← Mechanisms of action
JAK1
SINGLE PROTEINHomo sapiens
Preferred name: Tyrosine-protein kinase JAK1 ChEMBL ↗
Linked proteins
Drugs acting on this target (41)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| benzylpenicillin | Antagonist | approved | Small molecule | JAK1 antagonist |
| pf-07259955 | Antagonist | experimental | Small molecule | JAK1 antagonist |
| pf-07295324 | Antagonist | experimental | Small molecule | JAK1 antagonist |
| bidridistrogene xeboparvovec | Antisense inhibitor | experimental | Nucleic acid | JAK1 antisense inhibitor |
| na-apr-1 | Immunity, active | experimental | Vaccine | JAK1 immunity, active |
| na-gst-1 | Immunity, active | experimental | Vaccine | JAK1 immunity, active |
| agar t cells | Immunity, passive | experimental | Cell therapy | JAK1 immunity, passive |
| abrocitinib (Cibinqo) | Inhibitor | approved | Small molecule | Tyrosine-protein kinase JAK1 inhibitor |
| ati-50002 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| ati-501 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| baricitinib (olumiant) | Inhibitor | approved | Small molecule | JAK1 inhibitor |
| bhv-8000 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| Brepocitinib | Inhibitor | experimental | Small molecule | Tyrosine-protein kinase JAK1 inhibitor |
| cerdulatinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| delgocitinib (Anzupgo) | Inhibitor | approved | Small molecule | JAK1 inhibitor |
| deuruxolitinib | Inhibitor | approved | Small molecule | JAK1 inhibitor |
| env-294 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| filgotinib (Jyseleca) | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| glpg-0555 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| golidocitinib | Inhibitor | experimental | Small molecule | Tyrosine-protein kinase JAK1 inhibitor |
| incb047986 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| itacitinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| Ivarmacitinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| Izencitinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| jaktinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| lnk01004 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| lw402 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| momelotinib (Ojjaara) | Inhibitor | approved | Small molecule | JAK1 inhibitor |
| pf-04965842 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| Povorcitinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| Pumecitinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| r932333 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| ruxolitinib (jakafi) | Inhibitor | approved | Small molecule | JAK1 inhibitor |
| solcitinib | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| tll-018 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| tricetamide | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| vr588 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| vvn432 | Inhibitor | experimental | Small molecule | JAK1 inhibitor |
| hyaluronic acid | Other | experimental | Small molecule | JAK1 other |
| polysorbate 80 | Other | experimental | Small molecule | JAK1 other |
| ata-200 | Supplementation | experimental | Gene therapy | JAK1 supplementation |