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aclarubicin

Small moleculeexperimental

Aclarubicin (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer in China. It was previously approved for use in Europe but was discontinued in 2004 due to being rarely prescribed and unprofitable. — Wikipedia

Clinical trial activity

20 trials · 30 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
13
Phase 3
7
Phase 4
1

Earliest trial started Nov 1, 2012 (NCT01690507)

Timeline

2010s

  1. Jan 1, 2012

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2016

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2019

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC
Mol. weight
811.88 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • aclacinomycin
  • aclacinomycin a
  • aclacinomycin a
  • aclacinomycin a
  • aclacinomycin a
  • aclacinomycin hydrochloride
  • aclacinomycin s
  • aclacinomycin t
  • aclacinomycin x
  • aclacinomycin y
  • aclarubicin
  • aclarubicin
  • aclarubicin
  • aclarubicin
  • aclarubicin
  • aclarubicin
  • aclarubicin hcl
  • aclarubicin hcl
  • aclarubicin hcl

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06394011Phase 2Feb 15, 2024Soochow University
NCT05805072N/AMay 1, 2023Soochow University
NCT05918198Phase 2Feb 1, 2023Peking University
NCT05726110Phase 3Jan 29, 2023Antengene Corporation, Shanxi Bethune Hospital
NCT05662956Phase 1/Phase 2 (Phase 2)Dec 1, 2022People's Liberation Army of China
NCT05659992Phase 1Jan 10, 2022People's Liberation Army of China
NCT05264883Phase 3Mar 1, 2021Huai'an First People's Hospital, Nanjing Medical University, Nanjing University, Yancheng First People's Hospital
NCT04254640Phase 2Jun 1, 2020Sun Yat-Sen University
NCT04216355Phase 2/Phase 3 (Phase 3)Jan 31, 2020Fujian Medical University
NCT04087967Phase 3Apr 1, 2019Changzhou No.2 People's Hospital, Huai'an Second People's Hospital, Jingjiang People's Hospital, Kunming Medical University, Soochow University, The First People's Hospital of Lianyungang, Zhangjiagang First People's Hospital
NCT04083911Phase 3Apr 1, 2019Changzhou No.2 People's Hospital, Jingjiang People's Hospital, Kunming Medical University, Soochow University, The First People's Hospital of Lianyungang, The Second People's Hospital of Huai'an, Zhangjiagang First People's Hospital
NCT04446130Phase 3Jan 1, 2019Anhui Medical University, Changzhou No.2 People's Hospital, Henan Medical University, Nanjing University, Shandong Provincial Hospital, Shenzhen University, Soochow University, The Second People's Hospital of Huai'an
NCT03045627Phase 2Jan 1, 2017Shandong University
NCT03181815Phase 2Jan 1, 2017Sun Yat-Sen University
NCT03026842Phase 4Jan 1, 2017Dalian Medical University, Jilin University
NCT02723448Phase 1Dec 1, 2016Washington University in St. Louis
NCT02850822Phase 2/Phase 3 (Phase 3)Jul 1, 2016Guangzhou Medical University, Southern Medical University, Sun Yat-Sen University
NCT02886559Phase 1/Phase 2 (Phase 2)Jun 1, 2016Government of China, People's Liberation Army of China
NCT02432911N/AApr 1, 2015Chinese Academy of Medical Sciences
NCT01690507Phase 1/Phase 2 (Phase 2)Nov 1, 2012Government of China, People's Liberation Army of China
Showing 20 of 20 trials
Page 1 / 1

Organizations

Research & Development (30)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Soochow UniversityAcademic/Hospital5532019
People's Liberation Army of ChinaGovernment4422012
Changzhou No.2 People's HospitalAcademic/Hospital3012019
Sun Yat-Sen UniversityAcademic/Hospital3222016
Government of ChinaGovernment2012012
Jingjiang People's HospitalAcademic/Hospital2012019
Kunming Medical UniversityAcademic/Hospital2012019
Nanjing UniversityAcademic/Hospital2012019
The First People's Hospital of LianyungangAcademic/Hospital2012019
The Second People's Hospital of Huai'anAcademic/Hospital2012019
Zhangjiagang First People's HospitalAcademic/Hospital2012019
Anhui Medical UniversityAcademic/Hospital1012019
Antengene CorporationFor profit1012023
Chinese Academy of Medical SciencesAcademic/Hospital1112015
Dalian Medical UniversityAcademic/Hospital1012017
Fujian Medical UniversityAcademic/Hospital1112020
Guangzhou Medical UniversityAcademic/Hospital1012016
Henan Medical UniversityAcademic/Hospital1012019
Huai'an First People's HospitalAcademic/Hospital1012021
Huai'an Second People's HospitalAcademic/Hospital1012019
30 organizations
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