terodiline
Small moleculeexperimental
Terodiline is a drug used in urology as an antispasmodic. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 1 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Mechanism of action
- Muscarinic acetylcholine receptorANTAGONIST
Muscarinic acetylcholine receptor antagonist
Terodiline has non-selective anticholinergic and calcium blocking effects within the same concentration range, the anticholinergic effect predominating at low and the calcium entry blocking action at high concentrations.
- Muscarinic acetylcholine receptor M3 (CHRM3) ↗
- Muscarinic acetylcholine receptor M4 (CHRM4) ↗
- Muscarinic acetylcholine receptor M1 (CHRM1) ↗
- Muscarinic acetylcholine receptor M5 (CHRM5) ↗
- Muscarinic acetylcholine receptor M2 (CHRM2) ↗
- Muscarinic acetylcholine receptor M2
- Muscarinic acetylcholine receptor M1
- Muscarinic acetylcholine receptor M4
- Muscarinic acetylcholine receptor M5
- Muscarinic acetylcholine receptor M3
- Muscarinic acetylcholine receptors; M2 & M3
- Muscarinic acetylcholine receptors; M1 & M2
- Muscarinic acetylcholine receptor M1/M5 chimeric protein
- Muscarinic acetylcholine receptor M1 and M3
- Muscarinic acetylcholine receptor M2 and M4
- Muscarinic acetylcholine receptor M2 and M5
Voltage-gated calcium channel blocker
Terodiline has non-selective anticholinergic and calcium blocking effects within the same concentration range, the anticholinergic effect predominating at low and the calcium entry blocking action at high concentrations.
It was reported that the drug inhibits guinea-pig bladder L-type Ca2+ current (ICa,L) with an IC50 of 1.7 uM.
- Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D) ↗
- Voltage-dependent P/Q-type calcium channel subunit alpha-1A (CACNA1A) ↗
- Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) ↗
- Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G) ↗
- Voltage-dependent calcium channel subunit alpha-2/delta-4 (CACNA2D4) ↗
- Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I) ↗
- Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F) ↗
- Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) ↗
- Voltage-dependent L-type calcium channel subunit beta-3 (CACNB3) ↗
- Voltage-dependent calcium channel gamma-7 subunit (CACNG7) ↗
- Voltage-dependent calcium channel gamma-5 subunit (CACNG5) ↗
- Voltage-dependent calcium channel gamma-2 subunit (CACNG2) ↗
- Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) ↗
- Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) ↗
- Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) ↗
- Voltage-dependent calcium channel gamma-4 subunit (CACNG4) ↗
- Voltage-dependent calcium channel gamma-8 subunit (CACNG8) ↗
- Voltage-dependent calcium channel gamma-3 subunit (CACNG3) ↗
- Voltage-dependent calcium channel gamma-6 subunit (CACNG6) ↗
- Voltage-dependent calcium channel gamma-1 subunit (CACNG1) ↗
- Voltage-gated T-type calcium channel alpha-1H subunit
- Voltage-gated calcium channel alpha2/delta subunit 1
- Voltage-gated L-type calcium channel alpha-1C subunit
- Voltage-gated N-type calcium channel alpha-1B subunit
- Voltage-gated L-type calcium channel alpha-1S subunit
- Voltage-gated L-type calcium channel alpha-1D subunit
- Voltage-gated calcium channel alpha2/delta subunit 2
- Voltage-gated P/Q-type calcium channel alpha-1A subunit
- Voltage-gated T-type calcium channel alpha-1G subunit
- Voltage-gated T-type calcium channel alpha-1I subunit
- Voltage-dependent R-type calcium channel subunit alpha-1E
- Voltage-gated L-type calcium channel
- Voltage-gated T-type calcium channel
- Voltage-dependent L-type calcium channel subunit beta-2
- Voltage-dependent N-type calcium channel subunit alpha-1B/Voltage-dependent calcium channel subunit alpha-2/delta-1/Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b
- Voltage-dependent P/Q-type calcium channel alpha1A/alpha2delta/beta1b
- N-type calcium channel alpha-1b/alpha2delta-1/beta-1b
- L-type calcium channel alpha-1c/beta-2/alpha2delta-1
- Voltage-dependent L-type calcium channel subunit beta-3
- Voltage-dependent L-type calcium channel subunit alpha-1C/L-type calcium channel subunit beta-3/calcium channel subunit alpha-2/delta-1
Chemistry & pharmacology
Loading structure…
SMILES
CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C- Mol. weight
- 281.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL363295 ↗
- WikipediaTerodiline ↗
- ChEMBLCHEMBL539770 ↗
Also known as
- bicor
- bicor
- dl-terodiline
- micturin 12.5
- micturin 25
- n-tert-butyl-1-methyl-3,3-diphenylpropylamine
- n-tert-butyl-3,3-diphenyl-1-methylpropylamine
- td 758
- td-758
- terodiline
- terodiline
- terodiline
- terodiline
- terodiline
- terodiline
- terodiline
- terodiline
- terodiline hcl
- terodiline hcl
- terodiline hcl
- terodiline hydrochloride
- terodiline hydrochloride
- terodiline hydrochloride
- terodiline hydrochloride
Organizations
Marketing (1)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Pharmacia | For profit | NDA | — |