st1481
Small moleculeexperimental
Clinical trial activity
8 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2002 (NCT00033202)
Timeline
2000s
- Jan 1, 2002
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Topoisomerase IINHIBITOR
Topoisomerase I inhibitor
- DNA topoisomerase IINHIBITOR
DNA topoisomerase I inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2/C=N/OC(C)(C)C- Mol. weight
- 447.49 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL113051 ↗
Also known as
- 7-t-butoxyiminomethylcamptothecin
- 7-t-butoxyiminomethyl-camptothecin
- gimatecan
- gimatecan
- gimatecan
- gimatecan
- lbq707
- st1481
- st 1481
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00493571 | Phase 1 | Aug 1, 2007 | Novartis, University of Texas at Houston |
| NCT00487058 | Phase 1 | May 1, 2007 | Novartis |
| NCT00441610 | Phase 1 | Jan 1, 2007 | Novartis |
| NCT00410358 | Phase 1 | Jun 1, 2006 | Novartis |
| NCT00420485 | Phase 1 | Mar 1, 2006 | Novartis |
| NCT00087061 | Phase 1/Phase 2 (Phase 2) | May 1, 2004 | National Cancer Institute (NCI), University of California, Los Angeles |
| NCT00032903 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2002 | Leadiant Biosciences, Inc., Rhode Island Hospital |
| NCT00033202 | Phase 1 | Mar 1, 2002 | Harvard University, Leadiant Biosciences, Inc., Rhode Island Hospital |
Showing 8 of 8 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Novartis | For profit | 5 | 4 | 1 | 2006 |
| Leadiant Biosciences, Inc. | For profit | 2 | 2 | 2 | 2002 |
| Rhode Island Hospital | Academic/Hospital | 2 | 0 | 2 | 2002 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2002 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2004 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2004 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2007 |
7 organizations
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