carprofen
Small moleculeapproved
Approved
Dec 31, 1987
Carprofen is an anti-inflammatory drug developed in Japan by Nippon Roche Research Center. Carprofen, as many NSAIDs, selectively inhibits COX-2 and was shown to suppress inflammation in vitro, using osteoarthritis models. The drug was approved by FDA for human use under the name Ridamyl, however, now it is sold only for veterinary purposes and prescribed for the treatment of postoperative pain and the relief of pain and inflammation associated with osteoarthritis in dogs. — NCATS
Clinical trial activity
1 trials · 1 clinical orgs · 1 marketing orgs
Phase 1
1
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2024 (NCT06535126)
Timeline
Indications
Studied for
Mechanism of action
- Cyclooxygenase-2INHIBITOR
PTGS2 inhibitor
Selective
Approval history
- approvedDec 31, 1987
Chemistry & pharmacology
Loading structure…
SMILES
CC(C(O)=O)C1=CC2=C(C=C1)C3=C(N2)C=CC(Cl)=C3- Mol. weight
- 273.714 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaCarprofen ↗
- NCATSFFL0D546HO ↗
- ChEMBLCHEMBL1316 ↗
Also known as
- (+/-)-2-(3-chloro-9h-carbazol-7-yl)propanoic acid
- (+/-)-2-(3-chloro-9h-carbazol-7-yl)propanoic acid
- 2-(6-chloro-9h-carbazol-2-yl)-propionic acid
- 2-(6-chloro-9h-carbazol-2-yl)-propionic acid
- 6-chloro-alpha-methyl-9h-carbazole-2-acetic acid
- 6-chloro-alpha-methyl-9h-carbazole-2-acetic acid
- (+-)-6-chloro-alpha-methylcarbazole-2-acetic acid
- (+-)-6-chloro-alpha-methylcarbazole-2-acetic acid
- 6-chloro-alpha-methylcarbazole-2-acetic acid
- c 5720
- carprodyl
- carprofen
- carprofen
- carprofen
- carprofen
- carprofen
- carprofen
- carprofen
- carprofen
- carprofen
- carprofène
- carprofène
- carprofen, (+-)-isomer
- carprofeno
- carprofeno
- carprofen, (r)-isomer
- carprofen, (s)-isomer
- carprofenum
- carprofenum
- (+-)-isomer of carprofen
- rimadyl
- rimadyl
- rimadyl
- rimadyl
- (r)-isomer of carprofen
- ro 205720
- ro 205720
- ro 205720
- ro 205720
- ro 205720
- ro 205720
- ro 20-5720
- ro-205720
- ro-205720000
- ro-205720000
- (s)-isomer of carprofen
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06535126 | Phase 1 | Jun 1, 2024 | Industrial Microbiology LLP |
Showing 1 of 1 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Industrial Microbiology LLP | For profit | 1 | 1 | 1 | 2024 |
1 organizations
Page 1 / 1
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Roche | For profit | NDA | Dec 31, 1987 |