deserpidine
Trade name: harmonyl
Approved
Apr 19, 1957
Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. Rauwolfia alkaloids work by controlling nerve impulses along certain nerve pathways. As a result, they act on the heart and blood vessels to lower blood pressure. Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 3 marketing orgs
Timeline
Indications
Approved for
Mechanism of action
- Synaptic vesicular amine transporterINHIBITOR
SLC18A2 inhibitor
Combination products
enduronyl
with methyclothiazide
Also known as enduronyl forte
oreticyl forte
with hydrochlorothiazide
Also known as oreticyl
Approval history
- approvedApr 19, 1957
Chemistry & pharmacology
SMILES
CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C(NC5=C4C=CC=C5)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)C6=CC(OC)=C(OC)C(OC)=C6- Mol. weight
- 578.6527 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaDeserpidine ↗
- NCATS9016E3VB47 ↗
- ChEMBLCHEMBL1200515 ↗
Also known as
- 11-demethoxyreserpine
- 11-demethoxyreserpine
- 11-desmethoxyreserpine
- 11-desmethoxyreserpine
- (3beta,16beta,17alpha,18beta,20alpha)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
- (3beta,16beta,17alpha,18beta,20alpha)-17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
- canescine
- canescine
- deserpidin
- deserpidina
- deserpidina
- deserpidine
- deserpidine
- deserpidine
- deserpidine
- deserpidine
- deserpidine
- deserpidine
- deserpidine
- deserpidine
- deserpidinum
- deserpidinum
- harmonyl
- harmonyl
- harmonyl
- raunormin
- raunormine
- raunormine
- raunormine
- recanescin
- recanescin
- recanescin
- recanescine
- recanescine
- recanescine
- reserpidine
Organizations
Marketing (5)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| AbbVie | For profit | NDA2 | Apr 19, 1957 |
| AbbVie | For profit | NDA | Apr 19, 1957 |
| Abbott | For profit | MKTG | Aug 1, 1961 |
| Abbott | For profit | NDA2 | Aug 1, 1961 |
| Watson Pharmaceuticals | For profit | MKTG | — |