epidermal growth factor
Recombinant proteinexperimental
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has 53 amino acid residues and three intramolecular disulfide bonds. — Wikipedia
Clinical trial activity
24 trials · 24 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
7
Phase 3
7
Phase 4
1
Earliest trial started May 1, 2007 (NCT00460265)
Timeline
Indications
Approved for
Studied for
- Anesthesia · Phase 1
- Burns · Phase 2/Phase 3
- Carcinoma, Mucoepidermoid · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2/Phase 3
- Colorectal Neoplasms · Phase 2/Phase 3
- Diabetes Mellitus · Phase 3
- Diabetic Foot · Phase 3
- Dry Eye Syndromes · Phase 1
- Epidermal Growth Factor · Phase 3
- Glaucoma · Phase 1
- Graft vs Host Disease · Phase 1
- Mesenchymal Stem Cell Transplantation · Phase 1
- Ocular Hypertension · Phase 1
- Pancreatic Neoplasms · Phase 2/Phase 3
- Periodontitis · Phase 1
- Psoriasis · Phase 1
- Squamous Cell Carcinoma of Head and Neck · Phase 3
- Stomatitis · Phase 3
- Temporomandibular Joint Disorders · Phase 4
- Tongue Neoplasms · Phase 2
Mechanism of action
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaEpidermal growth factor ↗
Also known as
- egf
- egf
- epidermal growth factor
- epidermal growth factor
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05724589 | N/A | Jan 30, 2023 | Institute of Dermatology, Thailand |
| NCT06044974 | Phase 4 | Jan 21, 2023 | Alexandria University |
| NCT04995354 | Phase 2/Phase 3 (Phase 3) | Jun 1, 2022 | Cairo University |
| NCT04886726 | Phase 1 | Dec 1, 2021 | Henry Ford Health System |
| NCT04235296 | Phase 1 | Jan 17, 2020 | People's Liberation Army of China |
| NCT04375618 | Phase 1 | Oct 1, 2019 | SVS Institute of Dental Sciences |
| NCT05335720 | N/A | Jul 19, 2019 | Daewoong Pharmaceutical Co. LTD., Equilab International |
| NCT05219461 | Phase 1 | Mar 29, 2019 | Daewoong Pharmaceutical Co. LTD. |
| NCT04211597 | N/A | Sep 5, 2017 | Chang Gung University |
| NCT04704245 | N/A | Jul 20, 2017 | Catholic University of Korea, Hallym University |
| NCT02554851 | Phase 3 | Jan 1, 2017 | Oswaldo Cruz Foundation |
| NCT03047863 | N/A | Nov 1, 2016 | Catholic University of Korea |
| NCT03051880 | N/A | Nov 1, 2016 | Catholic University of Korea |
| NCT02748707 | Phase 2 | Aug 1, 2015 | Tata Memorial Hospital |
| NCT02284139 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2015 | Dong-A University |
| NCT01593995 | Phase 2 | May 1, 2012 | Dong-A University |
| NCT01566578 | Phase 1 | Apr 1, 2012 | Ennar Pharmaceuticals AF, University of Zurich |
| NCT01553708 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2011 | Chulalongkorn University, National Science and Technology Development Agency, Thailand |
| NCT01180062 | Phase 1 | Jan 1, 2011 | Pfizer, University of Kentucky, University of Toronto |
| NCT01308541 | Phase 1 | Jan 1, 2011 | Eisai |
Showing 20 of 24 trials
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Organizations
Research & Development (24)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Daewoong Pharmaceutical Co. LTD. | For profit | 5 | 4 | 4 | 2009 |
| Catholic University of Korea | Academic/Hospital | 3 | 2 | 1 | 2016 |
| Dong-A University | Academic/Hospital | 2 | 2 | 2 | 2012 |
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Amgen | For profit | 1 | 1 | 1 | 2007 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Chang Gung University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Chulalongkorn University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Eisai | For profit | 1 | 1 | 1 | 2011 |
| Ennar Pharmaceuticals AF | For profit | 1 | 1 | 1 | 2012 |
| Equilab International | For profit | 1 | 0 | 1 | 2019 |
| Hallym University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Henry Ford Health System | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Institute of Dermatology, Thailand | Academic/Hospital | 1 | 1 | 1 | 2023 |
| National Science and Technology Development Agency, Thailand | Government | 1 | 0 | 1 | 2011 |
| Oswaldo Cruz Foundation | Academic/Hospital | 1 | 1 | 1 | 2017 |
| People's Liberation Army of China | Government | 1 | 1 | 1 | 2020 |
| Pfizer | For profit | 1 | 0 | 1 | 2011 |
| Seoul National University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| SVS Institute of Dental Sciences | Academic/Hospital | 1 | 1 | 1 | 2019 |
24 organizations
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