← Mechanisms of action
TOP1
SINGLE PROTEINHomo sapiens
Preferred name: DNA topoisomerase I ChEMBL ↗
Linked proteins
Drugs acting on this target (26)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| aclarubicin | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| becatecarin | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| belotecan | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| datopotamab deruxtecan (Datroway) | Inhibitor | approved | mAb | DNA topoisomerase I inhibitor |
| dfp-13318 | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| diflomotecan | Inhibitor | experimental | Small molecule | DNA topoisomerase I inhibitor |
| edotecarinum | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| elsamitrucin | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| esg206 | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| etirinotecan pegol (Onzeald) | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| exatecan | Inhibitor | experimental | Small molecule | DNA topoisomerase I inhibitor |
| fam-trastuzumab deruxtecan-nxki (Enhertu) | Inhibitor | approved | mAb | DNA topoisomerase I inhibitor |
| glyc-101 | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| irinotecan (Camptosar) | Inhibitor | approved | Small molecule | TOP1 inhibitor |
| karenitecin | Inhibitor | experimental | Small molecule | DNA topoisomerase I inhibitor |
| labetuzumab govitecan | Inhibitor | experimental | mAb | DNA topoisomerase 1 inhibitor |
| mureletecan | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| namitecan | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| nev801 | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| patritumab | Inhibitor | experimental | mAb | DNA topoisomerase I inhibitor |
| rubitecan | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| sacituzumab govitecan (Trodelvy) | Inhibitor | approved | mAb | DNA topoisomerase I inhibitor |
| st1481 | Inhibitor | experimental | Small molecule | DNA topoisomerase I inhibitor |
| tenifatecan | Inhibitor | experimental | Small molecule | TOP1 inhibitor |
| tlc-388 | Inhibitor | experimental | Small molecule | DNA topoisomerase I inhibitor |
| topotecan (hycamtin) | Inhibitor | approved | Small molecule | DNA topoisomerase I inhibitor |