CDEK
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vatalanib

Small moleculeexperimental

Vatalanib is a small molecule protein kinase inhibitor that inhibits angiogenesis. It is being studied as a possible treatment for several types of cancer, particularly cancer that is at an advanced stage or has not responded to chemotherapy. Vatalanib is orally active, which is to say it is effective when taken by mouth. — Wikipedia

Clinical trial activity

46 trials · 38 clinical orgs · 0 marketing orgs

Phase 1
21
Phase 2
33
Phase 3
2
Phase 4
0

Earliest trial started Oct 11, 2001 (NCT00025051)

Timeline

2000s

  1. Jan 1, 2001

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2002

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Mol. weight
346.82 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate
  • 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate
  • 1-(4-chloroanilino)-4-(pyridylmethyl)phthalazine
  • 1-(4-chloroanilino)-(4-pyridylmethyl)phthalazine dihydrochloride
  • 1-(4-chloroanilino)-4-(pyridylmethyl)phthalazine dihydrochloride
  • bay-86-5127
  • bay-86-5127
  • cgp-79787
  • cgp-79787
  • cgp 797870
  • cgp-797870
  • k-222584
  • k-222584
  • nvp-ptk787
  • nvp-ptk787
  • ptk787
  • ptk787
  • ptk787
  • ptk787
  • ptk 787
  • ptk 787
  • ptk 787
  • ptk-787
  • ptk-787
  • ptk-787
  • ptk/zk
  • ptk/zk
  • vatalanib
  • vatalanib
  • vatalanib
  • vatalanib
  • vatalanib
  • vatalinib
  • vatalinib
  • zk222584
  • zk222584
  • zk222584
  • zk 222584
  • zk-222584
  • zk-222584
  • zk-222584
  • zk232934
  • zk 232934
  • zk-232934

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01105364N/ADec 1, 2007François Rabelais University, National Cancer Institute, France
NCT00390000Phase 1Jan 1, 2007Mayo Clinic, National Cancer Institute (NCI)
NCT00627198Phase 2Dec 1, 2006Novartis, University of Iowa
NCT00615160Phase 1/Phase 2 (Phase 2)Dec 1, 2006Universitaetsklinikum Schleswig-Holstein
NCT00390364Phase 2Oct 1, 2006Johns Hopkins University, National Cancer Institute (NCI)
NCT00385853Phase 1Sep 1, 2006Harvard University, Novartis
NCT00426452Phase 1Jul 1, 2006Bayer, Novartis
NCT00348790Phase 2May 1, 2006Northwestern University, Novartis
NCT00358163Phase 1Apr 1, 2006Harvard University, Novartis
NCT00263198Phase 2Mar 1, 2006Novartis, Washington University in St. Louis
NCT00563823Phase 2Feb 1, 2006University of Cambridge
NCT00281125Phase 1/Phase 2 (Phase 2)Jan 1, 2006Nevada Cancer Institute
NCT00226005Phase 2Dec 1, 2005Pancreatic Cancer Research Team, University of Arizona
NCT00253526Phase 2Nov 11, 2005National Cancer Institute (NCI)
NCT00511043Phase 2Nov 1, 2005Duke University, Novartis
NCT00227773Phase 2Sep 26, 2005Eastern Cooperative Oncology Group, National Cancer Institute (NCI), Northwestern University, University of Wisconsin
NCT00268918Phase 1Sep 1, 2005Harvard University
NCT00138632Phase 1/Phase 2 (Phase 2)Sep 1, 2005Novartis
NCT00240162Phase 2Sep 1, 2005Washington University in St. Louis
NCT00134355Phase 2Jul 1, 2005Novartis, University of Michigan
Showing 20 of 46 trials
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Organizations

Research & Development (38)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
NovartisFor profit22632002
National Cancer Institute (NCI)Government13422001
BayerFor profit6132002
Harvard UniversityAcademic/Hospital4422003
Duke UniversityAcademic/Hospital3322004
Indiana UniversityAcademic/Hospital2122005
Mayo ClinicAcademic/Hospital2212004
Northwestern UniversityAcademic/Hospital2112005
SCRI Development InnovationsFor profit2212004
University of California, San FranciscoAcademic/Hospital2112003
Washington University in St. LouisAcademic/Hospital2212005
Department of Veteran AffairsGovernment1012003
Eastern Cooperative Oncology GroupAcademic/Hospital1112005
European Organisation for Research and Treatment of CancerAcademic/Hospital1112005
François Rabelais UniversityAcademic/Hospital1012007
Harper HospitalAcademic/Hospital1012002
Harrington Cancer CenterAcademic/Hospital1012003
Herbert Irving Comprehensive Cancer CenterAcademic/Hospital1012001
Hoosier Cancer Research NetworkAcademic/Hospital1112005
Johns Hopkins UniversityAcademic/Hospital1112006
38 organizations
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