zimeldine
Trade name: Normud
Approved
Jun 1, 1982
Zimelidine was one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants to be marketed. It is a pyridylallylamine, and is structurally different from other antidepressants. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Timeline
1980s
- Jun 1, 1982
Earliest FDA Approval
Indications
Approved for
Mechanism of action
- Serotonin (5-HT) receptorANTAGONIST
Serotonin (5-HT) receptor antagonist
Zimelidine (ZIM) and its main active metabolite norzimelidine (NZIM) have been shown to preferentially inhibit 5-hydroxytryptamine (5-HT, serotonin) neuronal uptake both in vitro and in vivo while having much less effect on noradrenaline (NA) uptake. ZIM in vivo blocked the 5-HT uptake mechanism in the cerebral cortex, hippocampus, striatum, hypothalamus and spinal cord, thus indicating effects on both the ascending and descending 5-HT pathways. ZIM is devoid of a 5-HT releasing action, MAO-inhibitory properties and effects on dopamine (DA) uptake
- 5-hydroxytryptamine receptor 1F (HTR1F) ↗
- 5-hydroxytryptamine receptor 2B (HTR2B) ↗
- 5-hydroxytryptamine receptor 4 (HTR4) ↗
- 5-hydroxytryptamine receptor 1B (HTR1B) ↗
- 5-hydroxytryptamine receptor 3A (HTR3A) ↗
- 5-hydroxytryptamine receptor 1A (HTR1A) ↗
- 5-hydroxytryptamine receptor 1D (HTR1D) ↗
- 5-hydroxytryptamine receptor 2A (HTR2A) ↗
- 5-hydroxytryptamine receptor 2C (HTR2C) ↗
- 5-hydroxytryptamine receptor 1E (HTR1E) ↗
- 5-hydroxytryptamine receptor 7 (HTR7) ↗
- 5-hydroxytryptamine receptor 6 (HTR6) ↗
- 5-hydroxytryptamine receptor 5A (HTR5A) ↗
- 5-hydroxytryptamine receptor 3E (HTR3E) ↗
- 5-hydroxytryptamine receptor 3B (HTR3B) ↗
- 5-hydroxytryptamine receptor 3D (HTR3D) ↗
- 5-hydroxytryptamine receptor 3C (HTR3C) ↗
- Serotonin 1a (5-HT1a) receptor
- Serotonin 1d (5-HT1d) receptor
- Serotonin 1b (5-HT1b) receptor
- Serotonin 2a (5-HT2a) receptor
- Serotonin 2c (5-HT2c) receptor
- Serotonin 3a (5-HT3a) receptor
- Serotonin 4 (5-HT4) receptor
- Serotonin 2b (5-HT2b) receptor
- Serotonin 1f (5-HT1f) receptor
- Serotonin 7 (5-HT7) receptor
- Serotonin 1e (5-HT1e) receptor
- Serotonin 5a (5-HT5a) receptor
- Serotonin 6 (5-HT6) receptor
- Serotonin 3 (5-HT3) receptor
- Serotonin 2 (5-HT2) receptor
- Serotonin 1 receptors; 5-HT1B & 5-HT1D
- Serotonin 2 receptors; 5-HT2a & 5-HT2c
- Serotonin receptor (2b and 2c)
- Serotonin 3 (5-HT3) receptor
- Serotonin 1 (5-HT1) receptor
- Serotonin 3b (5-HT3b) receptor
- 5-hydroxytryptamine receptor 3A/3E
- 5-hydroxytryptamine receptor 3A/3C
- 5-HT1A/5-HT1F
- 5-HT1D/5-HT1F
- 5-HT1B/5-HT1F
Approval history
- withdrawnJun 1, 1982
Chemistry & pharmacology
SMILES
CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1- Mol. weight
- 317.23 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL37744 ↗
- WikipediaZimelidine ↗
- ChEMBLCHEMBL2355333 ↗
- ChEMBLCHEMBL1257115 ↗
- ChEMBLCHEMBL1257002 ↗
Also known as
- cis-zimelidine
- cis-zimelidine
- cis-zimelidine
- h 102/09 hcl
- h 102/09 hcl
- normud
- normud
- (z)-3-[1-(p-bromophenyl)-3-(dimethylamino)propenyl]pyridine
- (z)-3-[1-(p-bromophenyl)-3-(dimethylamino)propenyl]pyridine
- (z)-3-(4'-bromophenyl)-3-(3''-pyridyl)dimethylallylamine
- (z)-3-(4'-bromophenyl)-3-(3''-pyridyl)dimethylallylamine
- zelmid
- zelmid
- zelmid
- zimeldine
- zimeldine
- zimeldine
- zimeldine
- zimeldine
- zimeldine
- zimeldine hcl
- zimeldine hcl
- zimeldine hydrochloride
- zimeldine hydrochloride
- zimeldine hydrochloride hydrate
- zimeldine hydrochloride hydrate
- zimeldine hydrochloride hydrate
- zimeldine hydrochloride hydrate
- zimeldine hydrochloride hydrate
- zimeldine hydrochloride hydrate
- zimelidine
- zimelidine
- zimelidine
- zimelidine
- zimelidine
- zimelidine dihydrochloride
- zimelidine dihydrochloride hydrate
- zimelidine dihydrochloride monohydrate
- zimelidine hcl
- zimelidine hcl
- zimelidine hcl
- zimelidine hydrochloride
- (z)-zimelidine
- (z)-zimelidine
Organizations
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Astra | For profit | NDA | — |