tandutinib
Small moleculeexperimental
Clinical trial activity
8 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2002 (NCT00064584)
Timeline
Indications
Studied for
Mechanism of action
PDGFRB inhibitor
- Stem cell growth factor receptorINHIBITOR
KIT inhibitor
FLT3 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1- Mol. weight
- 562.72 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL124660 ↗
Also known as
- 4-(6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide
- ct53518
- ct53518
- ct53518
- ct 53518
- ct-53518
- ct-53518
- ct-53518
- mln-0518
- mln-0518
- mln518
- mln518
- mln518
- mln 518
- mln-518
- mln-518
- mln-518
- tandutinib
- tandutinib
- tandutinib
- tandutinib
- tandutinib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00904852 | Phase 1 | Jun 1, 2009 | Millennium Pharmaceuticals |
| NCT00667394 | Phase 2 | Apr 1, 2008 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
| NCT00379080 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2007 | National Cancer Institute (NCI) |
| NCT00408902 | Phase 2 | Nov 1, 2006 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00390468 | Phase 2 | Oct 1, 2006 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT00297921 | Phase 1/Phase 2 (Phase 2) | Feb 27, 2006 | Millennium Pharmaceuticals |
| NCT00274248 | Phase 1 | Mar 1, 2005 | Millennium Pharmaceuticals |
| NCT00064584 | Phase 1 | May 1, 2002 | Millennium Pharmaceuticals |
Showing 8 of 8 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Millennium Pharmaceuticals | For profit | 4 | 4 | 2 | 2002 |
| National Cancer Institute (NCI) | Government | 4 | 4 | 1 | 2006 |
| Case Western Reserve University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2008 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2006 |
5 organizations
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