aceclofenac
Small moleculeexperimental
Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. — Wikipedia
Clinical trial activity
25 trials · 38 clinical orgs · 0 marketing orgs
Phase 1
10
Phase 2
6
Phase 3
3
Phase 4
4
Earliest trial started Mar 1, 2007 (NCT04144101)
Timeline
Indications
Studied for
- Acute Pain · Phase 3
- Anti-Ulcer Agents · Phase 1
- Arthritis, Rheumatoid · Phase 4
- Bipolar Disorder · Phase 2
- Drug Interactions · Phase 1
- Healthy Volunteers · Phase 1
- Major Depressive Disorder · Phase 2
- Osteoarthritis · Phase 4
- Osteoarthritis, Knee · Phase 4
- Pulpitis · Phase 2/Phase 3
- Stomach Diseases · Phase 4
- Stress Disorders, Post-Traumatic · Phase 2
- Therapeutic Equivalency · Phase 1
Mechanism of action
- Cyclooxygenase-2INHIBITOR
PTGS2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)Cc1c(-c2ccccc2)c(-c2ccccc2)nn1-c1ccccc1- Mol. weight
- 354.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAceclofenac ↗
- ChEMBLCHEMBL93645 ↗
- ChEMBLCHEMBL2104795 ↗
Also known as
- 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester
- 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester
- 2-((2,6-dichlorophenyl)amino)phenylacetoxyacetic acid
- 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid
- 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid
- 2-[(2',6'-dichlorophenyl)amino]phenylacetoxyacetic acid
- 2-[(2',6'-dichlorophenyl)amino]phenylacetoxyacetic acid
- aceclofar
- aceclofenac
- aceclofenac
- aceclofenac
- aceclofenac
- aceclofenac
- aceclofenac
- aceclofenac
- aceclofenac
- acéclofénac
- acéclofénac
- aceclofenac betadex
- aceclofenac betadex
- aceclofenaco
- aceclofenaco
- aceclofenacum
- aceclofenacum
- airtal
- airtal difucrem
- aital
- beofenac
- biofenac
- bristaflam
- bristaflam
- clanza cr
- falcol
- falcol difucrem
- fed
- gerbin
- gerbin
- gerbin
- gerbin difucrem
- glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester
- glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester
- hifenac
- isofezolac
- isofezolac
- isofezolac
- isofezolac
- nvp-1203
- pr-82/3
- pr-82/3
- preservex
- preservex
- preservex
- sanein
- sofenac
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06656416 | Phase 2 | Oct 2, 2024 | Alto Neuroscience |
| NCT05712187 | Phase 2 | Jan 10, 2023 | Alto Neuroscience |
| NCT05980572 | N/A | Jan 1, 2023 | Chang Gung University |
| NCT05558150 | Phase 1 | Nov 11, 2022 | Il-Yang Pharm. Co., Ltd., Yonsei University |
| NCT05419869 | Phase 2 | Jun 1, 2022 | Alto Neuroscience |
| NCT05339373 | Phase 1 | Apr 15, 2022 | Government of Russia, Pharmtechnology LLC |
| NCT05237297 | Phase 1 | Feb 17, 2022 | Il-Yang Pharm. Co., Ltd., Yonsei University |
| NCT05117632 | Phase 2 | Nov 30, 2021 | Alto Neuroscience |
| NCT05181124 | Phase 1 | Mar 5, 2021 | Onconic Therapeutics Inc. |
| NCT04181437 | Phase 1 | Jun 15, 2020 | Kyungpook University, Navipharm Corporation |
| NCT04639804 | Phase 1 | Jun 6, 2020 | Chonbuk National University, Inno.N |
| NCT04082975 | Phase 3 | Nov 4, 2019 | Navipharm Corporation, Yonsei University |
| NCT03341832 | Phase 2 | Jan 31, 2018 | Inje University, Navipharm Corporation, Wonkwang University, Yonsei University |
| NCT03127046 | Phase 1 | Mar 31, 2017 | Chonbuk National University, DongWha Pharmaceutical Company |
| NCT02883569 | N/A | Sep 1, 2016 | Seoul National University, Yonsei University |
| NCT03146481 | Phase 2/Phase 3 (Phase 3) | Jul 1, 2016 | Cairo University |
| NCT02384928 | N/A | Sep 9, 2015 | Jaseng Hospital of Korean Medicine |
| NCT02682524 | Phase 4 | Aug 1, 2015 | Daewon Pharmaceutical Co., Ltd. |
| NCT03335007 | Phase 2/Phase 3 (Phase 3) | May 31, 2015 | Cairo University |
| NCT02289404 | Phase 1 | Jan 1, 2015 | Gachon University, Navipharm Corporation |
Showing 20 of 25 trials
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Organizations
Research & Development (38)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Yonsei University | Academic/Hospital | 6 | 0 | 5 | 2012 |
| Navipharm Corporation | For profit | 5 | 5 | 3 | 2014 |
| Alto Neuroscience | For profit | 4 | 4 | 1 | 2021 |
| Chonbuk National University | Academic/Hospital | 3 | 0 | 2 | 2012 |
| Cairo University | Academic/Hospital | 2 | 2 | 1 | 2015 |
| Il-Yang Pharm. Co., Ltd. | For profit | 2 | 2 | 1 | 2022 |
| Inje University | Academic/Hospital | 2 | 0 | 2 | 2012 |
| Kyungpook University | Academic/Hospital | 2 | 0 | 2 | 2012 |
| Seoul National University | Academic/Hospital | 2 | 1 | 2 | 2012 |
| Wonkwang University | Academic/Hospital | 2 | 0 | 2 | 2012 |
| Ajou University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Chang Gung University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Chonnam National University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Chung-Ang University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Chung Shan Medical University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Daegu Catholic University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Daewon Pharmaceutical Co., Ltd. | For profit | 1 | 1 | 1 | 2015 |
| Dong-A Pharmaceutical | For profit | 1 | 1 | 1 | 2012 |
| DongWha Pharmaceutical Company | For profit | 1 | 1 | 1 | 2017 |
38 organizations
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