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metoprolol

Trade name: lopressor

Small moleculeapproved

Approved

Aug 7, 1978

Mrtoprolol is a beta-adrenergic receptor blocking agent. In vitro and in vivo animal studies have shown that it has a preferential effect on beta-1 adrenoreceptors, chiefly located in cardiac muscle. Clinical pharmacology studies have confirmed the beta-blocking activity of metoprolol in man, as shown by (1) reduction in heart rate and cardiac output at rest and upon exercise, (2) reduction of systolic blood pressure upon exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia. Mrtoprolol is indicated for the treatment of hypertension, angina pectoris and myocardial infarction — NCATS

Clinical trial activity

236 trials · 242 clinical orgs · 58 marketing orgs

Phase 1
47
Phase 2
56
Phase 3
43
Phase 4
90

Earliest trial started Sep 1, 1980 (NCT00000499)

Timeline

1970s

  1. Aug 7, 1978

    Earliest FDA Approval

  2. Aug 7, 1978

    Validus Pharmaceuticals — NDA Secondary Org

1980s

  1. Jan 1, 1980

    Earliest Phase 2 Sponsor(trial)

  2. Mar 30, 1984

    Novartis — NDA Secondary Org

1990s

  1. Jan 10, 1992

    Aralez Pharmaceuticals — NDA Secondary Org

  2. Jan 10, 1992

    AstraZeneca — Marketing Organization

  3. Jan 10, 1992

    AstraZeneca — NDA Secondary Org

  4. Dec 21, 1993

    Hospira — Marketing Organization

  5. Dec 21, 1993

    Mylan — Marketing Organization

  6. Dec 21, 1993

    Watson Pharmaceuticals — Marketing Organization

  7. Dec 21, 1993

    Mutual Pharmaceutical — Marketing Organization

  8. Dec 21, 1993

    PHARMOBEDIENT — Marketing Organization

  9. Jan 27, 1994

    Apothecon — Marketing Organization

  10. Jan 27, 1994

    Teva — Marketing Organization

  11. Mar 25, 1994

    Fosun — Marketing Organization

  12. Mar 25, 1994

    Chartwell Pharmaceuticals — Marketing Organization

  13. Jan 1, 1995

    Earliest Phase 3 Sponsor(trial)

  14. Jan 31, 1995

    Heritage Pharma — Marketing Organization

  15. Apr 27, 1995

    Renata — Marketing Organization

2000s

  1. Jan 1, 2000

    AstraZeneca — Earliest Phase 1 Sponsor(trial)

  2. Jul 7, 2003

    Hikma — Marketing Organization

  3. Jul 7, 2003

    West-Ward Pharmaceutical — Marketing Organization

  4. Jul 31, 2006

    Sandoz — Marketing Organization

  5. Jul 31, 2006

    Novartis — Marketing Organization

  6. Aug 28, 2006

    Advanz Pharma — Marketing Organization

  7. Aug 28, 2006

    Advanz Pharma — NDA Secondary Org

  8. May 18, 2007

    Nesher Pharms — Marketing Organization

  9. Sep 11, 2007

    Aurobindo Pharma — Marketing Organization

  10. Jun 17, 2008

    IPCA Laboratories Ltd. — Marketing Organization

  11. Sep 30, 2009

    Lutipold — Marketing Organization

  12. Sep 30, 2009

    Sankyo — Marketing Organization

  13. Sep 30, 2009

    Daiichi Sankyo — Marketing Organization

2010s

  1. Apr 19, 2010

    STERISCIENCE — Marketing Organization

  2. Apr 19, 2010

    ONESOURCE SPECIALTY — Marketing Organization

  3. Jul 22, 2010

    Wockhardt — Marketing Organization

  4. Oct 25, 2010

    Fresenius — Marketing Organization

  5. Jan 19, 2012

    Sun Pharmaceuticals — Marketing Organization

  6. Aug 15, 2012

    Dr. Reddy's Laboratories — Marketing Organization

  7. Apr 29, 2013

    Baxalta — Marketing Organization

  8. May 28, 2013

    Alembic — Marketing Organization

  9. Aug 27, 2014

    Gland Pharma Ltd — Marketing Organization

  10. Oct 28, 2014

    Rubicon Research — Marketing Organization

  11. Nov 25, 2016

    Actavis — Marketing Organization

  12. Nov 25, 2016

    Allergan PLC (2015) — Marketing Organization

  13. Jan 26, 2018

    Sun Pharmaceuticals — NDA Secondary Org

  14. Feb 6, 2018

    Novast Labs — Marketing Organization

  15. Mar 23, 2018

    Zydus Discovery DMCC — Marketing Organization

  16. Oct 26, 2018

    Cipla — Marketing Organization

  17. Dec 19, 2018

    TWi Biotechnology, Inc. — Marketing Organization

  18. Dec 19, 2018

    Suzhou Kintor Pharmaceutical Inc, — Marketing Organization

2020s

  1. Feb 5, 2020

    Youngtech Pharmaceuticals — Marketing Organization

  2. Feb 5, 2020

    Sciegen Pharmaceticals — Marketing Organization

  3. Mar 30, 2020

    Pharmadax Inc — Marketing Organization

  4. Nov 6, 2020

    Hetero Labs Ltd — Marketing Organization

  5. Nov 25, 2020

    Alkem Labs Ltd — Marketing Organization

  6. Feb 12, 2021

    Yichang Humanwell Pharmaceutical Co.,Ltd — Marketing Organization

  7. Jan 4, 2022

    Prinston Inc — Marketing Organization

  8. Sep 26, 2022

    Sunshine Lake Pharma Co., Ltd. — Marketing Organization

  9. Oct 18, 2022

    Accord Research — Marketing Organization

  10. Jun 12, 2023

    Granules India — Marketing Organization

  11. Aug 15, 2023

    Lupin — Marketing Organization

  12. Jul 26, 2024

    Zhejiang Jutai Pharm — Marketing Organization

  13. Jan 8, 2025

    Senores Pharms — Marketing Organization

  14. Aug 28, 2025

    XTM CONSULTING — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedPriority reviewAug 7, 1978

Chemistry & pharmacology

Loading structure…

SMILES

COCCC1=CC=C(OCC(O)CNC(C)C)C=C1
Mol. weight
267.3639 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Availability
Prescription Only

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
  • 1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
  • arbralene
  • arbralene
  • beatrolol
  • beloc cor
  • betaloc
  • betaloc
  • betaloc
  • betaloc s.a.
  • cgp-2175c
  • cgp-2175c
  • cgp-2175e
  • cgp-2175e
  • dl-metoprolol
  • dl-metoprolol
  • h-93/26
  • h-93/26
  • h 93/26 succinate
  • h 93/26 succinate
  • lopresor
  • lopresor
  • lopresor sr
  • lopressidone
  • lopressidone
  • lopressor
  • lopressor
  • lopressor
  • lopressor
  • mepranix 100
  • mepranix 50
  • metopolol
  • metoprolol
  • metoprolol
  • metoprolol
  • metoprolol
  • metoprolol
  • metoprolol
  • metoprolol
  • metoprolol
  • metoprolol fumarate
  • metoprolol fumarate
  • metoprolol fumarate
  • metoprolol fumarate
  • metoprolol fumarate
  • metoprolol fumarate
  • metoprolol fumarate
  • metoprolol succinate
  • metoprolol succinate
  • metoprolol succinate
  • metoprolol succinate
  • metoprolol succinate
  • metoprolol tartrate
  • metoprolol tartrate
  • metoprolol tartrate
  • metoprolol tartrate
  • metoprolol tartrate
  • metoros
  • metoros ls
  • (rs)-metoprolol
  • (rs)-metoprolol
  • tensomex
  • toprol
  • toprol
  • toprol
  • toprol xl
  • toprol xl
  • toprol-xl
  • toprol-xl

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07103655Phase 4Jan 1, 2026Zhejiang University
NCT07268170Phase 2/Phase 3 (Phase 3)Dec 15, 2025Gødstrup Hospital
NCT06964464Phase 4Aug 17, 2025Patient-Centered Outcomes Research Institute, University of Rochester
NCT06864234Phase 4Jul 3, 2025VZW Cardiovascular Research Center Aalst
NCT06967194N/AMay 21, 2025Tel Aviv University
NCT06825728Phase 4Feb 28, 2025Central South University
NCT06808802Phase 1Feb 28, 2025Eli Lilly
NCT06686628Phase 1Nov 13, 2024Sanofi
NCT06569212Phase 4Sep 30, 2024MaineGeneral Health
NCT05931276Phase 3Jan 1, 2024Department of Veteran Affairs
NCT05847517Phase 3Nov 30, 2023Consorcio Centro de Investigación Biomédica en Red, M.P., European Commission, Universidad Carlos III Madrid
NCT06035978Phase 4Nov 30, 2023University of Ostrava
NCT06853951Phase 3Jul 18, 2023Ain Shams University
NCT05767346Phase 3Jun 19, 2023Cytokinetics
NCT05891119Early Phase 1 (Phase 1)Jun 3, 2023Amgen
NCT05741385N/AApr 25, 2023Boehringer Ingelheim
NCT05711810Phase 4Jan 2, 2023University of Pennsylvania
NCT05631730Phase 3Dec 31, 2022Government of Norway, University of Oslo
NCT05546320Phase 4Oct 15, 2022Chinese Academy of Medical Sciences
NCT06592547Phase 2Apr 1, 2022Alexandria University
Showing 20 of 236 trials
Page 1 / 12

Organizations

Research & Development (242)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
AstraZenecaFor profit201151999
Forest LaboratoriesFor profit17332007
Boehringer IngelheimFor profit6442003
Capital Medical UniversityAcademic/Hospital6342013
GlaxoSmithKlineFor profit6422000
MylanFor profit6522002
National Heart, Lung, and Blood Institute (NHLBI)Government6241980
SanionaFor profit6622016
Vanderbilt UniversityAcademic/Hospital6532001
SanofiFor profit5321999
University of CopenhagenAcademic/Hospital5312004
Kuopio University HospitalAcademic/Hospital4432007
People's Liberation Army of ChinaGovernment4332005
University of Alabama, BirminghamAcademic/Hospital4231980
University of OsloAcademic/Hospital4332006
China Academy of Chinese Medical SciencesAcademic/Hospital3312017
Cliantha Research LimitedFor profit3012013
Creighton UniversityAcademic/Hospital3322005
Danish Heart FoundationAcademic/Hospital3012004
Eli LillyFor profit3322009
242 organizations
Page 1 / 13

Marketing (77)

OrganizationOrg typeRelationshipDate
Accord ResearchFor profitMKTGOct 18, 2022
ActavisFor profitMKTGNov 25, 2016
ActavisFor profitSYNAug 3, 2009
Advanz PharmaFor profitMKTGAug 28, 2006
Advanz PharmaFor profitNDA2Aug 28, 2006
AlembicFor profitMKTGMay 28, 2013
AlembicFor profitSYNNov 6, 2013
Alkem Labs LtdFor profitMKTGNov 25, 2020
Allergan PLC (2015)For profitMKTGNov 25, 2016
ApotheconFor profitMKTGJan 27, 1994
Aralez PharmaceuticalsFor profitNDA2Jan 10, 1992
AstraZenecaFor profitMKTGJan 10, 1992
AstraZenecaFor profitNDA2Jan 10, 1992
Aurobindo PharmaFor profitMKTGSep 11, 2007
BaxaltaFor profitMKTGApr 29, 2013
Chartwell PharmaceuticalsFor profitMKTGMar 25, 1994
Ciba-GeigyFor profitNDA—
CiplaFor profitMKTGOct 26, 2018
Daiichi SankyoFor profitMKTGSep 30, 2009
Dr. Reddy's LaboratoriesFor profitSYNAug 1, 2012
Dr. Reddy's LaboratoriesFor profitMKTGAug 15, 2012
FosunFor profitMKTGMar 25, 1994
FreseniusFor profitMKTGOct 25, 2010
Gland Pharma LtdFor profitMKTGAug 27, 2014
Gland Pharma LtdFor profitSYNAug 27, 2014
Granules IndiaFor profitMKTGJun 12, 2023
Heritage PharmaFor profitMKTGJan 31, 1995
Hetero Labs LtdFor profitMKTGNov 6, 2020
HikmaFor profitMKTGMay 30, 2007
HikmaFor profitMKTGJul 7, 2003
HikmaFor profitSYNJul 7, 2003
HospiraFor profitMKTGDec 21, 1993
IPCA Laboratories Ltd.For profitMKTGJun 17, 2008
LupinFor profitMKTGAug 15, 2023
LutipoldFor profitMKTGSep 30, 2009
Mutual PharmaceuticalFor profitMKTGDec 21, 1993
MylanFor profitMKTGDec 21, 1993
MylanFor profitSYNApr 19, 2010
MylanFor profitSYNDec 15, 2011
Nesher PharmsFor profitMKTGMay 18, 2007
NovartisFor profitNDA2Mar 30, 1984
NovartisFor profitMKTGJul 31, 2006
Novast LabsFor profitMKTGFeb 6, 2018
ONESOURCE SPECIALTYFor profitMKTGApr 19, 2010
PHARMOBEDIENTFor profitMKTGDec 21, 1993
Pharmadax IncFor profitMKTGMar 30, 2020
Prinston IncFor profitMKTGJan 4, 2022
Puracap PharmaceuticalFor profitMKTG—
RenataFor profitMKTGApr 27, 1995
Rubicon ResearchFor profitMKTGOct 28, 2014
Rubicon ResearchFor profitSYNOct 28, 2014
STERISCIENCEFor profitMKTGApr 19, 2010
SandozFor profitMKTGJul 31, 2006
SandozFor profitSYNOct 2, 2007
SankyoFor profitMKTGSep 30, 2009
Sciegen PharmaceticalsFor profitMKTGFeb 5, 2020
Senores PharmsFor profitMKTGJan 8, 2025
Sun PharmaceuticalsFor profitNDA2Jan 26, 2018
Sun PharmaceuticalsFor profitMKTGJan 19, 2012
Sun PharmaceuticalsFor profitSYNDec 10, 1996
Sun PharmaceuticalsFor profitSYNDec 21, 1993
Sunshine Lake Pharma Co., Ltd.For profitMKTGSep 26, 2022
Suzhou Kintor Pharmaceutical Inc,For profitMKTGDec 19, 2018
TWi Biotechnology, Inc.For profitMKTGDec 19, 2018
TevaFor profitSYNSep 30, 1994
TevaFor profitMKTGJan 27, 1994
Validus PharmaceuticalsFor profitSYNAug 7, 1978
Validus PharmaceuticalsFor profitNDA2Aug 7, 1978
Watson PharmaceuticalsFor profitMKTGDec 21, 1993
West-Ward PharmaceuticalFor profitMKTGJul 7, 2003
WockhardtFor profitMKTGJul 22, 2010
WockhardtFor profitSYNJul 22, 2010
XTM CONSULTINGFor profitMKTGAug 28, 2025
Yichang Humanwell Pharmaceutical Co.,LtdFor profitMKTGFeb 12, 2021
Youngtech PharmaceuticalsFor profitMKTGFeb 5, 2020
Zhejiang Jutai PharmFor profitMKTGJul 26, 2024
Zydus Discovery DMCCFor profitMKTGMar 23, 2018