← Mechanisms of action
PTGS2
SINGLE PROTEINHomo sapiens
Preferred name: Cyclooxygenase-2 ChEMBL ↗
Linked proteins
Drugs acting on this target (45)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| rebamipide | Activator | experimental | Small molecule | PTGS2 activator |
| ketorolac (acuvail) | Antagonist | approved | Small molecule | PTGS2 antagonist |
| stp707 | Antisense inhibitor | experimental | Nucleic acid | PTGS2 antisense inhibitor |
| aceclofenac | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| apigenin | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| apricoxib | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| carprofen | Inhibitor | approved | Small molecule | PTGS2 inhibitor |
| celecoxib (celebrex) | Inhibitor | approved | Small molecule | PTGS2 inhibitor |
| cidan | Inhibitor | experimental | Botanical | PTGS2 inhibitor |
| cimicoxib | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| dexibuprofen | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| ecp-1014 | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| etodolac (lodine) | Inhibitor | approved | Small molecule | PTGS2 inhibitor |
| etoricoxib (Gencox) | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| Felbinac | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| gski181771x | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| gw-406381 | Inhibitor | experimental | Small molecule | Cyclooxygenase-2 inhibitor |
| gw406381 | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| harpagoside | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| htx-009 | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| iguratimod | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| imrecoxib | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| japrolox | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| jc-013 | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| k-103-ip | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| kp-1199 | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| lumiracoxib | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| lysyl-ketoprofen | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| meloxicam (mobic) | Inhibitor | approved | Small molecule | PTGS2 inhibitor |
| methosulide | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| nabumetone (relafen) | Inhibitor | approved | Small molecule | PTGS2 inhibitor |
| nimesulide | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| Otenaproxesul | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| parecoxib | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| pelubiprofen | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| polmacoxib | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| pranoprofen | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| propyphenazone | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| rofecoxib (Vioxx) | Inhibitor | withdrawn | Small molecule | PTGS2 inhibitor |
| sinomenine | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| stp705 | Inhibitor | experimental | Nucleic acid | PTGS2 inhibitor |
| tolfenamic acid | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| trigonellamide | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| trolamine salicylate | Inhibitor | experimental | Small molecule | PTGS2 inhibitor |
| valdecoxib (Bextra) | Inhibitor | approved | Small molecule | PTGS2 inhibitor |