anileridine

Trade name: leritine

Small moleculeapproved

Approved

Aug 15, 1957

Aniledrine is a narcotic pain reliver. The drug was prescribed as an analgesic in anaesthesia (Leritine brand name), however, it is no longer available on the market. Although the exact mechanism is not fully understood, aniledrine appears to elicit its action by binding to endorphine receptors in CNS. — NCATS

Clinical trial activity

0 trials · 0 clinical orgs · 1 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Timeline

1950s

Aug 15, 1957
Merck — Earliest FDA Approval
Aug 15, 1957
Merck — NDA Secondary Org
Aug 15, 1957
Merck — NDA Organization

Indications

Approved for

Pain

Mechanism of action

Kappa opioid receptorAGONIST
OPRK1 agonist
- Kappa-type opioid receptor (OPRK1) ↗
Mu opioid receptorAGONIST
OPRM agonist
- Mu-type opioid receptor (OPRM) ↗

Approval history

approvedAug 15, 1957

Chemistry & pharmacology

Loading structure…

SMILES

CCOC(=O)C1(CCN(CCC2=CC=C(N)C=C2)CC1)C3=CC=CC=C3

Mol. weight: 352.4699 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Parenteral
Availability: Discontinued

Oral

Parenteral

Yes

Topical

Sources

Also known as

1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester
1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester
adopol
alidine
anileridina
anileridina
anileridine
anileridine
anileridine
anileridine
anileridine
anileridine
anileridine
anileridine
anileridine
anileridine dihydrochloride
anileridine dihydrochloride
anileridine hcl
anileridine hcl
anileridine hcl
anileridine hydrochloride
anileridine hydrochloride
anileridine hydrochloride
anileridine hydrochloride
anileridine hydrochloride
anileridine monohydrochloride
anileridine monohydrochloride
anileridine phosphate
anileridine phosphate
anileridine phosphate
anileridine phosphate
anileridine phosphate
anileridine phosphate (1:1)
anileridinum
anileridinum
apidol
ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylate
ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylate
ethyl 1-(4-aminophenethyl)-4-phenylisonipecotate
ethyl 1-(4-aminophenethyl)-4-phenylisonipecotate
ethyl 1-(p-aminophenethyl)-4-phenylisonipecotate
ethyl 1-(p-aminophenethyl)-4-phenylisonipecotate
leritin
leritin
leritin
leritine
leritine
leritine
n-(beta-(p-aminophenyl)ethyl)-4-phenyl-4-carbethoxypiperidine
n-(beta-(p-aminophenyl)ethyl)-4-phenyl-4-carbethoxypiperidine
n-beta-(p-aminophenyl)ethylnormeperidine
n-beta-(p-aminophenyl)ethylnormeperidine
nipecotan
n-β-(p-aminophenyl)ethylnormeperidine
n-β-(p-aminophenyl)ethylnormeperidine

Organizations

Marketing (2)

Organization	Org type	Relationship	Date
Merck	For profit	NDA2	Aug 15, 1957
Merck	For profit	NDA	Aug 15, 1957