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hyaluronic acid

Small moleculeexperimental

Hyaluronic acid, also called hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans as it is non-sulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large: human synovial HA averages about 7 MDa per molecule, or about 20,000 disaccharide monomers, while other sources mention 3–4 MDa. — Wikipedia

Clinical trial activity

528 trials · 434 clinical orgs · 0 marketing orgs

Phase 1
72
Phase 2
157
Phase 3
91
Phase 4
121

Earliest trial started Oct 1, 1998 (NCT02197026)

Timeline

2000s

  1. Jan 1, 2002

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@@H]1C(=O)O
Mol. weight
381.33 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
Yes

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • am 111
  • am-111
  • am-111
  • am-111
  • am111 peptide
  • da-5202
  • d-jnki1
  • d-jnki-1
  • emervel
  • hmw-ha
  • hyaluronan
  • hyaluronan
  • hyaluronan
  • hyaluronate
  • hyaluronate
  • hyaluronate
  • hyaluronate sodium
  • hyaluronate sodium
  • hyaluronate sodium
  • hyaluronate sodium
  • hyaluronate sodium
  • hyaluronate sodium
  • hyaluronate sodium
  • hyaluronic acid
  • hyaluronic acid
  • hyaluronic acid
  • hyaluronic acid
  • hyaluronic acid
  • hylan gf-20
  • hylan g-f 20 (gz/sar402662)
  • jta-004
  • lbsa0103
  • legend
  • legend
  • osteopontin
  • restylane
  • sodium hyaluronate
  • sodium hyaluronate
  • syndecan-1
  • xg 102
  • xg-102
  • xg-102
  • xg-102
  • xg102 peptide
  • yyd302

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07082270Phase 1Feb 1, 2026State University of New York, Buffalo
NCT07202390N/AFeb 1, 2026Aalborg University, Government of Denmark
NCT07280442Phase 4Jan 8, 2026Universidad Complutense de Madrid
NCT07265791N/AJan 3, 2026Jetema USA Inc.
NCT07305519N/AJan 1, 2026University of Roma La Sapienza
NCT07236632N/ADec 15, 2025Benha University
NCT07205640N/ADec 1, 2025Cairo University
NCT07219654Phase 2Nov 30, 2025Tego Science, Inc.
NCT07280507Early Phase 1 (Phase 1)Nov 24, 2025King Abdul-Aziz University
NCT06948084Phase 2Oct 31, 2025ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
NCT07012525Phase 1/Phase 2 (Phase 2)Sep 15, 2025Dar Al Uloom University
NCT07121439N/ASep 15, 2025University of Indonesia
NCT07031895N/ASep 2, 2025Erciyes University
NCT07097922N/AAug 1, 2025He Eye Hospital
NCT07102186Phase 4Jul 21, 2025Badr University
NCT07081230N/AJul 7, 2025Mansoura University
NCT07031388N/AJul 1, 2025Kurdistan Board for Medical Specialist
NCT07291583N/AJul 1, 2025Saglik Bilimleri Universitesi
NCT06818487N/AJul 1, 2025Capital Medical University
NCT07309588Phase 1/Phase 2 (Phase 2)Jul 1, 2025Poznan University
Showing 20 of 528 trials
Page 1 / 27

Organizations

Research & Development (434)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Cairo UniversityAcademic/Hospital131342016
Laboratorios Sophia S.A de C.V.For profit8832015
Shin Kong Wu Ho-Su Memorial HospitalAcademic/Hospital8322014
Taipei Veteran General hospitalGovernment8732012
Assiut UniversityAcademic/Hospital7742016
Chang Gung UniversityAcademic/Hospital7542015
Jiao Tong UniversityAcademic/Hospital7432014
Kaohsiung Medical UniversityAcademic/Hospital7542007
Nakhia Impex LLCFor profit7612020
SanofiFor profit7422002
Ain Shams UniversityAcademic/Hospital6632019
Alexandria UniversityAcademic/Hospital6622019
AllerganFor profit6512007
GenzymeFor profit6332006
Mansoura UniversityAcademic/Hospital6522016
Sungkyunkwan UniversityAcademic/Hospital6442014
Taipei Medical UniversityAcademic/Hospital6622015
University of IndonesiaAcademic/Hospital6642012
University of Sao PauloAcademic/Hospital6632009
Capital Medical UniversityAcademic/Hospital5532020
434 organizations
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