asimadoline
Small moleculeexperimental
Asimadoline (EMD-61753) is an experimental drug which acts as a peripherally selective κ-opioid receptor (KOR) agonist. Because of its low penetration across the blood–brain barrier, asimadoline lacks the psychotomimetic effects of centrally acting KOR agonists, and consequently was thought to have potential for medical use. It has been studied as a possible treatment for irritable bowel syndrome, with reasonable efficacy seen in clinical trials, but it has never been approved or marketed. — Wikipedia
Clinical trial activity
6 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
5
Phase 3
1
Phase 4
0
Earliest trial started Jan 1, 2005 (NCT00955994)
Timeline
Indications
Mechanism of action
- Kappa opioid receptorAGONIST
OPRK1 agonist
Chemistry & pharmacology
Loading structure…
SMILES
CN(C(=O)C(c1ccccc1)c1ccccc1)[C@H](CN1CC[C@H](O)C1)c1ccccc1- Mol. weight
- 414.55 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAsimadoline ↗
- ChEMBLCHEMBL1190199 ↗
Also known as
- asimadoline
- asimadoline
- asimadoline
- asimadoline
- asimadoline
- emd 61753
- emd 61 753
- emd-61753
- emd-61753
- emd-61753
- emd-61 753
- n-methyl-n--(1-phenyl-2-(3-hydroxypyrrolidin-1-yl)ethyl)-2,2-diphenylacetamide hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02475447 | Phase 2 | Jul 1, 2015 | Tioga Pharmaceuticals |
| NCT01380561 | Phase 1 | Jun 1, 2011 | IQVIA, Tioga Pharmaceuticals |
| NCT01100684 | Phase 3 | May 1, 2010 | RTI Health Solutions, Tioga Pharmaceuticals |
| NCT00443040 | Phase 2 | Jan 1, 2007 | RTI Health Solutions, Tioga Pharmaceuticals |
| NCT00454688 | Phase 2 | Aug 1, 2006 | RTI Health Solutions, Tioga Pharmaceuticals |
| NCT00955994 | Phase 2 | Jan 1, 2005 | Mayo Clinic |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Tioga Pharmaceuticals | For profit | 5 | 5 | 3 | 2006 |
| RTI Health Solutions | For profit | 3 | 0 | 2 | 2006 |
| IQVIA | For profit | 1 | 0 | 1 | 2011 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2005 |
4 organizations
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