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polmacoxib

Small moleculeexperimental

Polmacoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It was developed as CG100649 and approved for use in South Korea in February 2015. It inhibits the enzymes carbonic anhydrase and COX-2. A study in healthy volunteers showed drug effects on urinary prostaglandin metabolites for both polmacoxib and celecoxib that suggest a similar cardiovascular risk profile. Further work by this group developed dose-exposure relationships of polmacoxib to guide clinical development strategies. — Wikipedia

Clinical trial activity

10 trials · 10 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
3
Phase 3
1
Phase 4
0

Earliest trial started Oct 1, 2007 (NCT00530452)

Timeline

2000s

  1. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2013

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC1(C)OC(c2ccc(S(N)(=O)=O)cc2)=C(c2cccc(F)c2)C1=O
Mol. weight
361.39 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • cg100649
  • cg100649
  • cg100649
  • polmacoxib
  • polmacoxib
  • polmacoxib
  • polmacoxib

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06590714N/AAug 23, 2024Dong-A Pharmaceutical, Eulji University, Seoul National University
NCT05370716Phase 1Nov 11, 2019CrystalGenomics, Inc.
NCT03774355Phase 1Dec 17, 2018CrystalGenomics, Inc., Seoul National University
NCT03775629Phase 1Dec 1, 2018CrystalGenomics, Inc., Seoul National University
NCT01765296Phase 3Mar 1, 2013CrystalGenomics, Inc., Seoul National University
NCT01341405Phase 2Apr 1, 2011CrystalGenomics, Inc., Ewha Womans University, Korea University, Seoul National University, University of Ulsan, Yonsei University
NCT01154790Phase 1Jun 1, 2010CrystalGenomics, Inc.
NCT01154764Phase 1Oct 1, 2009CrystalGenomics, Inc., University of Ulsan
NCT00780325Phase 1Oct 1, 2008CrystalGenomics, Inc., University of Pennsylvania
NCT00530452Phase 2Oct 1, 2007CrystalGenomics, Inc., IQVIA
Showing 10 of 10 trials
Page 1 / 1

Organizations

Research & Development (10)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
CrystalGenomics, Inc.For profit9832007
Seoul National UniversityAcademic/Hospital5042011
University of UlsanAcademic/Hospital2022009
Dong-A PharmaceuticalFor profit1012024
Eulji UniversityAcademic/Hospital1112024
Ewha Womans UniversityAcademic/Hospital1012011
IQVIAFor profit1012007
Korea UniversityAcademic/Hospital1012011
University of PennsylvaniaAcademic/Hospital1112008
Yonsei UniversityAcademic/Hospital1012011
10 organizations
Page 1 / 1