← Mechanisms of action
OPRM
SINGLE PROTEINHomo sapiens
Preferred name: Mu opioid receptor ChEMBL ↗
Linked proteins
Drugs acting on this target (61)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| alfentanil (alfenta) | Agonist | approved | Small molecule | OPRM agonist |
| anileridine (leritine) | Agonist | approved | Small molecule | OPRM agonist |
| axomadol | Agonist | experimental | Small molecule | OPRM agonist |
| benzhydrocodone (Apadaz) | Agonist | approved | Small molecule | OPRM agonist |
| buprenorphine | Agonist | approved | Small molecule | OPRM agonist |
| Carfentanil | Agonist | experimental | Small molecule | OPRM agonist |
| difenoxin (Motofen) | Agonist | approved | Small molecule | OPRM agonist |
| dihydrocodeine | Agonist | approved | Small molecule | OPRM agonist |
| diphenoxylate | Agonist | approved | Small molecule | OPRM agonist |
| dynorphin 1-13 | Agonist | experimental | Peptide | OPRM agonist |
| eluxadoline (viberzi) | Agonist | approved | Small molecule | OPRM agonist |
| faxeladol | Agonist | experimental | Small molecule | OPRM agonist |
| fentanyl (Innovar) | Agonist | approved | Small molecule | OPRM agonist |
| frakefamide | Agonist | experimental | Small molecule | OPRM agonist |
| heroin | Agonist | experimental | Small molecule | OPRM agonist |
| hydromorphone (diladid) | Agonist | approved | Small molecule | OPRM agonist |
| ketobemidone (Ketogan) | Agonist | experimental | Small molecule | OPRM agonist |
| levomethadone | Agonist | experimental | Small molecule | OPRM agonist |
| levomethadyl acetate (orlaam) | Agonist | approved | Small molecule | OPRM agonist |
| levorphanol tartrate (levo-dromoran) | Agonist | approved | Small molecule | OPRM agonist |
| loperamide (imodium) | Agonist | approved | Small molecule | OPRM agonist |
| meb-1170 | Agonist | experimental | Small molecule | OPRM agonist |
| meperidine (demerol) | Agonist | approved | Small molecule | OPRM agonist |
| methadone (methadose) | Agonist | approved | Small molecule | OPRM agonist |
| morphine | Agonist | approved | Small molecule | OPRM agonist |
| norbuprenorphine | Agonist | experimental | Small molecule | OPRM agonist |
| o-desmethyltramadol | Agonist | experimental | Small molecule | OPRM agonist |
| oliceridine (Olinvyk) | Agonist | approved | Small molecule | OPRM agonist |
| oxycodegol | Agonist | experimental | Small molecule | OPRM agonist |
| oxycodone (oxycontin) | Agonist | approved | Small molecule | OPRM agonist |
| piritramide | Agonist | experimental | Small molecule | OPRM agonist |
| propoxyphene (Darvon) | Agonist | approved | Small molecule | OPRM agonist |
| remifentanil (ultiva) | Agonist | approved | Small molecule | OPRM agonist |
| sbs-1000 | Agonist | experimental | Small molecule | OPRM agonist |
| sr419 | Agonist | experimental | Small molecule | OPRM agonist |
| sufentanil | Agonist | approved | Small molecule | OPRM agonist |
| taglidine | Agonist | experimental | Small molecule | OPRM agonist |
| tapentadol (nucynta) | Agonist | approved | Small molecule | OPRM agonist |
| tramadol (Ultram) | Agonist | approved | Small molecule | OPRM agonist |
| trimebutine | Agonist | experimental | Small molecule | OPRM agonist |
| 6beta-naltrexol | Antagonist | experimental | Small molecule | OPRM antagonist |
| alvimopan (entereg) | Antagonist | approved | Small molecule | OPRM antagonist |
| axelopran | Antagonist | experimental | Small molecule | OPRM antagonist |
| bevenopran | Antagonist | experimental | Small molecule | OPRM antagonist |
| cp-866,087 | Antagonist | experimental | Small molecule | OPRM antagonist |
| cp-866087 | Antagonist | experimental | Small molecule | Mu opioid receptor antagonist |
| gsk-1521498 | Antagonist | experimental | Small molecule | OPRM antagonist |
| levallorphan (lorfan) | Antagonist | approved | Small molecule | OPRM antagonist |
| methylnaltrexone (relistor) | Antagonist | approved | Small molecule | OPRM antagonist |
| methylsamidorphan | Antagonist | experimental | Small molecule | OPRM antagonist |
| naldemedine (symproic) | Antagonist | approved | Small molecule | OPRM antagonist |
| naloxegol (movantik) | Antagonist | approved | Small molecule | OPRM antagonist |
| naloxol | Antagonist | experimental | Small molecule | OPRM antagonist |
| samidorphan (Lybalvi) | Antagonist | approved | Small molecule | OPRM antagonist |
| sebacoyl dinalbuphine ester (Naldebain) | Antagonist | experimental | Small molecule | OPRM antagonist |
| butorphanol (stadol) | Partial agonist | approved | Small molecule | OPRM partial agonist |
| dezocine (dalgan) | Partial agonist | approved | Small molecule | OPRM partial agonist |
| orp-101 | Partial agonist | experimental | Small molecule | Mu opioid receptor partial agonist |
| Thienorphine | Partial agonist | experimental | Small molecule | OPRM partial agonist |
| trk-130 | Partial agonist | experimental | Small molecule | OPRM partial agonist |
| wy22811 | Partial agonist | experimental | Small molecule | Mu opioid receptor partial agonist |