xl999
Small moleculeexperimental
Clinical trial activity
10 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
6
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2004 (NCT00104117)
Timeline
Indications
Mechanism of action
Platelet-derived growth factor receptor inhibitor
Spectrum Selective Kinase Inhibitor (SSKI)
- Fibroblast growth factor receptorINHIBITOR
Fibroblast growth factor receptor inhibitor
Spectrum Selective Kinase Inhibitor (SSKI)
Vascular endothelial growth factor receptor inhibitor
Spectrum Selective Kinase Inhibitor (SSKI)
FLT3 inhibitor
Spectrum Selective Kinase Inhibitor (SSKI)
- Stem cell growth factor receptorINHIBITOR
KIT inhibitor
Spectrum Selective Kinase Inhibitor (SSKI)
Chemistry & pharmacology
Loading structure…
SMILES
CCN1CCC(Nc2ccc3c(c2)/C(=C(\c2cccc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1- Mol. weight
- 445.54 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5314391 ↗
- ChEMBLCHEMBL3545285 ↗
Also known as
- xl999
- xl999
- xl-999
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01945164 | N/A | Apr 1, 2010 | University of Texas, San Antonio |
| NCT00955084 | Phase 1 | Aug 1, 2008 | Symphony Capital |
| NCT00491699 | Phase 1 | Aug 1, 2007 | Exelixis, Symphony Capital |
| NCT00322673 | Phase 2 | May 1, 2006 | Exelixis, Symphony Capital |
| NCT00304590 | Phase 2 | Feb 1, 2006 | Exelixis, Symphony Capital |
| NCT00277290 | Phase 2 | Jan 1, 2006 | Exelixis, Symphony Capital |
| NCT00277329 | Phase 2 | Dec 1, 2005 | Exelixis, Symphony Capital |
| NCT00277316 | Phase 2 | Dec 1, 2005 | Exelixis, Symphony Capital |
| NCT00277303 | Phase 2 | Dec 1, 2005 | Exelixis, Symphony Capital |
| NCT00104117 | Phase 1 | Nov 1, 2004 | Exelixis, Symphony Capital |
Showing 10 of 10 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Symphony Capital | For profit | 9 | 9 | 2 | 2004 |
| Exelixis | For profit | 8 | 0 | 2 | 2004 |
| University of Texas, San Antonio | Academic/Hospital | 1 | 1 | 1 | 2010 |
3 organizations
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