autologous hematopoietic stem cells
Cell therapyexperimental
Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells. Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. PBSCT is now a much more common procedure than its bone marrow harvest equivalent due to the ease and less invasive nature of the procedure. Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell yield. — Wikipedia
Clinical trial activity
618 trials · 289 clinical orgs · 0 marketing orgs
Phase 1
190
Phase 2
467
Phase 3
96
Phase 4
1
Earliest trial started Apr 1, 1988 (NCT00002461)
Timeline
Indications
Approved for
Studied for
- Acne Vulgaris · Phase 2
- alpha-Thalassemia · Early Phase 1
- Amyloidosis · Phase 3
- Anemia · Phase 2
- Anemia, Aplastic · Phase 2
- Anemia, Diamond-Blackfan · Phase 2
- Anemia, Refractory · Phase 2
- Antigens, CD20 · Phase 1
- Antiphospholipid Syndrome · Phase 1
- Arthritis, Rheumatoid · Phase 1
- Autoimmune Diseases · Phase 2
- Autoimmune Diseases of the Nervous System · Phase 2
- beta-Thalassemia · Phase 1/Phase 2
- Bone Marrow Cells · Phase 2
- Bone Marrow Failure Disorders · Phase 2
- Brain Neoplasms · Phase 3
- Breast Neoplasms · Phase 3
- Breast Neoplasms, Male · Phase 2
- Bronchopulmonary Dysplasia · Phase 1
- Burkitt Lymphoma · Phase 3
- Carcinoma · Phase 2
- Cardiomyopathies · Phase 1/Phase 2
- Cartilage Diseases · Phase 2
- Central Nervous System Neoplasms · Phase 3
- Cerebellar Ataxia · Phase 2
- Cerebellar Diseases · Phase 2
- Cerebral Palsy · Phase 2
- Chordoma · Phase 1
- Chromosome Aberrations · Phase 2
- Chronic Disease · Phase 2
- Colonic Neoplasms · Phase 1
- Colorectal Neoplasms · Phase 1/Phase 2
- Coronary Artery Bypass · Phase 1/Phase 2
- Crohn Disease · Phase 2
- Diabetes Mellitus, Type 1 · Phase 2
- Diffuse Intrinsic Pontine Glioma · Phase 1
- Diploidy · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 2
- Encephalitis · Phase 2
- Endocrine System Diseases · Phase 1/Phase 2
- Fallopian Tube Neoplasms · Phase 2
- Fanconi Anemia · Phase 2
- Glioblastoma · Phase 2/Phase 3
- Glioma · Phase 1
- Gliosarcoma · Phase 1/Phase 2
- Glucose Metabolism Disorders · Phase 1/Phase 2
- Graft vs Host Disease · Phase 3
- Granulomatous Disease, Chronic · Phase 1/Phase 2
- Hamartoma · Phase 2
- Head and Neck Neoplasms · Phase 2
- Hematologic Diseases · Phase 2
- Hematologic Neoplasms · Phase 1
- Hematopoietic Stem Cell Transplantation · Phase 2
- Hemoglobinuria, Paroxysmal · Phase 2
- HIV Infections · Phase 2
- Hodgkin Disease · Phase 3
- Immune System Diseases · Phase 1/Phase 2
- Infections · Phase 2
- Infertility, Male · Phase 1/Phase 2
- Inflammatory Breast Neoplasms · Phase 2
- Intestinal Neoplasms · Phase 2
- Intraocular Lymphoma · Phase 2
- Ischemic Stroke · Phase 2
- Kidney Neoplasms · Phase 2
- Lambert-Eaton Myasthenic Syndrome · Phase 2
- Leukemia · Phase 3
- Leukemia, Biphenotypic, Acute · Phase 2
- Leukemia, Eosinophilic, Acute · Phase 3
- Leukemia, Hairy Cell · Phase 2
- Leukemia, Large Granular Lymphocytic · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 3
- Leukemia, Lymphoid · Phase 2/Phase 3
- Leukemia-Lymphoma, Adult T-Cell · Phase 2
- Leukemia, Mast-Cell · Phase 2
- Leukemia, Monocytic, Acute · Phase 3
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 3
- Leukemia, Myeloid · Phase 3
- Leukemia, Myeloid, Acute · Phase 4
- Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative · Phase 2
- Leukemia, Myeloid, Chronic-Phase · Phase 2
- Leukemia, Myelomonocytic, Acute · Phase 3
- Leukemia, Myelomonocytic, Chronic · Phase 2
- Leukemia, Myelomonocytic, Juvenile · Phase 2
- Leukemia, Neutrophilic, Chronic · Phase 2
- Leukemia, Plasma Cell · Phase 2
- Leukemia, Prolymphocytic · Phase 3
- Leukemia, Prolymphocytic, B-Cell · Phase 2
- Leukemia, Prolymphocytic, T-Cell · Phase 3
- Liver Neoplasms · Phase 1
- Lung Neoplasms · Phase 3
- Lupus Erythematosus, Systemic · Phase 2/Phase 3
- Lymphoma · Phase 3
- Lymphoma, AIDS-Related · Phase 1
- Lymphoma, B-Cell · Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 2
- Lymphoma, Follicular · Phase 3
- Lymphoma, Large B-Cell, Diffuse · Phase 3
- Lymphoma, Large-Cell, Anaplastic · Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 3
- Lymphoma, Mantle-Cell · Phase 3
- Lymphoma, Non-Hodgkin · Phase 3
- Lymphoma, Primary Cutaneous Anaplastic Large Cell · Phase 2
- Lymphoma, T-Cell · Phase 2
- Lymphoma, T-Cell, Peripheral · Phase 2
- Lymphomatoid Granulomatosis · Phase 2
- Lymphoproliferative Disorders · Phase 2
- Mastocytosis · Phase 2
- Mediastinal Neoplasms · Phase 3
- Medulloblastoma · Phase 3
- Melanoma · Phase 2
- Meningitis · Phase 1/Phase 2
- Metabolic Diseases · Phase 1/Phase 2
- Multiple Myeloma · Phase 3
- Multiple Sclerosis · Phase 2
- Multiple Sclerosis, Relapsing-Remitting · Phase 2
- Myasthenia Gravis · Phase 2
- Myelodysplastic-Myeloproliferative Diseases · Phase 3
- Myelodysplastic Syndromes · Phase 4
- Myeloproliferative Disorders · Phase 3
- Myocardial Infarction · Phase 3
- Neoplasm Metastasis · Phase 2/Phase 3
- Neoplasm, Residual · Phase 2
- Neoplasms · Phase 3
- Neoplasms, Germ Cell and Embryonal · Phase 3
- Neuroblastoma · Phase 3
- Neuroectodermal Tumors · Phase 3
- Neuromyelitis Optica · Phase 2
- Neutropenia · Phase 3
- Opsoclonus-Myoclonus Syndrome · Phase 2
- Organ Transplantation · Phase 2
- Osteoarthritis, Hip · Phase 1
- Osteoarthritis, Knee · Phase 1
- Ovarian Neoplasms · Phase 3
- Pancreatic Neoplasms · Phase 1/Phase 2
- Pemphigus · Phase 1
- Peripheral Vascular Diseases · Phase 1
- Plasmablastic Lymphoma · Phase 1/Phase 2
- Plasmacytoma · Phase 2
- Polycythemia Vera · Phase 2
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating · Phase 2
- Precancerous Conditions · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 3
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 3
- Primary Myelofibrosis · Phase 3
- Prognosis · Phase 2
- Prostatic Neoplasms · Phase 2
- Retinitis Pigmentosa · Phase 1/Phase 2
- Retinoblastoma · Phase 3
- Rhabdoid Tumor · Phase 3
- Rhabdomyosarcoma · Phase 2
- Sarcoidosis · Phase 1/Phase 2
- Sarcoma · Phase 3
- Sarcoma, Ewing · Phase 2
- Sarcoma, Myeloid · Phase 2
- Scleroderma, Systemic · Phase 3
- Severe Combined Immunodeficiency · Phase 2
- Sezary Syndrome · Phase 2
- Shwachman-Diamond Syndrome · Phase 2
- Smoldering Multiple Myeloma · Phase 3
- Spinal Cord Injuries · Phase 1/Phase 2
- Stem Cell Transplantation · Phase 2
- Stiff-Person Syndrome · Phase 2
- Stroke · Phase 2
- Teratoma · Phase 2
- Testicular Neoplasms · Phase 3
- Thrombocythemia, Essential · Phase 2
- Thrombocytopenia · Phase 2
- Tissue Donors · Phase 2
- Translocation, Genetic · Phase 2
- Transplantation · Phase 2
- Transplantation, Autologous · Phase 2
- Transplantation, Homologous · Phase 2
- Transplants · Phase 2
- Urinary Bladder Neoplasms · Phase 2
- Uterine Cervical Neoplasms · Phase 2
- Vaginal Neoplasms · Phase 2
- Vasculitis, Central Nervous System · Phase 2
- Waldenstrom Macroglobulinemia · Phase 3
- Wiskott-Aldrich Syndrome · Phase 2
Mechanism of action
- Stem CellSupplementation
Stem Cell supplementation
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaPeripheral stem cell transplantation ↗
- WikipediaBlood cell ↗
Also known as
- autologous hct
- autologous hematopoietic cell
- autologous hematopoietic cells
- autologous hematopoietic stem cell
- autologous hematopoietic stem cells
- hct
- hematopoietic cell
- peripheral blood derived stem cell
- peripheral blood hematopoietic cell
- peripheral blood stem cell
- peripheral blood stem cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07046078 | Phase 2 | Sep 26, 2025 | University of Washington |
| NCT07127289 | Phase 2 | Aug 31, 2025 | China Academy of Chinese Medical Sciences |
| NCT07034755 | N/A | Jul 1, 2025 | Xuzhou Medical University |
| NCT06514898 | Phase 1 | Dec 31, 2024 | Georgetown University, University of Florida |
| NCT06752720 | Phase 2 | Dec 1, 2024 | Hokkaido University |
| NCT06589089 | Phase 2 | Oct 15, 2024 | Jiao Tong University |
| NCT06254326 | Phase 1 | Sep 19, 2024 | University of Florida |
| NCT06608342 | Phase 2 | Jun 25, 2024 | China Academy of Chinese Medical Sciences, Juventas Therapeutics, Inc. |
| NCT06655662 | Phase 1 | Jun 12, 2024 | Hacettepe University, Henogen, Shenzhen University |
| NCT06364150 | Phase 3 | May 1, 2024 | Seoul National University |
| NCT05887167 | Phase 1 | Dec 1, 2023 | Cedars-Sinai Medical Center |
| NCT05482542 | N/A | Jan 1, 2023 | Scripps |
| NCT05442346 | N/A | Dec 25, 2022 | Hacettepe University, Shanghai Bioray Laboratory Inc. |
| NCT05851105 | Early Phase 1 (Phase 1) | Oct 8, 2022 | Henogen |
| NCT05463133 | Phase 1/Phase 2 (Phase 2) | Jul 8, 2022 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT05864170 | Early Phase 1 (Phase 1) | May 27, 2022 | Henogen, Shenzhen University |
| NCT05239676 | Early Phase 1 (Phase 1) | Feb 28, 2022 | Yake Biotechnology Ltd., Zhejiang University |
| NCT04971005 | Phase 2 | Aug 27, 2021 | CTC Bio, Inc., Neovii Biotech, University of Hamburg |
| NCT05745532 | Early Phase 1 (Phase 1) | Dec 1, 2020 | Henogen, Shenzhen University |
| NCT04205435 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2020 | Central South University, Shanghai Bioray Laboratory Inc. |
Showing 20 of 618 trials
Page 1 / 31
Organizations
Research & Development (289)
289 organizations
Page 1 / 15