← Mechanisms of action
OPRK1
SINGLE PROTEINHomo sapiens
Preferred name: Kappa opioid receptor ChEMBL ↗
Linked proteins
Drugs acting on this target (35)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| anileridine (leritine) | Agonist | approved | Small molecule | OPRK1 agonist |
| Anrikefon | Agonist | experimental | Small molecule | OPRK1 agonist |
| asimadoline | Agonist | experimental | Small molecule | OPRK1 agonist |
| axomadol | Agonist | experimental | Small molecule | OPRK1 agonist |
| buprenorphine | Agonist | approved | Small molecule | OPRK1 agonist |
| difelikefalin (Korsuva) | Agonist | approved | Small molecule | OPRK1 agonist |
| dynorphin 1-13 | Agonist | experimental | Peptide | OPRK1 agonist |
| gic-1002 | Agonist | experimental | Small molecule | OPRK1 agonist |
| heroin | Agonist | experimental | Small molecule | OPRK1 agonist |
| ketobemidone (Ketogan) | Agonist | experimental | Small molecule | OPRK1 agonist |
| lt5001 | Agonist | experimental | Small molecule | OPRK1 agonist |
| nalbuphine (nubain) | Agonist | approved | Small molecule | OPRK1 agonist |
| orp-101 | Agonist | experimental | Small molecule | OPRK1 agonist |
| salvinorin a | Agonist | experimental | Small molecule | OPRK1 agonist |
| shr0410 | Agonist | experimental | Small molecule | OPRK1 agonist |
| spiradoline | Agonist | experimental | Small molecule | OPRK1 agonist |
| Thienorphine | Agonist | experimental | Small molecule | OPRK1 agonist |
| winfuran | Agonist | experimental | Small molecule | OPRK1 agonist |
| wol071-007 | Agonist | experimental | Small molecule | OPRK1 agonist |
| Aticaprant | Antagonist | experimental | Small molecule | Kappa opioid receptor antagonist |
| btrx-335140 | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| cerc-501 | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| cvl-354 | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| dezocine (dalgan) | Antagonist | approved | Small molecule | OPRK1 antagonist |
| jdtic | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| ly2456302 | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| ly2795050 | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| naloxol | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| orp-101 | Antagonist | experimental | Small molecule | Kappa opioid receptor antagonist |
| pf4455242 | Antagonist | experimental | Small molecule | OPRK1 antagonist |
| butorphanol (stadol) | Partial agonist | approved | Small molecule | OPRK1 partial agonist |
| kur-101 | Partial agonist | experimental | Small molecule | OPRK1 partial agonist |
| levallorphan (lorfan) | Partial agonist | approved | Small molecule | OPRK1 partial agonist |
| samidorphan (Lybalvi) | Partial agonist | approved | Small molecule | Kappa opioid receptor partial agonist |
| sebacoyl dinalbuphine ester (Naldebain) | Partial agonist | experimental | Small molecule | OPRK1 partial agonist |