sebacoyl dinalbuphine ester
Trade name: Naldebain
Small moleculeexperimental
Dinalbuphine sebacate (DNS), also known as nalbuphine sebacate or as sebacoyl dinalbuphine ester (SDE) and sold under the brand name Naldebain, is a non-controlled opioid analgesic which is used as a 7-day long-acting injection in the treatment of moderate to severe postoperative pain. — Wikipedia
Clinical trial activity
7 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
2
Phase 4
2
Earliest trial started Dec 1, 2012 (NCT02468128)
Timeline
Indications
Approved for
Mechanism of action
- Mu opioid receptorANTAGONIST
OPRM antagonist
- Kappa opioid receptorPARTIAL AGONIST
OPRK1 partial agonist
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDinalbuphine sebacate ↗
Also known as
- sebacoyl dinalbuphine ester
- sebacoyl dinalbuphine ester
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06344169 | Phase 2/Phase 3 (Phase 3) | Apr 15, 2024 | Dalin Tzu Chi General Hospital, Hualien Tzu Chi Hospital |
| NCT05842733 | Phase 2 | Jul 25, 2023 | Sinew Pharma Inc., Taipei Veteran General hospital |
| NCT05187520 | Phase 2 | Sep 1, 2022 | I-Shou University |
| NCT03854851 | Phase 4 | Mar 1, 2019 | China Medical University |
| NCT03713216 | Phase 4 | Jul 1, 2018 | Cathay General Hospital |
| NCT02446301 | Phase 1 | Jan 1, 2015 | Lumosa Therapeutics Co., Ltd. |
| NCT02468128 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2012 | Chang Gung University, Lumosa Therapeutics Co., Ltd. |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Lumosa Therapeutics Co., Ltd. | For profit | 2 | 2 | 2 | 2012 |
| Cathay General Hospital | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Chang Gung University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| China Medical University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Dalin Tzu Chi General Hospital | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Hualien Tzu Chi Hospital | Academic/Hospital | 1 | 0 | 1 | 2024 |
| I-Shou University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Sinew Pharma Inc. | For profit | 1 | 1 | 1 | 2023 |
| Taipei Veteran General hospital | Government | 1 | 0 | 1 | 2023 |
9 organizations
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