levonordefrin
Trade name: Neo-Cobefrine
Approved
Sep 19, 1952
Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It is administered in a pre-mixed solution with local anesthetics, such as mepivacaine or procaine. — NCATS
Clinical trial activity
3 trials · 2 clinical orgs · 6 marketing orgs
Earliest trial started Oct 22, 2020 (NCT04561921)
Timeline
1960s
- Jan 6, 1960
Kodak — NDA Secondary Org
1970s
1980s
- Oct 10, 1984
Deproco — Marketing Organization
- Apr 14, 1988
Dentsply International — Marketing Organization
2020s
- Jan 1, 2020
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
Combination products
carbocaine w/ neo-cobefrin
with mepivacaine
Also known as arestocaine hydrochloride w/ levonordefrin, isocaine hydrochloride w/ levonordefrin, polocaine w/ levonordefrin, scandonest l
ravocaine and novocain w/ neo-cobefrin
Approval history
- approvedSep 19, 1952
Chemistry & pharmacology
SMILES
C[C@H](N)[C@H](O)C1=CC=C(O)C(O)=C1- Mol. weight
- 183.2044 g/mol
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCorbadrine ↗
- NCATSV008L6478D ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05875519 | N/A | May 1, 2023 | Minia University |
| NCT04477317 | Phase 3 | Nov 30, 2020 | Cairo University |
| NCT04561921 | N/A | Oct 22, 2020 | Cairo University |
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 2 | 2 | 2 | 2020 |
| Minia University | Academic/Hospital | 1 | 1 | 1 | 2023 |
Marketing (8)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Belmora | Academic/Hospital | MKTG | Jan 22, 1976 |
| Dentsply International | For profit | MKTG | Apr 14, 1988 |
| Deproco | For profit | MKTG | Oct 10, 1984 |
| Kodak | For profit | NDA2 | Jan 6, 1960 |
| Kodak | For profit | NDA | Sep 19, 1952 |
| Septodont | For profit | MKTG | Feb 6, 1976 |
| Septodont | For profit | SYN | Feb 6, 1976 |
| Solvay | For profit | MKTG | Apr 15, 1976 |