becatecarin
Small moleculeexperimental
Clinical trial activity
13 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
10
Phase 3
1
Phase 4
0
Earliest trial started Jan 1, 1999 (NCT00003737)
Timeline
Indications
Studied for
- Anemia, Refractory · Phase 1
- Bile Duct Neoplasms · Phase 2
- Biliary Tract Neoplasms · Phase 3
- Brain Neoplasms · Phase 2
- Breast Neoplasms · Phase 2
- Breast Neoplasms, Male · Phase 2
- Colorectal Neoplasms · Phase 2
- Gallbladder Neoplasms · Phase 2
- Intestinal Neoplasms · Phase 1
- Kidney Neoplasms · Phase 2
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Leukemia, Myeloid, Acute · Phase 1
- Leukemia, Myeloid, Chronic-Phase · Phase 1
- Leukemia, Myelomonocytic, Chronic · Phase 1
- Liver Neoplasms · Phase 2
- Lung Neoplasms · Phase 2
- Lymphoma · Phase 2
- Myelodysplastic Syndromes · Phase 1
- Neoplasms · Phase 2
- Neuroblastoma · Phase 2
- Ovarian Neoplasms · Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
- Retinoblastoma · Phase 2
- Sarcoma · Phase 2
- Small Cell Lung Carcinoma · Phase 2
Mechanism of action
- DNA topoisomerase IINHIBITOR
TOP1 inhibitor
- DNA topoisomerase IIINHIBITOR
DNA topoisomerase II inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCN(CC)CCN1C(=O)c2c(c3c4cccc(Cl)c4n([C@@H]4O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]4O)c3c3[nH]c4c(Cl)cccc4c23)C1=O- Mol. weight
- 669.56 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2107313 ↗
Also known as
- becatecarin
- becatecarin
- becatecarin
- becatecarin
- becatecarin hydrochloride
- becatecarin tartrate
- bm-27557-14
- bms 181176
- bms-181176
- bms-181176
- bms-181176
- bms 181176-1
- bms-181176-1
- bms 181176-14
- bms-181176-14
- bmy 27557
- bmy-27557
- bmy-27557
- bmy-27557
- bmy 27557-1
- bmy-27557-1
- bmy 27557-14
- deae-rbm
- diethylaminoethyl-rebeccamycin
- nsc 655649
- nsc-655649
- nsc d640199
- nsc-d640199
- rebeccamycin, diethylaminoethyl-
- xl 119
- xl-119
- xl-119
- xl-119
- xl119 compound
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00090025 | Phase 3 | Sep 1, 2004 | Case Western Reserve University, Helsinn |
| NCT00087204 | Phase 1 | May 1, 2004 | National Cancer Institute (NCI), University of Texas at Houston |
| NCT00086983 | Phase 1 | May 1, 2004 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00084487 | Phase 2 | Apr 1, 2004 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00006102 | Phase 2 | Jul 1, 2000 | National Cancer Institute (NCI), University of Texas, San Antonio |
| NCT00006262 | Phase 2 | Jul 1, 2000 | National Cancer Institute (NCI), Northwestern University |
| NCT00005027 | Phase 2 | Jun 1, 2000 | National Cancer Institute (NCI), Wayne State University |
| NCT00006017 | Phase 2 | May 1, 2000 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00005817 | Phase 2 | Mar 1, 2000 | Harvard University, National Cancer Institute (NCI) |
| NCT00005085 | Phase 2 | Feb 1, 2000 | National Cancer Institute (NCI), Yeshiva University |
| NCT00004189 | Phase 1 | Oct 1, 1999 | National Cancer Institute (NCI), University of Texas, San Antonio |
| NCT00005997 | Phase 2 | Apr 1, 1999 | Case Western Reserve University, National Cancer Institute (NCI) |
| NCT00003737 | Phase 2 | Jan 1, 1999 | Cornell University, National Cancer Institute (NCI) |
Showing 13 of 13 trials
Page 1 / 1
Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 12 | 7 | 2 | 1999 |
| Case Western Reserve University | Academic/Hospital | 5 | 2 | 3 | 1999 |
| University of Texas, San Antonio | Academic/Hospital | 2 | 0 | 2 | 1999 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 1999 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2000 |
| Helsinn | For profit | 1 | 1 | 1 | 2004 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2000 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2004 |
| Wayne State University | Academic/Hospital | 1 | 1 | 1 | 2000 |
| Yeshiva University | Academic/Hospital | 1 | 0 | 1 | 2000 |
10 organizations
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