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hydrochlorothiazide

Trade name: esidrix

Small moleculeapproved

Approved

Feb 12, 1959

CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) for oral administration combines two antihypertensive agents: captopril and hydrochlorothiazide. The mechanism of action of captopril has not yet been fully elucidated. Captopril prevents the conversion of angiotensin I to angiotensin II by inhibition of ACE, a peptidyldipeptide carboxy hydrolase. Hydrochlorothiazide belongs to thiazide class of diuretics. It reduces blood volume by acting on the kidneys to reduce sodium (Na+) reabsorption in the distal convoluted tubule. CAPOZIDE (captopril and hydrochlorothiazide tablets, USP) is indicated for the treatment of hypertension. The blood pressure lowering effects of captopril and thiazides are approximately additive. Major side effects are: Black, tarry stools; chest pain; chills; cough; fever; painful or difficult urination; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; unusual bleeding or bruising; unusual tiredness or weakness. It has been reported that indomethacin may reduce the antihypertensive effect of captopril, especially in cases of low renin hypertension. Captopril’s effect will be augmented by antihypertensive agents that cause renin release. For example, diuretics (e.g., thiazides) may activate the renin-angiotensin-aldosterone system. — NCATS

Clinical trial activity

433 trials · 313 clinical orgs · 113 marketing orgs

Phase 1
94
Phase 2
141
Phase 3
118
Phase 4
147

Earliest trial started Jul 1, 1986 (NCT00000525)

Timeline

1950s

  1. Feb 12, 1959

    Ciba — Earliest FDA Approval

  2. Feb 12, 1959

    Novartis — NDA Secondary Org

  3. Feb 12, 1959

    Ciba — NDA Organization

  4. Feb 24, 1959

    Merck — NDA Secondary Org

  5. Jul 6, 1959

    AbbVie — NDA Secondary Org

1960s

  1. Jan 27, 1961

    G D Searle — Marketing Organization

  2. Jan 27, 1961

    Pfizer — NDA Secondary Org

  3. Dec 2, 1965

    GlaxoSmithKline — Marketing Organization

  4. Dec 2, 1965

    GlaxoSmithKline — NDA Secondary Org

1970s

  1. Jul 2, 1974

    Whiteworth Towne Paulsen — Marketing Organization

  2. Jan 24, 1975

    Teva — Marketing Organization

  3. May 30, 1975

    Barr Laboratories — Marketing Organization

  4. May 26, 1976

    Novartis — Marketing Organization

  5. Sep 21, 1976

    Inwood Laboratories — Marketing Organization

  6. Dec 17, 1976

    Fosun — Marketing Organization

  7. Jan 7, 1977

    Watson Pharmaceuticals — Marketing Organization

  8. Jan 31, 1977

    Hikma — Marketing Organization

  9. Mar 10, 1977

    Lannett Company, Inc. — Marketing Organization

  10. Mar 21, 1977

    Chartwell Pharmaceuticals — Marketing Organization

  11. May 3, 1977

    Solvay — Marketing Organization

  12. Jun 2, 1977

    AmerisourceBergen — Marketing Organization

  13. Aug 19, 1977

    Impax Laboratories — Marketing Organization

  14. Jul 13, 1978

    Roxane Laboratories — Marketing Organization

  15. Oct 11, 1978

    Mylan — Marketing Organization

  16. Jun 15, 1979

    Wyeth — Marketing Organization

  17. Jun 15, 1979

    American Home Products — NDA Secondary Org

1980s

  1. May 7, 1980

    Ivax — Marketing Organization

  2. Nov 5, 1980

    DAVA Pharmaceuticals — Marketing Organization

  3. Nov 5, 1980

    Oxford Pharmaceuticals — Marketing Organization

  4. Apr 16, 1981

    Mutual Pharmaceutical — Marketing Organization

  5. Apr 16, 1981

    Sandoz — Marketing Organization

  6. Aug 20, 1981

    Actavis — Marketing Organization

  7. Dec 7, 1981

    Vanguard — Marketing Organization

  8. Jul 21, 1982

    Alta Pharma — Marketing Organization

  9. Mar 30, 1983

    Lederle — Marketing Organization

  10. Mar 30, 1983

    American Cyanamid — Marketing Organization

  11. May 10, 1984

    West-Ward Pharmaceutical — Marketing Organization

  12. Oct 12, 1984

    Apothecon — Marketing Organization

  13. Oct 12, 1984

    Apothecon — NDA Secondary Org

  14. Oct 22, 1984

    Aurobindo Pharma — NDA Secondary Org

  15. Dec 28, 1984

    Superpharm — Marketing Organization

  16. Dec 31, 1984

    Validus Pharmaceuticals — Marketing Organization

  17. Dec 31, 1984

    Validus Pharmaceuticals — NDA Secondary Org

  18. Jul 3, 1985

    American Home Products — Marketing Organization

  19. Oct 21, 1985

    Par Pharmaceuticals — Marketing Organization

  20. Oct 21, 1985

    Strides Pharma Science — Marketing Organization

  21. Nov 6, 1985

    Puracap Pharmaceutical — Marketing Organization

  22. Jan 1, 1986

    Earliest Phase 3 Sponsor(trial)

  23. Jan 23, 1986

    Rising Pharmaceuticals — Marketing Organization

  24. Oct 1, 1986

    Ani Pharmaceuticals — Marketing Organization

  25. Oct 1, 1986

    Ani Pharmaceuticals — NDA Secondary Org

  26. Oct 31, 1986

    Bausch Health Companies — Marketing Organization

  27. Oct 31, 1986

    Bausch Health Companies — NDA Secondary Org

  28. Mar 2, 1987

    Duramed Research — Marketing Organization

  29. Apr 6, 1987

    Schering — Marketing Organization

  30. Apr 6, 1987

    Schering-Plough — NDA Secondary Org

  31. Jan 26, 1988

    Warner Chilcott — Marketing Organization

  32. Jul 20, 1989

    Alvogen — Marketing Organization

  33. Jul 20, 1989

    Alvogen — NDA Secondary Org

1990s

  1. Jul 31, 1991

    CASI Pharmaceuticals, Inc. — Marketing Organization

  2. Mar 26, 1993

    Teva — NDA Secondary Org

  3. Nov 30, 1994

    Bristol-Myers Squibb — Marketing Organization

  4. Nov 30, 1994

    Bristol-Myers Squibb — NDA Secondary Org

  5. Apr 28, 1995

    Organon — NDA Secondary Org

  6. Apr 28, 1995

    Merck — Marketing Organization

  7. Apr 26, 1996

    Pliva — Marketing Organization

  8. Dec 27, 1996

    Allergan — Marketing Organization

  9. Dec 27, 1996

    Allergan — NDA Secondary Org

  10. Jun 27, 1997

    UCB — Marketing Organization

  11. Jun 27, 1997

    UCB — NDA Secondary Org

  12. Sep 30, 1997

    Sanofi-Aventis — Marketing Organization

  13. Sep 30, 1997

    Sanofi-Aventis — NDA Secondary Org

  14. Dec 29, 1997

    Vintage — Marketing Organization

  15. Dec 29, 1997

    Cosette — Marketing Organization

  16. Dec 29, 1997

    G & W Laboratories Inc. — Marketing Organization

  17. Dec 29, 1997

    ACP Nimble — Marketing Organization

  18. Jan 1, 1998

    Boehringer Ingelheim — Earliest Phase 1 Sponsor(trial)

2000s

  1. Sep 25, 2000

    Epic Pharma Llc — Marketing Organization

  2. Nov 17, 2000

    Boehringer Ingelheim — Marketing Organization

  3. Nov 17, 2000

    Boehringer Ingelheim — NDA Secondary Org

  4. Sep 18, 2001

    Taro Pharmaceuticals — Marketing Organization

  5. Sep 19, 2001

    Upsher-Smith Laboratories — Marketing Organization

  6. Oct 15, 2001

    Dr. Reddy's Laboratories — Marketing Organization

  7. Mar 29, 2002

    Prinston Inc — Marketing Organization

  8. Jul 1, 2002

    Heritage Pharma — Marketing Organization

  9. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  10. Jun 5, 2003

    Daiichi Sankyo — Marketing Organization

  11. Jun 5, 2003

    Cosette — NDA Secondary Org

  12. Mar 31, 2004

    Lupin — Marketing Organization

  13. Oct 5, 2004

    Corepharma — Marketing Organization

  14. Oct 27, 2004

    Nostrum Laboratories — Marketing Organization

  15. Mar 14, 2006

    Aurobindo Pharma — Marketing Organization

  16. Aug 28, 2006

    Advanz Pharma — Marketing Organization

  17. Aug 28, 2006

    Advanz Pharma — NDA Secondary Org

  18. Mar 16, 2007

    Leading Pharma Llc — Marketing Organization

  19. Jul 20, 2007

    IPCA Laboratories Ltd. — Marketing Organization

  20. Sep 4, 2007

    Jubilant Innovation Ltd. — Marketing Organization

  21. Oct 3, 2007

    Apotex — Marketing Organization

  22. Jan 18, 2008

    Noden Pharmaceuticals — Marketing Organization

  23. Jan 18, 2008

    Noden Pharmaceuticals — NDA Secondary Org

  24. Aug 15, 2008

    Unichem — Marketing Organization

  25. Jul 9, 2009

    Invagen Pharms — Marketing Organization

2010s

  1. Mar 17, 2010

    Glenmark Pharmaceuticals — Marketing Organization

  2. Sep 17, 2010

    Emcure — Marketing Organization

  3. Sep 17, 2010

    Avet Lifesciences — Marketing Organization

  4. Nov 30, 2010

    Alembic — Marketing Organization

  5. Jan 19, 2012

    Sun Pharmaceuticals — Marketing Organization

  6. Aug 9, 2012

    Macleods Pharmaceuticals, Ltd — Marketing Organization

  7. Sep 18, 2012

    Cadista — Marketing Organization

  8. Sep 24, 2012

    Accord Research — Marketing Organization

  9. Sep 28, 2012

    Cipla — Marketing Organization

  10. Apr 19, 2013

    Neogen — Marketing Organization

  11. Feb 25, 2014

    Torrent Pharmaceuticals Limited — Marketing Organization

  12. Jul 23, 2014

    Sciegen Pharmaceticals — Marketing Organization

  13. Jan 15, 2016

    Atlas Chemical Industries — Marketing Organization

  14. Jan 15, 2016

    AkzoNobel — Marketing Organization

  15. Oct 14, 2016

    Zhejiang Hisun Pharmaceutical Co. Ltd. — Marketing Organization

  16. Aug 15, 2017

    Zydus Discovery DMCC — Marketing Organization

  17. Sep 6, 2017

    Huaren Pharmaceutical Co Ltd — Marketing Organization

  18. Feb 11, 2019

    Cadila Healthcare — Marketing Organization

  19. Sep 17, 2019

    Umedica Labs Pvt Ltd — Marketing Organization

2020s

  1. Jul 9, 2020

    Edenbridge Pharms — Marketing Organization

  2. Nov 4, 2021

    Novitium Pharma — Marketing Organization

  3. Feb 23, 2022

    Rubicon Research — Marketing Organization

  4. Aug 11, 2023

    Amneal Pharmaceuticals — Marketing Organization

  5. Sep 29, 2023

    Granules India — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Combination products

Approval history

  • approvedFeb 12, 1959

Chemistry & pharmacology

Loading structure…

SMILES

NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1
Mol. weight
297.739 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Availability
Prescription Only

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • aliskiren / amlodipine / hydrochlorothiazide
  • aliskiren / hydrochlorothiazide
  • amiloride mixture with hydrochlorothiazide
  • amlodipine besylate / valsartan / hydrochlorothiazide
  • amlodipine / valsartan / hydrochlorothiazide
  • apo-hydro
  • apo-hydro
  • behyd
  • benclortriazide
  • benzclortriazide
  • benzylhydrochlorothiazide
  • benzylhydrochlorothiazide
  • benzylhydrochlorothiazide
  • benzylhydrochlorothiazide
  • benzylhydrochlorothiazide
  • bisoprolol fumarate and hydrochlorothiazide
  • esidrex
  • esidrex
  • esidrix
  • esidrix
  • esidrix
  • hctz
  • hctz
  • hctz
  • hgp0918
  • hydochlorothiazide
  • hydochlorthiazide
  • hydrochlorothiazid
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide
  • hydrochlorothiazide intensol
  • hydrochlorothiazide intensol
  • hydrochlorthiazide
  • hydrochlorthiazide
  • hydrochlorthiazide
  • hydrochlorthiazide
  • hydrochlorzide
  • hydrocholorothiazide
  • hydro-d
  • hydro-d
  • hydrodiuril
  • hydrodiuril
  • hydrosaluric
  • hydrosaluric
  • irbesartan / hydrochlorothiazide
  • microzide
  • microzide
  • mk8266
  • mk-8266
  • moduretic
  • moduretic
  • oretic
  • oretic
  • telmisartan / hydrochlorothiazide
  • telmisartan-hydrochlorothiazide
  • thiazide
  • thiazide
  • zide
  • zide

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07120607Phase 1Aug 18, 2025Anhui Medical University
NCT06491940N/AAug 1, 2024RESnTEC, Institute of Research
NCT06362668N/AMay 17, 2024Reprieve Cardiovascular, Inc
NCT06111885Phase 2Apr 30, 2024University of Bern
NCT06205407Phase 1Dec 26, 2023Pfizer
NCT06167265Phase 1Nov 28, 2023Cliantha Research Limited, Genovate Biotechnology Co., Ltd.,
NCT05917275Phase 4Oct 31, 2023Radboud University
NCT06041529Phase 4Sep 14, 2023Catholic University of Korea, Yuhan Pharmaceutical Company
NCT05920005Phase 3Aug 22, 2023Albert Einstein Israelite Hospital, Libbs Farmacêutica LTDA
NCT05897372Phase 2Jun 1, 2023University of Copenhagen
NCT05373264Phase 3Feb 28, 2023University of Groningen
NCT05685277Phase 1Dec 28, 2022Ligand Research, LLC, Pharmtechnology LLC
NCT05443932Phase 4Oct 3, 2022Medical University of Vienna
NCT05552300N/AOct 1, 2022Sichuan University
NCT05526703Phase 3Sep 28, 2022Chong Kun Dang Pharmaceutical
NCT05466734Phase 1Jul 30, 2022Bio-Kinetic Clinical Applications, Genovate Biotechnology Co., Ltd.,
NCT04934228Phase 1Jul 1, 2022University of Kansas
NCT05191862Phase 1Apr 23, 2022Genovate Biotechnology Co., Ltd.,
NCT04964050Phase 1Dec 24, 2021GlaxoSmithKline
NCT04927299Phase 3Jun 30, 2021CICMEX Centro de Investigación Clínica de México, Hospital Hispano S.A. de C.V., Instituto de Investigacion de las Alteraciones del Crecimiento, Desarrollo y Enfermedades Metabolicas, Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V. (BIOMED-GDL), Laboratorios Silanes S.A. de C.V.
Showing 20 of 433 trials
Page 1 / 22

Organizations

Research & Development (313)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
NovartisFor profit666142003
Boehringer IngelheimFor profit383741998
MerckFor profit312851991
Daiichi SankyoFor profit211932002
PfizerFor profit181642002
SanofiFor profit12942003
PRACSFor profit11012002
MylanFor profit10922002
AstraZenecaFor profit7642003
RanbaxyFor profit7712003
Boryung Pharmaceutical CompanyFor profit6632009
GlaxoSmithKlineFor profit6532002
TakedaFor profit6622006
Bristol-Myers SquibbFor profit5332004
EMS S/AFor profit5512016
Forest LaboratoriesFor profit5422007
IlDong Pharmaceutical Co LtdFor profit5522013
SankyoFor profit5422001
Seoul National UniversityAcademic/Hospital5142008
Yonsei UniversityAcademic/Hospital5232008
313 organizations
Page 1 / 16

Marketing (173)

OrganizationOrg typeRelationshipDate
ACP NimbleFor profitMKTGDec 29, 1997
AbbVieFor profitNDA2Jul 6, 1959
Accord ResearchFor profitMKTGSep 24, 2012
ActavisFor profitMKTGAug 20, 1981
ActavisFor profitSYNFeb 11, 2004
Advanz PharmaFor profitMKTGAug 28, 2006
Advanz PharmaFor profitNDA2Aug 28, 2006
AkzoNobelFor profitMKTGJan 15, 2016
AlembicFor profitMKTGNov 30, 2010
AlembicFor profitSYNOct 15, 2012
AllerganFor profitMKTGDec 27, 1996
AllerganFor profitNDA2Dec 27, 1996
Alta PharmaFor profitMKTGJul 21, 1982
AlvogenFor profitMKTGJul 20, 1989
AlvogenFor profitNDA2Jul 20, 1989
AlvogenFor profitSYNJul 20, 1989
Am TherapFor profitMKTG—
American CyanamidFor profitMKTGMar 30, 1983
American Home ProductsFor profitMKTGJul 3, 1985
American Home ProductsFor profitNDA2Jun 15, 1979
AmerisourceBergenFor profitMKTGJun 2, 1977
Amneal PharmaceuticalsFor profitMKTGAug 11, 2023
Ani PharmaceuticalsFor profitMKTGOct 1, 1986
Ani PharmaceuticalsFor profitNDA2Oct 1, 1986
ApotexFor profitMKTGOct 3, 2007
ApotexFor profitSYNMar 12, 2013
ApotexFor profitSYNDec 8, 1987
ApotheconFor profitMKTGOct 12, 1984
ApotheconFor profitNDA2Oct 12, 1984
Ascot PharmaceuticalsFor profitMKTG—
Atlas Chemical IndustriesFor profitMKTGJan 15, 2016
Aurobindo PharmaFor profitMKTGMar 14, 2006
Aurobindo PharmaFor profitSYNJul 20, 2007
Aurobindo PharmaFor profitSYNFeb 22, 2013
Aurobindo PharmaFor profitSYNMar 12, 1979
Aurobindo PharmaFor profitMKTGFeb 11, 2004
Aurobindo PharmaFor profitNDA2Oct 22, 1984
Avet LifesciencesFor profitMKTGSep 17, 2010
Barr LaboratoriesFor profitMKTGMay 30, 1975
Bausch Health CompaniesFor profitSYNOct 31, 1986
Bausch Health CompaniesFor profitMKTGOct 31, 1986
Bausch Health CompaniesFor profitNDA2Oct 31, 1986
Boehringer IngelheimFor profitMKTGNov 17, 2000
Boehringer IngelheimFor profitNDA2Nov 17, 2000
Bristol-Myers SquibbFor profitMKTGNov 30, 1994
Bristol-Myers SquibbFor profitNDA2Nov 30, 1994
CASI Pharmaceuticals, Inc.For profitMKTGJul 31, 1991
Cadila HealthcareFor profitMKTGFeb 11, 2019
CadistaFor profitMKTGSep 18, 2012
Chartwell PharmaceuticalsFor profitMKTGMar 21, 1977
Chartwell PharmaceuticalsFor profitSYNJan 27, 2012
CibaFor profitNDAFeb 12, 1959
CiplaFor profitMKTGSep 28, 2012
CorepharmaFor profitMKTGOct 5, 2004
CosetteFor profitMKTGDec 29, 1997
CosetteFor profitNDA2Jun 5, 2003
DAVA PharmaceuticalsFor profitMKTGNov 5, 1980
Daiichi SankyoFor profitMKTGJun 5, 2003
Dr. Reddy's LaboratoriesFor profitMKTGOct 15, 2001
Duramed ResearchFor profitMKTGMar 2, 1987
Edenbridge PharmsFor profitMKTGJul 9, 2020
Elkins SinnFor profitMKTG—
EmcureFor profitMKTGSep 17, 2010
Epic Pharma LlcFor profitMKTGSep 25, 2000
FosunFor profitMKTGDec 17, 1976
G & W Laboratories Inc.For profitMKTGDec 29, 1997
G D SearleFor profitMKTGJan 27, 1961
GlaxoSmithKlineFor profitMKTGDec 2, 1965
GlaxoSmithKlineFor profitNDA2Dec 2, 1965
Glenmark PharmaceuticalsFor profitMKTGMar 17, 2010
Glenmark PharmaceuticalsFor profitSYNMar 4, 2019
Granules IndiaFor profitMKTGSep 29, 2023
HalseyFor profitMKTG—
Heather PharmaFor profitMKTG—
Heritage PharmaFor profitMKTGJul 1, 2002
Heritage PharmaFor profitSYNJan 20, 1978
Heritage PharmaFor profitSYNJan 20, 1978
HikmaFor profitSYNApr 6, 2010
HikmaFor profitMKTGJan 31, 1977
HikmaFor profitSYNApr 6, 2010
Huaren Pharmaceutical Co LtdFor profitMKTGSep 6, 2017
IPCA Laboratories Ltd.For profitMKTGJul 20, 2007
Impax LaboratoriesFor profitMKTGAug 19, 1977
Invagen PharmsFor profitMKTGJul 9, 2009
Inwood LaboratoriesFor profitMKTGSep 21, 1976
IvaxFor profitMKTGMay 7, 1980
Jubilant Innovation Ltd.For profitMKTGSep 4, 2007
Lannett Company, Inc.For profitSYNJun 24, 1976
Lannett Company, Inc.For profitMKTGMar 10, 1977
Leading Pharma LlcFor profitMKTGMar 16, 2007
Leading Pharma LlcFor profitSYNMar 16, 2007
LederleFor profitMKTGMar 30, 1983
LupinFor profitMKTGMar 31, 2004
LupinFor profitSYNMay 21, 2010
MM PharmaFor profitMKTG—
Macleods Pharmaceuticals, LtdFor profitMKTGAug 9, 2012
MerckFor profitNDA2Feb 24, 1959
MerckFor profitMKTGApr 28, 1995
Morton Grove PharmaceuticalsFor profitMKTG—
Mutual PharmaceuticalFor profitMKTGApr 16, 1981
MylanFor profitSYNAug 3, 1979
MylanFor profitSYNOct 22, 1984
MylanFor profitMKTGOct 11, 1978
NeogenFor profitMKTGApr 19, 2013
Noden PharmaceuticalsFor profitMKTGJan 18, 2008
Noden PharmaceuticalsFor profitNDA2Jan 18, 2008
Nostrum LaboratoriesFor profitMKTGOct 27, 2004
NovartisFor profitNDA2Feb 12, 1959
NovartisFor profitMKTGMay 26, 1976
Novitium PharmaFor profitMKTGNov 4, 2021
OrganonFor profitNDA2Apr 28, 1995
Oxford PharmaceuticalsFor profitMKTGNov 5, 1980
Par PharmaceuticalsFor profitMKTGOct 21, 1985
Par PharmaceuticalsFor profitSYNOct 26, 2016
Parke-DavisFor profitMKTG—
PfizerFor profitSYNDec 28, 1999
PfizerFor profitNDA2Jan 27, 1961
PlivaFor profitMKTGApr 26, 1996
Prinston IncFor profitMKTGMar 29, 2002
Puracap PharmaceuticalFor profitMKTGNov 6, 1985
Quantum PharmaceuticalFor profitMKTG—
Rising PharmaceuticalsFor profitMKTGJan 23, 1986
Rising PharmaceuticalsFor profitMKTGOct 31, 1991
Roxane LaboratoriesFor profitMKTGJul 13, 1978
Rubicon ResearchFor profitMKTGFeb 23, 2022
SandozFor profitMKTGApr 16, 1981
Sanofi-AventisFor profitMKTGSep 30, 1997
Sanofi-AventisFor profitNDA2Sep 30, 1997
ScheringFor profitMKTGApr 6, 1987
Schering-PloughFor profitNDA2Apr 6, 1987
Sciegen PharmaceticalsFor profitMKTGJul 23, 2014
SolvayFor profitMKTGMay 3, 1977
Strides Pharma ScienceFor profitMKTGOct 21, 1985
Sun PharmaceuticalsFor profitMKTGJan 19, 2012
Sun PharmaceuticalsFor profitSYNMar 27, 2007
Sun PharmaceuticalsFor profitSYNJul 1, 2002
Sun PharmaceuticalsFor profitSYNOct 3, 1974
SuperpharmFor profitMKTGDec 28, 1984
Taro PharmaceuticalsFor profitMKTGSep 18, 2001
TevaFor profitSYNJan 12, 1973
TevaFor profitSYNFeb 7, 1985
TevaFor profitSYNMar 26, 1993
TevaFor profitSYNApr 6, 2010
TevaFor profitSYNDec 11, 2012
TevaFor profitMKTGJan 24, 1975
TevaFor profitNDA2Mar 26, 1993
Torrent Pharmaceuticals LimitedFor profitMKTGFeb 25, 2014
Torrent Pharmaceuticals LimitedFor profitSYNApr 6, 2010
Torrent Pharmaceuticals LimitedFor profitSYNApr 10, 2012
UCBFor profitMKTGJun 27, 1997
UCBFor profitNDA2Jun 27, 1997
Umedica Labs Pvt LtdFor profitMKTGSep 17, 2019
UnichemFor profitSYNJul 21, 2017
UnichemFor profitMKTGAug 15, 2008
Upsher-Smith LaboratoriesFor profitMKTGSep 19, 2001
Upsher-Smith LaboratoriesFor profitSYNApr 19, 1982
Validus PharmaceuticalsFor profitMKTGDec 31, 1984
Validus PharmaceuticalsFor profitNDA2Dec 31, 1984
VanguardFor profitMKTGDec 7, 1981
VintageFor profitMKTGDec 29, 1997
VitarineFor profitMKTG—
Warner ChilcottFor profitMKTGJan 26, 1988
Watson PharmaceuticalsFor profitMKTGJan 7, 1977
Watson PharmaceuticalsFor profitSYNSep 15, 2011
Watson PharmaceuticalsFor profitSYNOct 22, 2012
West-Ward PharmaceuticalFor profitMKTGMay 10, 1984
West-Ward PharmaceuticalFor profitSYNApr 6, 2010
Whiteworth Towne PaulsenFor profitMKTGJul 2, 1974
WyethFor profitMKTGJun 15, 1979
Zhejiang Hisun Pharmaceutical Co. Ltd.For profitMKTGOct 14, 2016
Zydus Discovery DMCCFor profitMKTGAug 15, 2017
Zydus Discovery DMCCFor profitSYNOct 6, 2010
Zydus Discovery DMCCFor profitSYNNov 27, 2017