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esreboxetine

Small moleculeexperimental

Esreboxetine (developmental code names AXS-14, PNU-165442G) is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued. It is the (S,S)-(+)-enantiomer of reboxetine and is even more selective as a norepinephrine reuptake inhibitor in comparison. — Wikipedia

Clinical trial activity

17 trials · 1 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
14
Phase 3
4
Phase 4
0

Earliest trial started Dec 1, 2003 (NCT00143442)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCOc1ccccc1O[C@@H](c1ccccc1)[C@@H]1CNCCO1
Mol. weight
313.4 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • (+)-(2s)-2-((s)-(2-ethoxyphenoxy)phenylmethyl)morpholine
  • esreboxetine
  • esreboxetine
  • esreboxetine
  • esreboxetine
  • esreboxetine
  • (s,s)-reboxetine
  • (s,s)-reboxetine
  • [s,s]-reboxetine
  • [s,s]-reboxetine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT00796601Phase 3May 1, 2009Pfizer
NCT00800956Phase 1Jan 1, 2009Pfizer
NCT00809289Phase 1Dec 1, 2008Pfizer
NCT00752505Phase 2Aug 1, 2008Pfizer
NCT00754221Phase 3May 1, 2008Pfizer
NCT00612170Phase 3Dec 1, 2007Pfizer
NCT00625833Phase 2Dec 1, 2007Pfizer
NCT00607256Phase 3Oct 1, 2007Pfizer
NCT00444548N/AMay 1, 2007Pfizer
NCT00354094Phase 2Nov 1, 2006Pfizer
NCT00357825Phase 2Aug 1, 2006Pfizer
NCT00348894Phase 2Jul 1, 2006Pfizer
NCT00334685Phase 2Jul 1, 2006Pfizer
NCT00353808Phase 2Jul 1, 2006Pfizer
NCT00288652Phase 2Mar 1, 2006Pfizer
NCT00636246Phase 2Jun 1, 2004Pfizer
NCT00143442Phase 2Dec 1, 2003Pfizer
Showing 17 of 17 trials
Page 1 / 1

Organizations

Research & Development (1)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
PfizerFor profit171742003
1 organizations
Page 1 / 1