phase 2Aug 15, 2023Flinders University
NCT05880342Phase 3May 3, 2023Free University of Brussels, Science and Research Centre Koper
NCT05133804Phase 2Dec 1, 2021Lev HaSharon Mental Health Center, University of Haifa
NCT05113745Phase 3Oct 20, 2021Axsome Therapeutics, Inc.
NCT05059223Phase 3Sep 15, 2021Axsome Therapeutics, Inc.
NCT04449133Phase 2Jul 3, 2020Apnimed, Inc., Bioikos Ambiente Srl, Istituto Auxologico Italiano, STM Pharma PRO srl
NCT04394143Phase 2/Phase 3 (Phase 3)Jun 1, 2020Apnimed, Inc., University of Lausanne
NCT04384562N/AJun 1, 2020University of Zurich
NCT04097288Phase 1Sep 17, 2019University of Copenhagen
NCT04371146N/AJul 3, 2019University of Zurich
NCT03957174N/AJun 30, 2019University of Oxford
NCT03881852Phase 2Jan 30, 2019Axsome Therapeutics, Inc.
NCT02374567Phase 3Jan 1, 2015Gottfried Wilhelm Leibniz Universität Hannover
NCT02179268Phase 3Mar 1, 2012Guizhou Medical University, World Health Organization
NCT00886886Phase 1Apr 1, 2009University of Basel, University of Bern
NCT00853866Phase 4Jan 1, 2009German Research Foundation, University of Hamburg, University of Tuebingen
NCT01300364Phase 4Nov 1, 2008Centro de Investigación Biomédica en Red (CIBER), Fundació Sant Joan de Déu
NCT00562055Phase 2Nov 1, 2007Pfizer
NCT00421369N/ASep 1, 2007Hebrew University
NCT00409201Phase 1Mar 1, 2006Abarbanel Mental Health Center, Center Abarbanel Mental Health
Showing 20 of 26 trials
Page 1 / 2

Organizations

Research & Development (31)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
PfizerFor profit4412004
Axsome Therapeutics, Inc.For profit3322019
Apnimed, Inc.For profit2022020
German Research FoundationAcademic/Hospital2022005
University of ZurichAcademic/Hospital2212019
Abarbanel Mental Health CenterAcademic/Hospital1112006
Bioikos Ambiente SrlFor profit1012020
Center Abarbanel Mental HealthAcademic/Hospital1012006
Centro de Investigación Biomédica en Red (CIBER)Academic/Hospital1012008
Flinders UniversityAcademic/Hospital1112023
Free University of BrusselsAcademic/Hospital1112023
Fundació Sant Joan de DéuAcademic/Hospital1112008
Gottfried Wilhelm Leibniz Universität HannoverAcademic/Hospital1112015
Guizhou Medical UniversityAcademic/Hospital1112012
Hebrew UniversityAcademic/Hospital1112007
Istituto Auxologico ItalianoAcademic/Hospital1112020
Lev HaSharon Mental Health CenterAcademic/Hospital1012021
Science and Research Centre KoperAcademic/Hospital1012023
STM Pharma PRO srlFor profit1012020
Technion UniversityAcademic/Hospital1112005
31 organizations
Page 1 / 2