Dent Disease

X-linked recessive NEPHROLITHIASIS characterized by HYPERCALCIURIA; HYPOPHOSPHATEMIA; NEPHROCALCINOSIS; and PROTEINURIA. It is associated with mutations in the voltage-gated chloride channel, CLC-5 (Dent Disease I). Another group of mutations associated with this disease is in phosphatidylinositol 4,5-bisphosphate-5-phosphatase gene.

Drugs by status

Phase 3 trials (1)

hydrochlorothiazide

Phase 2 trials (1)

potassium phosphate

Organizations

Organization Involved with Phase 3 Indications (1)

University of Paris

Organization Involved with Phase 2 Indications (1)

Mayo Clinic