CDEK
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mepivacaine

Trade name: carbocaine

Small moleculeapproved

Approved

Jan 6, 1960

Dexivacaine is a local anesthetic drug that has minimal and non-significant side effects. — NCATS

Clinical trial activity

68 trials · 58 clinical orgs · 10 marketing orgs

Phase 1
4
Phase 2
10
Phase 3
8
Phase 4
28

Earliest trial started May 1, 2007 (NCT01032798)

Timeline

1960s

  1. Jan 6, 1960

    Kodak — Earliest FDA Approval

  2. Jan 6, 1960

    Kodak — NDA Secondary Org

  3. Jan 6, 1960

    Kodak — NDA Organization

  4. May 17, 1960

    Hospira — NDA Secondary Org

1970s

  1. Oct 17, 1972

    Septodont — Marketing Organization

  2. Dec 4, 1973

    Belmora — Marketing Organization

  3. Dec 17, 1975

    Solvay — Marketing Organization

1980s

  1. Oct 5, 1982

    International Medication — Marketing Organization

  2. Aug 21, 1984

    Dentsply International — Marketing Organization

  3. Oct 10, 1984

    Deproco — Marketing Organization

  4. Nov 20, 1984

    Watson Pharmaceuticals — Marketing Organization

  5. Dec 1, 1986

    Fresenius — Marketing Organization

2000s

  1. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

  3. Apr 28, 2008

    Hospira — Marketing Organization

2010s

  1. Jan 1, 2018

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Combination products

  • carbocaine w/ neo-cobefrin

    with levonordefrin

    Also known as arestocaine hydrochloride w/ levonordefrin, isocaine hydrochloride w/ levonordefrin, polocaine w/ levonordefrin, scandonest l

Approval history

  • approvedPriority reviewJan 6, 1960

Chemistry & pharmacology

Loading structure…

SMILES

Cc1cccc(C)c1NC(=O)C1CCCCN1C
Mol. weight
246.35 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • (+-)-1-methyl-2',6'-pipecoloxylidide
  • (+-)-1-methyl-2',6'-pipecoloxylidide
  • 1-methyl-2',6'-pipecoloxylidide
  • 1-methyl-2',6'-pipecoloxylidide
  • arestocaine hcl
  • arestocaine hcl
  • carbocain
  • carbocaine
  • carbocaine
  • carbocaine
  • carbocaine
  • dl-mepivacaine
  • dl-mepivacaine
  • dl-mepivacaine
  • isocaine hcl
  • isocaine hcl
  • mepicaine
  • mepivacaina
  • mepivacaina
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • mepivacaine
  • (+/-)-mepivacaine
  • mepivacaine hcl
  • mepivacaine hcl
  • mepivacaine hcl
  • mepivacaine hydrochloride
  • mepivacaine hydrochloride
  • mepivacaine hydrochloride
  • mepivacaine hydrochloride
  • mepivacainum
  • mepivacainum
  • mepivicaine
  • mepivicaine
  • n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide
  • n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide
  • n-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide
  • n-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide
  • polocaine
  • polocaine
  • polocaine-mpf
  • polocaine-mpf
  • scandicaine
  • scandicaine
  • scandonest
  • scandonest
  • scandonest plain
  • scandonest plain
  • tevacaine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07239999Phase 4Jan 12, 2026Dalhousie University, Government of Canada
NCT07298746N/ADec 31, 2025Sohag University
NCT06927726N/AJan 10, 2025Tanta University
NCT06710704N/AApr 1, 2024Tanta University
NCT06291727Phase 4Feb 16, 2024Prisma Health
NCT07013071Phase 4Feb 10, 2024King Abdul-Aziz University
NCT06172400N/AJan 9, 2024Region Skane
NCT06047366Phase 4Dec 5, 2023Indiana University, United States Army
NCT05425979Phase 4Nov 30, 2023Mayo Clinic
NCT06128590N/ANov 15, 2023University of Nove de Julho
NCT06005480Phase 1Sep 30, 2023Harvard University
NCT05980546Phase 4Jun 7, 2023Rockefeller University
NCT05839548Phase 3Jun 1, 2023Qassim Health Cluster, Qassim University
NCT05875519N/AMay 1, 2023Minia University
NCT05728151N/AFeb 12, 2023Research Institute of Ophthalmology, Egypt
NCT05222828Phase 2Jun 22, 2022Assistance Publique - Hôpitaux de Paris
NCT05338983N/AMay 1, 2022Mansoura University
NCT05238727N/AMar 31, 2022Cairo University
NCT05201313Phase 3Jan 20, 2022University of Udine
NCT05083975N/ADec 31, 2021Cairo University
Showing 20 of 68 trials
Page 1 / 4

Organizations

Research & Development (58)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Cairo UniversityAcademic/Hospital101032014
Rockefeller UniversityAcademic/Hospital4432012
University of Sao PauloAcademic/Hospital3322007
ASST Gaetano Pini-CTOAcademic/Hospital2212014
Duke UniversityAcademic/Hospital2212018
Harvard UniversityAcademic/Hospital2212020
Mayo ClinicAcademic/Hospital2222019
Tanta UniversityAcademic/Hospital2212024
University of TorontoAcademic/Hospital2212008
Vanderbilt UniversityAcademic/Hospital2212015
Alexandria UniversityAcademic/Hospital1112018
Assistance Publique - Hôpitaux de ParisAcademic/Hospital1112022
Beni Suef UniversityAcademic/Hospital1012016
Campus Bio-Medico UniversityAcademic/Hospital1112012
Centre Hospitalier de la Région d'AnnecyAcademic/Hospital1112012
CitospinFor profit1012013
Complexo Hospitalario Universitario de A CoruñaAcademic/Hospital1112016
Dalhousie UniversityAcademic/Hospital1012026
Dow University of Health SciencesAcademic/Hospital1112018
Fluminense Federal UniversityAcademic/Hospital1112010
58 organizations
Page 1 / 3

Marketing (13)

OrganizationOrg typeRelationshipDate
BelmoraAcademic/HospitalMKTGDec 4, 1973
Dentsply InternationalFor profitMKTGAug 21, 1984
DeprocoFor profitMKTGOct 10, 1984
FreseniusFor profitMKTGDec 1, 1986
HospiraFor profitNDA2May 17, 1960
HospiraFor profitMKTGApr 28, 2008
International MedicationFor profitMKTGOct 5, 1982
KodakFor profitNDA2Jan 6, 1960
KodakFor profitNDAJan 6, 1960
SeptodontFor profitSYNOct 17, 1972
SeptodontFor profitMKTGOct 17, 1972
SolvayFor profitMKTGDec 17, 1975
Watson PharmaceuticalsFor profitMKTGNov 20, 1984