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Leukemia, Neutrophilic, Chronic

A rare myeloproliferative disorder that is characterized by a sustained, mature neutrophilic leukocytosis. No monocytosis, EOSINOPHILIA, or basophilia is present, nor is there a PHILADELPHIA CHROMOSOME or bcr-abl fusion gene (GENES, ABL).

Drugs by status

Phase 3 trials (1)

  • calcium phosphate

Phase 2 trials (17)

  • azacitidine
  • venetoclax
  • busulfan
  • tacrolimus
  • naltrexone
  • beclomethasone
  • pevonedistat
  • allogeneic hematopoietic stem cells
  • ruxolitinib
  • fedratinib
  • mycophenolate
  • cyclophosphamide
  • beractant
  • allogeneic lymphocytes
  • ondansetron
  • fludarabine
  • autologous hematopoietic stem cells

Phase 1 trials (9)

  • decitabine
  • imatinib
  • msk-2206
  • sunitinib
  • vorinostat
  • etoposide
  • cefepime
  • cytarabine
  • momelotinib

Other trials (10)

  • deferasirox
  • foscarnet
  • ganciclovir
  • palifermin
  • lithium
  • cyclosporine
  • Anti-thymocyte Globulin (Rabbit)
  • valganciclovir
  • melphalan
  • interferon alpha-2b

Organizations

Organization Involved with Phase 3 Indications (1)

  • National Cancer Institute (NCI)

Organization Involved with Phase 2 Indications (4)

  • University of Washington
  • Oregon Health and Science University
  • Thomas Jefferson University
  • University of Texas at Houston

Organization Involved with Phase 1 Indications (4)

  • University of Pittsburgh
  • AIDS Malignancy Consortium
  • University of Maryland
  • Wake Forest University

Organization Involved with Other Experimental Indications (2)

  • City of Hope National Medical Center
  • State University of New York, Buffalo

ICD-10 crosswalk

  • D47.1 — Chronic myeloproliferative disease

CDEK

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