← Mechanisms of action
CFTR
SINGLE PROTEINHomo sapiens
Preferred name: Cystic fibrosis transmembrane conductance regulator ChEMBL ↗
Linked proteins
Drugs acting on this target (50)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| ctp-656 | Activator | experimental | Small molecule | CFTR activator |
| deutivacaftor | Activator | approved | Small molecule | Cystic fibrosis transmembrane conductance regulator activator |
| elexacaftor (Trifakta) | Activator | approved | Small molecule | CFTR activator |
| fdl169 | Activator | experimental | Small molecule | CFTR activator |
| fdl176 | Activator | experimental | Small molecule | CFTR activator |
| glpg1837 | Activator | experimental | Small molecule | CFTR activator |
| glpg2451 | Activator | experimental | Small molecule | CFTR activator |
| Nesolicaftor | Activator | experimental | Small molecule | CFTR activator |
| pti-808 | Activator | experimental | Small molecule | CFTR activator |
| qbw251 | Activator | experimental | Small molecule | CFTR activator |
| vsj-110 | Activator | experimental | Small molecule | CFTR activator |
| vx-152 | Activator | experimental | Small molecule | CFTR activator |
| spl84 | Antisense inhibitor | experimental | Nucleic acid | CFTR antisense inhibitor |
| crofelemer (mytesi) | Inhibitor | approved | Small molecule | CFTR inhibitor |
| Galicaftor | Inhibitor | experimental | Small molecule | CFTR inhibitor |
| glpg2737 | Inhibitor | experimental | Small molecule | CFTR inhibitor |
| iowh-032 | Inhibitor | experimental | Small molecule | Cystic fibrosis transmembrane conductance regulator inhibitor |
| iowh032 | Inhibitor | experimental | Small molecule | CFTR inhibitor |
| Navocaftor | Inhibitor | experimental | Small molecule | CFTR inhibitor |
| qr-010 | Inhibitor | experimental | Nucleic acid | CFTR inhibitor |
| vx-272 | Inhibitor | experimental | Small molecule | CFTR inhibitor |
| bmd003 | Modulator | experimental | Small molecule | CFTR modulator |
| deutivacaftor | Modulator | approved | Small molecule | CFTR modulator |
| glpg3067 | Modulator | experimental | Small molecule | CFTR modulator |
| Posenacaftor | Modulator | experimental | Small molecule | CFTR modulator |
| sion-109 | Modulator | experimental | Small molecule | CFTR modulator |
| sion-451 | Modulator | experimental | Small molecule | CFTR modulator |
| vanzacaftor (Alyftrek) | Modulator | approved | Small molecule | CFTR modulator |
| vx-440 | Modulator | experimental | Small molecule | CFTR modulator |
| vx-659 | Modulator | experimental | Small molecule | CFTR modulator |
| elexacaftor (Trifakta) | Positive modulator | approved | Small molecule | Cystic fibrosis transmembrane conductance regulator positive modulator |
| Galicaftor | Positive modulator | experimental | Small molecule | Cystic fibrosis transmembrane conductance regulator positive modulator |
| ivacaftor (Kalydeco) | Positive modulator | approved | Small molecule | CFTR positive modulator |
| tezacaftor (Trifakta) | Positive modulator | approved | Small molecule | CFTR positive modulator |
| vanzacaftor (Alyftrek) | Positive modulator | approved | Small molecule | Cystic fibrosis transmembrane conductance regulator positive modulator |
| lumacaftor (Orkambi) | Stabiliser | approved | Small molecule | CFTR stabiliser |
| 4d-710 | Supplementation | experimental | Gene therapy | CFTR supplementation |
| ad5-cb-cftr | Supplementation | experimental | Gene therapy | CFTR supplementation |
| adeno-associated virus-cftr vector | Supplementation | experimental | Gene therapy | CFTR supplementation |
| arct-032 | Supplementation | experimental | Gene therapy | CFTR supplementation |
| bi 3720931 | Supplementation | experimental | Gene therapy | CFTR supplementation |
| cystic fibrosis transmembrane conductance regulator | Supplementation | experimental | Gene therapy | CFTR supplementation |
| elx-02 | Supplementation | experimental | Small molecule | CFTR supplementation |
| h5.001cbcftr | Supplementation | experimental | Gene therapy | CFTR supplementation |
| kb407 | Supplementation | experimental | Gene therapy | CFTR supplementation |
| mrt5005 | Supplementation | experimental | Gene therapy | CFTR supplementation |
| pgm169/gl67a | Supplementation | experimental | Gene therapy | CFTR supplementation |
| rct2100 | Supplementation | experimental | Nucleic acid | CFTR supplementation |
| tgaavcf | Supplementation | experimental | Gene therapy | CFTR supplementation |
| vx-522 | Supplementation | experimental | Nucleic acid | CFTR supplementation |