CDEK
← Mechanisms of action

ERBB2

SINGLE PROTEINHomo sapiens
Preferred name: Receptor protein-tyrosine kinase erbB-2 ChEMBL ↗

Linked proteins

Drugs acting on this target (239)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
bat1006AntagonistexperimentalmAbERBB2 antagonist
BL-B01D1AntagonistexperimentalmAbERBB2 antagonist
bl-m07d1AntagonistexperimentalSmall moleculeERBB2 antagonist
df1001AntagonistexperimentalRecombinant proteinERBB2 antagonist
elvn-002AntagonistexperimentalSmall moleculeERBB2 antagonist
fam-trastuzumab deruxtecan-nxki (Enhertu)AntagonistapprovedmAbERBB2 antagonist
glsi-100AntagonistexperimentalPeptideERBB2 antagonist
hs-10376AntagonistexperimentalSmall moleculeERBB2 antagonist
inetetamabAntagonistexperimentalmAbERBB2 antagonist
jskn003AntagonistexperimentalmAbERBB2 antagonist
km257AntagonistexperimentalmAbERBB2 antagonist
sph5030AntagonistexperimentalSmall moleculeERBB2 antagonist
ssgj-705AntagonistexperimentalmAbERBB2 antagonist
tl938AntagonistexperimentalSmall moleculeERBB2 antagonist
tqb2102AntagonistexperimentalSmall moleculeERBB2 antagonist
tqb2930AntagonistexperimentalmAbERBB2 antagonist
yh32367AntagonistexperimentalmAbERBB2 antagonist
yh42946AntagonistexperimentalSmall moleculeERBB2 antagonist
[177lu]lu-nns309Binding agentexperimentalSmall moleculeERBB2 binding agent
177lu-rad202Binding agentexperimentalPeptideERBB2 binding agent
68ga labeled her2 affibodyBinding agentexperimentalmAbERBB2 binding agent
99mtc-mirc213Binding agentexperimentalPeptideERBB2 binding agent
aby-025Binding agentexperimentalSmall moleculeERBB2 binding agent
bat8010Binding agentexperimentalmAbERBB2 binding agent
btrc4017aBinding agentexperimentalmAbERBB2 binding agent
erb-38Binding agentexperimentalmAbERBB2 binding agent
ertumaxomabBinding agentexperimentalmAbERBB2 binding agent
fam-trastuzumab deruxtecan-nxki (Enhertu)Binding agentapprovedmAbReceptor protein-tyrosine kinase erbB-2 binding agent
gbr 1302Binding agentexperimentalmAbERBB2 binding agent
imm2902Binding agentexperimentalmAbERBB2 binding agent
MDX-H210Binding agentexperimentalmAbERBB2 binding agent
mm-302Binding agentexperimentalmAbERBB2 binding agent
rc48-adcBinding agentexperimentalmAbReceptor tyrosine-protein kinase erbB-2 binding agent
sar443216Binding agentexperimentalmAbERBB2 binding agent
trastuzumab emtansine (kadcyla)Binding agentapprovedmAbERBB2 binding agent
zv0203Binding agentexperimentalmAbERBB2 binding agent
ertumaxomabCross-linking agentexperimentalmAbReceptor protein-tyrosine kinase erbB-2 cross-linking agent
mdx-210Cross-linking agentexperimentalmAbReceptor protein-tyrosine kinase erbB-2 cross-linking agent
adenoviral vector encoding rat her-2/neuImmunity, activeexperimentalVaccineERBB2 immunity, active
adher-2/neu transduced dendritic cellsImmunity, activeexperimentalVaccineERBB2 immunity, active
adher2dcImmunity, activeexperimentalVaccineERBB2 immunity, active
adxs31-164Immunity, activeexperimentalVaccineERBB2 immunity, active
ae37 peptide vaccineImmunity, activeexperimentalBiologicalERBB2 immunity, active
anti-her2/her3 dendritic cell vaccineImmunity, activeexperimentalVaccineERBB2 immunity, active
ast-301Immunity, activeexperimentalVaccineERBB2 immunity, active
autologous ad her2 dendritic cellsImmunity, activeexperimentalVaccineERBB2 immunity, active
avx901Immunity, activeexperimentalVaccineERBB2 immunity, active
bvac-bImmunity, activeexperimentalVaccineERBB2 immunity, active
dher2Immunity, activeexperimentalVaccineERBB2 immunity, active
dn24-02Immunity, activeexperimentalVaccineERBB2 immunity, active
Donaperminogene seltoplasmidImmunity, activeexperimentalVaccineERBB2 immunity, active
ep-101Immunity, activeexperimentalVaccineERBB2 immunity, active
etbx-021Immunity, activeexperimentalVaccineERBB2 immunity, active
gp2 peptideImmunity, activeexperimentalVaccineERBB2 immunity, active
gsk719125Immunity, activeexperimentalVaccineERBB2 immunity, active
her-2 icd peptideImmunity, activeexperimentalVaccineERBB2 immunity, active
her-2 pulsed dc1Immunity, activeexperimentalVaccineERBB2 immunity, active
her-2 pulsed dendritic cellsImmunity, activeexperimentalVaccineERBB2 immunity, active
her-2/neu peptide vaccineImmunity, activeexperimentalVaccineERBB2 immunity, active
her2 vaccineImmunity, activeexperimentalVaccineERBB2 immunity, active
her2/neu peptideImmunity, activeexperimentalPeptideERBB2 immunity, active
imu-131Immunity, activeexperimentalVaccineERBB2 immunity, active
mvf-her-2 (266-296)Immunity, activeexperimentalVaccineERBB2 immunity, active
mvf-her-2(597-626)Immunity, activeexperimentalVaccineERBB2 immunity, active
mvf-her-2(628-647)-crl 1005 vaccineImmunity, activeexperimentalVaccineERBB2 immunity, active
nelipepimut-sImmunity, activeexperimentalVaccineERBB2 immunity, active
tgfbeta resistant her2/ebv-ctlsImmunity, activeexperimentalCell therapyERBB2 immunity, active
tpiv100Immunity, activeexperimentalVaccineERBB2 immunity, active
v932Immunity, activeexperimentalVaccineERBB2 immunity, active
vrp-her2Immunity, activeexperimentalBiologicalERBB2 immunity, active
131i-sgmib anti-her2 vhh1Immunity, passiveexperimentalmAbERBB2 immunity, passive
89zr-trastuzumabImmunity, passiveexperimentalmAbERBB2 immunity, passive
ab-201Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
ace1702Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
actr707Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
aur-201Immunity, passiveexperimentalGene therapyERBB2 immunity, passive
cd146/her2 car-t cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
ct-0508Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
ct-0525Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
ft825Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
her-2 car-t cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
her.car cmv-specific ctlsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
her2 car-t cellImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
her2-specific t cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
her2-targeted car-m cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
her2bi-armed activated t cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
htr2 t cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
hyposti.car-her2 t cellsImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
ono-7428Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
rqr8/atrbc1 car tImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
sc-car4brainImmunity, passiveexperimentalCell therapyERBB2 immunity, passive
tils and car-tils targeting her2, mesothelin, psca, muc1, lewis-y, gpc3, axl, egfr, claudin18.2/6, ror1, gd1, or b7-h3Immunity, passiveexperimentalCell therapyERBB2 immunity, passive
111-in-aby-025InhibitorexperimentalmAbERBB2 inhibitor
111in chx-a dtpa trastuzumabInhibitorexperimentalmAbERBB2 inhibitor
68ganota-anti-her2 vhh1InhibitorexperimentalmAbERBB2 inhibitor
99m-tc-nm-02InhibitorexperimentalmAbERBB2 inhibitor
99mtc-hpark2InhibitorexperimentalmAbERBB2 inhibitor
99mtc-mirc208InhibitorexperimentalmAbERBB2 inhibitor
a166InhibitorexperimentalmAbERBB2 inhibitor
adct-502InhibitorexperimentalmAbERBB2 inhibitor
aee-788InhibitorexperimentalSmall moleculeERBB2 inhibitor
afatinib (gilotrif)InhibitorapprovedSmall moleculeERBB2 inhibitor
aip-303InhibitorexperimentalmAbERBB2 inhibitor
allitinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
alt-p7InhibitorexperimentalmAbERBB2 inhibitor
amx 818InhibitorexperimentalRecombinant proteinERBB2 inhibitor
ANSUVIMAB (Ebanga)InhibitorapprovedmAbERBB2 inhibitor
ap32788InhibitorexperimentalSmall moleculeERBB2 inhibitor
ap402InhibitorexperimentalmAbERBB2 inhibitor
aro-dm1InhibitorexperimentalmAbERBB2 inhibitor
arx788InhibitorexperimentalmAbERBB2 inhibitor
av-412InhibitorexperimentalSmall moleculeERBB2 inhibitor
azd0754InhibitorexperimentalmAbERBB2 inhibitor
b002InhibitorexperimentalmAbERBB2 inhibitor
B003InhibitorexperimentalmAbERBB2 inhibitor
bat8001InhibitorexperimentalmAbERBB2 inhibitor
bb-1701InhibitorexperimentalmAbERBB2 inhibitor
bcd-147InhibitorexperimentalmAbERBB2 inhibitor
bdc-1001InhibitorexperimentalmAbERBB2 inhibitor
bebt-209InhibitorexperimentalSmall moleculeERBB2 inhibitor
bi-con-02InhibitorexperimentalmAbERBB2 inhibitor
bl-m17d1InhibitorexperimentalSmall moleculeERBB2 inhibitor
bms-599626InhibitorexperimentalSmall moleculeERBB2 inhibitor
bms-690514InhibitorexperimentalSmall moleculeERBB2 inhibitor
bnt323InhibitorexperimentalmAbERBB2 inhibitor
btrc4017aInhibitorexperimentalmAbERBB2 inhibitor
cam-h2InhibitorexperimentalmAbERBB2 inhibitor
canertinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
cct303-406InhibitorexperimentalCell therapyERBB2 inhibitor
cgt4255InhibitorexperimentalSmall moleculeERBB2 inhibitor
clio-8221InhibitorexperimentalmAbERBB2 inhibitor
coprelotamabInhibitorexperimentalmAbERBB2 inhibitor
cp-724714InhibitorexperimentalSmall moleculeERBB2 inhibitor
ct-p6InhibitorexperimentalSmall moleculeERBB2 inhibitor
cu64 trastuzumabInhibitorexperimentalmAbERBB2 inhibitor
cudc-101InhibitorexperimentalSmall moleculeERBB2 inhibitor
d3l-001InhibitorexperimentalmAbERBB2 inhibitor
dacomitinib (vizimpro)InhibitorapprovedSmall moleculeERBB2 inhibitor
db-1303InhibitorexperimentalmAbERBB2 inhibitor
dhes0815aInhibitorexperimentalmAbERBB2 inhibitor
DP303cInhibitorexperimentalmAbERBB2 inhibitor
dzd1516InhibitorexperimentalSmall moleculeERBB2 inhibitor
fcn-411InhibitorexperimentalSmall moleculeERBB2 inhibitor
fda022InhibitorexperimentalmAbERBB2 inhibitor
fda022-bb05InhibitorexperimentalmAbERBB2 inhibitor
fs-1502InhibitorexperimentalmAbERBB2 inhibitor
fs102InhibitorexperimentalmAbERBB2 inhibitor
ga-68labeled f(ab') 2- trastuzumabInhibitorexperimentalmAbERBB2 inhibitor
gensci139InhibitorexperimentalmAbERBB2 inhibitor
gq1001InhibitorexperimentalmAbERBB2 inhibitor
hemay-022InhibitorexperimentalSmall moleculeERBB2 inhibitor
hf50InhibitorexperimentalmAbERBB2 inhibitor
hki-357InhibitorexperimentalSmall moleculeERBB2 inhibitor
hlx22InhibitorexperimentalmAbERBB2 inhibitor
hlx87InhibitorexperimentalmAbERBB2 inhibitor
hmpl-a251InhibitorexperimentalmAbERBB2 inhibitor
hx22InhibitorexperimentalmAbERBB2 inhibitor
iah0968InhibitorexperimentalmAbERBB2 inhibitor
iam1363InhibitorexperimentalSmall moleculeERBB2 inhibitor
ibi315InhibitorexperimentalmAbERBB2 inhibitor
iks014InhibitorexperimentalmAbERBB2 inhibitor
isb 1302InhibitorexperimentalmAbERBB2 inhibitor
jnj-26483327InhibitorexperimentalSmall moleculeERBB2 inhibitor
jskn033InhibitorexperimentalmAbERBB2 inhibitor
kj015InhibitorexperimentalmAbERBB2 inhibitor
km501InhibitorexperimentalmAbERBB2 inhibitor
kn026InhibitorexperimentalmAbERBB2 inhibitor
ksp-910638gInhibitorexperimentalPeptideERBB2 inhibitor
ksp-qrh-e3-irdye800InhibitorexperimentalPeptideERBB2 inhibitor
lapatinib (tykerb)InhibitorapprovedSmall moleculeERBB2 inhibitor
lp-001InhibitorexperimentalmAbERBB2 inhibitor
m802InhibitorexperimentalmAbERBB2 inhibitor
margetuximab (Margenza)InhibitorapprovedmAbERBB2 inhibitor
masoprocol (actinex)InhibitorapprovedSmall moleculeERBB2 inhibitor
mbs301InhibitorexperimentalmAbERBB2 inhibitor
mdx-210InhibitorexperimentalmAbERBB2 inhibitor
medi4276InhibitorexperimentalmAbERBB2 inhibitor
mm-111InhibitorexperimentalmAbERBB2 inhibitor
mm-302InhibitorexperimentalmAbERBB2 inhibitor
mp0274InhibitorexperimentalRecombinant proteinERBB2 inhibitor
mrg002InhibitorexperimentalmAbERBB2 inhibitor
mt-5111InhibitorexperimentalRecombinant proteinERBB2 inhibitor
mubritinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
neratinib maleate (nerlynx)InhibitorapprovedSmall moleculeReceptor protein-tyrosine kinase erbB-2 inhibitor
njh395InhibitorexperimentalmAbERBB2 inhibitor
nvl-330InhibitorexperimentalSmall moleculeERBB2 inhibitor
oric-114InhibitorexperimentalSmall moleculeERBB2 inhibitor
orm-5029InhibitorexperimentalmAbERBB2 inhibitor
pertuzumab (perjeta)InhibitorapprovedmAbERBB2 inhibitor
pf-06804103InhibitorexperimentalmAbERBB2 inhibitor
pirotinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
prs-343InhibitorexperimentalmAbERBB2 inhibitor
pyrotinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
pyrrolitinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
s-222611InhibitorexperimentalSmall moleculeERBB2 inhibitor
sapitinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
selatinib ditosilateInhibitorexperimentalSmall moleculeERBB2 inhibitor
shr-4602InhibitorexperimentalSmall moleculeERBB2 inhibitor
shr-a1811InhibitorexperimentalmAbERBB2 inhibitor
sibp-a17InhibitorexperimentalmAbERBB2 inhibitor
syd985InhibitorexperimentalmAbERBB2 inhibitor
sym013InhibitorexperimentalmAbERBB2 inhibitor
sys6045InhibitorexperimentalmAbERBB2 inhibitor
tak285InhibitorexperimentalSmall moleculeERBB2 inhibitor
tarloxotinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
tas0728InhibitorexperimentalSmall moleculeERBB2 inhibitor
tas2940InhibitorexperimentalSmall moleculeERBB2 inhibitor
tesevatinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
trasgexInhibitorexperimentalmAbERBB2 inhibitor
trastuzumab (herceptin)InhibitorapprovedmAbERBB2 inhibitor
trastuzumab emtansine (kadcyla)InhibitorapprovedmAbERBB2 inhibitor
trastuzumab rezetecanInhibitorexperimentalmAbERBB2 inhibitor
tucatinib (Tukysa)InhibitorapprovedSmall moleculeERBB2 inhibitor
TuxobertinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
varlitinibInhibitorexperimentalSmall moleculeERBB2 inhibitor
vnx-202InhibitorexperimentalmAbERBB2 inhibitor
vrn101099InhibitorexperimentalSmall moleculeERBB2 inhibitor
xmt-1522InhibitorexperimentalmAbERBB2 inhibitor
ZanidatamabInhibitorapprovedmAbReceptor protein-tyrosine kinase erbB-2 inhibitor
zenocutuzumab (Bizengri)InhibitorapprovedmAbERBB2 inhibitor
zn-a-1041InhibitorexperimentalSmall moleculeERBB2 inhibitor
zongertinib (Hernexeos)InhibitorapprovedSmall moleculeERBB2 inhibitor
zw49InhibitorexperimentalmAbERBB2 inhibitor
gq1005ModulatorexperimentalSmall moleculeERBB2 modulator
TuxobertinibNegative allosteric modulatorexperimentalSmall moleculeReceptor protein-tyrosine kinase erbB-2 negative allosteric modulator
mdx-210OtherexperimentalmAbERBB2 other
[225ac]-fpi-2068RadiodepletionexperimentalSmall moleculeERBB2 radiodepletion
lu-aby-271RadiodepletionexperimentalmAbERBB2 radiodepletion
[111in]in-dota-tco-trastuzumabRadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical
[18f]f-resca-rb14RadiopharmaceuticalexperimentalSmall moleculeERBB2 radiopharmaceutical
[18f]f-resca-t4RadiopharmaceuticalexperimentalSmall moleculeERBB2 radiopharmaceutical
177lu-dfc413RadiopharmaceuticalexperimentalPeptideERBB2 radiopharmaceutical
68ga aby-025RadiopharmaceuticalexperimentalSmall moleculeERBB2 radiopharmaceutical
89zr-lncab002RadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical
89zr-lncab072RadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical
89zr-lncab103RadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical
89zr-lncab104RadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical
89zr-lncab190RadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical
tc-zher2:4107RadiopharmaceuticalexperimentalmAbERBB2 radiopharmaceutical