orantinib
Small moleculeexperimental
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
2
Phase 3
1
Phase 4
0
Earliest trial started Jul 1, 2001 (NCT00024206)
Timeline
Indications
Mechanism of action
KDR inhibitor
Ph 3 trial discontinued, compound on hold?
- Fibroblast growth factor receptorINHIBITOR
Fibroblast growth factor receptor inhibitor
Ph 3 trial discontinued, compound on hold?
Platelet-derived growth factor receptor inhibitor
Ph 3 trial discontinued, compound on hold?
Chemistry & pharmacology
Loading structure…
SMILES
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O- Mol. weight
- 310.35 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL274654 ↗
Also known as
- 5-((1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-propanoic acid
- orantinib
- orantinib
- orantinib
- orantinib
- orantinib
- su006668
- su6668
- su 6668
- su-6668
- su-6668
- tsu 68
- tsu-68
- tsu-68
- tsu-68
- (z)-3-(2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1h-pyrrol-3-yl)-propionic acid
- (z)-3-(2,4-dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1h-pyrrol-3-yl)propionic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01465464 | Phase 3 | Dec 1, 2010 | Otsuka |
| NCT00784290 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2003 | Otsuka, Yamanashi Prefectural Central Hospital |
| NCT00024063 | Phase 1 | Sep 13, 2001 | National Cancer Institute (NCI), University of California, Los Angeles |
| NCT00024206 | Phase 1 | Jul 1, 2001 | National Cancer Institute (NCI), University of Texas at Houston |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 2 | 1 | 1 | 2001 |
| Otsuka | For profit | 2 | 2 | 2 | 2003 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2001 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2001 |
| Yamanashi Prefectural Central Hospital | Academic/Hospital | 1 | 0 | 1 | 2003 |
5 organizations
Page 1 / 1